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トランスサイレチン TTR

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/01/12 02:06:07」(JST)

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  • An insight to the conserved water mediated dynamics of catalytic His88 and its recognition to thyroxin and RBP binding residues in human transthyretin.
  • Banerjee A1, Mukhopadhyay BP.
  • Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2015 Sep;33(9):1973-88. doi: 10.1080/07391102.2014.984632. Epub 2014 Dec 8.
  • Human transthyretin (hTTR) is a multifunctional protein involved in several amyloidogenic diseases. Besides transportation of thyroxin and vitamin-A, its role towards the catalysis of apolipoprotein-A1 and Aβ-peptide are also drawing interest. The role of water molecules in the catalytic mechanism
  • PMID 25372987
  • Distinctive Patterns of Transthyretin Amyloid in Salivary Tissue: A Clinicopathologic Study of 92 Patients With Amyloid-containing Minor Salivary Gland Biopsies.
  • Jamet MP1, Gnemmi V, Hachulla É, Dhaenens CM, Bouchindhomme B, Delattre C, Glowacki F, Hatron PY, Lacour A, Lamblin N, Launay D, Leleu X, Guiochon-Mantel A, Valleix S, Maurage CA, Copin MC, Buob D.
  • The American journal of surgical pathology.Am J Surg Pathol.2015 Aug;39(8):1035-44. doi: 10.1097/PAS.0000000000000430.
  • Accurate typing of amyloidosis is still a major issue for pathologists and clinicians. Besides clinical data and immunohistochemistry, the histologic distribution of amyloid could represent a useful tool to prevent typing errors, such as the misdiagnosis of hereditary and senile amyloidosis as light
  • PMID 25828388
  • Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates.
  • Chao CC1, Huang CM2, Chiang HH2, Luo KR2, Kan HW2, Yang NC2, Chiang H2, Lin WM2, Lai SM2, Lee MJ1, Shun CT3,4, Hsieh ST1,2,5,6.
  • Annals of neurology.Ann Neurol.2015 Aug;78(2):272-83. doi: 10.1002/ana.24438. Epub 2015 Jul 1.
  • OBJECTIVE: Autonomic neuropathy is a major component of familial amyloid polyneuropathy (FAP) due to mutated transthyretin, with sudomotor failure as a common manifestation. This study aimed to investigate the pathology and clinical significance of sudomotor denervation.METHODS: Skin biopsies were p
  • PMID 25973863


  • Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy – Comparative Strain Imaging Study –
  • ヒト変性椎間板に関するプロテオーム解析
  • Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy – Comparative Strain Imaging Study –


Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol binding protein bound to retinol. This is how transthyretin gained its name, transports thyroxine and retinol. The liver secretes ...
由来, E.coli expressed human transthyretin, E.coli expressed human transthyretin variant (V30M), E.coli expressed human transthyretin variant (L55P). 外観, 凍結 乾燥品. 保存バッファー, 20 mmol/l 重炭酸アンモニウム. 備考, 6×ヒスチジンタグ付き ...



拡張検索transthyretin gene mutation」「transthyretin mutant」「transthyretin variant



transthyretin, TTR
プレアルブミン, prealbuminthyroxine-binding prealbumin TBPA
  • 蛋白分画でAlb分画に分けられる
  • トランスサイレチンの分解産物はangiostatic factorのvasculostatinと呼ばれる






  • transthyretinの分解産物


  [★] トランスサイレチン transthyretin

transthyretin gene mutation」

  [★] トランスサイレチン遺伝子異常

transthyretin mutant」

  [★] トランスサイレチン変異体

transthyretin variant」

  [★] トランスサイレチン変異体