type I DNA topoisomerase

出典: meddic


DNA topoisomeraseDNA topoisomerase Itopoisomerase I

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/26 05:30:45」(JST)

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  • p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells.
  • Montariello D, Troiano A, Malanga M, Calabrò V, Quesada P.SourceDepartment of Biology, University of Naples Federico II, Italy.
  • Biochemical pharmacology.Biochem Pharmacol.2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
  • Poly(ADP-ribose)polymerase 1 (PARP-1) inhibitors are thought as breakthrough for cancer treatment in solid tumors such as breast cancer through their effects on PARP's enzymatic activity. Our previous findings showed that the hydrophilic PARP inhibitor PJ34 enhances the sensitivity of p53 proficient
  • PMID 23376119
  • Topoisomerase 1-mediated removal of ribonucleotides from nascent leading-strand DNA.
  • Williams JS, Smith DJ, Marjavaara L, Lujan SA, Chabes A, Kunkel TA.SourceLaboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.
  • Molecular cell.Mol Cell.2013 Mar 7;49(5):1010-5. doi: 10.1016/j.molcel.2012.12.021. Epub 2013 Jan 31.
  • RNase H2-dependent ribonucleotide excision repair (RER) removes ribonucleotides incorporated during DNA replication. When RER is defective, ribonucleotides in the nascent leading strand of the yeast genome are associated with replication stress and genome instability. Here, we provide evidence that
  • PMID 23375499
  • Transcription-dependent dynamic supercoiling is a short-range genomic force.
  • Kouzine F, Gupta A, Baranello L, Wojtowicz D, Ben-Aissa K, Liu J, Przytycka TM, Levens D.SourceLaboratory of Pathology, National Cancer Institute, Bethesda, Maryland, USA.
  • Nature structural & molecular biology.Nat Struct Mol Biol.2013 Mar;20(3):396-403. doi: 10.1038/nsmb.2517. Epub 2013 Feb 17.
  • Transcription has the capacity to mechanically modify DNA topology, DNA structure and nucleosome arrangement. Resulting from ongoing transcription, these modifications in turn may provide instant feedback to the transcription machinery. To substantiate the connection between transcription and DNA dy
  • PMID 23416947


  • Nuclear dynamics of topoisomerase II beta reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain
  • An Easy-to-use Genotoxicity Assay Using EGFP-MDC1-expressing Human Cells
  • 全身性強皮症における自己抗体とその臨床的特徴
  • 日本臨床免疫学会会誌 = Japanese journal of clinical immunology 36(3), 139-147, 2013-06-30
  • NAID 10031185520


I. Introduction DNA topoisomerases are a class of enzymes involved in the regulation of DNA supercoiling. Type I topoisomerases change the degree of supercoiling of DNA by causing single-strand breaks and re-ligation, whereas type II ...
In order to perform unraveling of a "compensating winding up" DNA, enzymes are required (1). Topoisomerase changes the linking number as well as catalyzes the interconversionn of other kinds of topological isomers of DNA (2). ...


Type IA topoisomerases [edit]Dna Topoisomerases Type Ii DNA gyrase homologous to all other type points for type II topoisomerasesDna Topoisomerase manage and exploit topoisomerase function

リンク元DNAトポイソメラーゼI」「I型DNAトポイソメラーゼ」「topoisomerase I」「DNA topoisomerase」「DNA topoisomerase I
拡張検索eukaryotic type I DNA topoisomerase」「archaeal type I DNA topoisomerase」「bacterial type I DNA topoisomerase



DNA topoisomerase Itype I DNA topoisomerase



type I DNA topoisomerase

topoisomerase I」



DNA topoisomeraseDNA topoisomerase Itype I DNA topoisomerase

DNA topoisomerase」

  [★] DNAトポイソメラーゼ

DNA topoisomerase Itopoisomerase Itype I DNA topoisomerase

DNA topoisomerase I」



DNA topoisomerasetopoisomerase Itype I DNA topoisomerase

eukaryotic type I DNA topoisomerase」


  • 真核生物ト・イソメラーゼI
eukaryotic topoisomerase I

archaeal type I DNA topoisomerase」


  • 古細菌DNAト・イソメラーゼI

bacterial type I DNA topoisomerase」


  • 細菌DNAト・イソメラーゼI



  • n.
(windows)ファイル内容表示(linux -> cat])
ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
formmodepatterntype specimentyped

WordNet   license wordnet

「write by means of a keyboard with types; "type the acceptance letter, please"」

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「a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"」

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「(biology) the taxonomic group whose characteristics are used to define the next higher taxon」

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「a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"」

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「all of the tokens of the same symbol; "the word `element'' contains five different types of character"」

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「printed characters; "small type is hard to read"」

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「identify as belonging to a certain type; "Such people can practically be typed"」

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「〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ」



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「the 9th letter of the Roman alphabet」

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「the 4th letter of the Roman alphabet」

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deoxyribonucleic acid
リボ核酸 RNA

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「deoxyribonucleic acidディオキシリボ核酸」



  • n.
  • タイプで打つこと、タイピング。分類

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「writing done with a typewriter」