WordNet

tending to undergo or resulting from mutation; "a mutant gene"
an animal that has undergone mutation
(biology) an organism that has characteristics resulting from chromosomal alteration (同)mutation, variation, sport

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Current indications, strategies, and outcomes with cardiac transplantation for cardiac amyloidosis and sarcoidosis.

Rosenbaum AN1, Edwards BS.
Current opinion in organ transplantation.Curr Opin Organ Transplant.2015 Oct;20(5):584-92. doi: 10.1097/MOT.0000000000000229.
PURPOSE OF REVIEW: We describe the general strategies for the management of cardiac amyloidosis with particular focus on the use of cardiac transplantation for amyloid cardiomyopathy. Within this article, we highlight recent data regarding the use of combined heart transplant-chemotherapy, use of ca
PMID 26262459

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study.

Suhr OB1, Coelho T2, Buades J3, Pouget J4, Conceicao I5, Berk J6, Schmidt H7, Waddington-Cruz M8, Campistol JM9, Bettencourt BR10, Vaishnaw A11, Gollob J12, Adams D13.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2015 Sep 4;10:109. doi: 10.1186/s13023-015-0326-6.
BACKGROUND: Transthyretin-mediated amyloidosis is an inherited, progressively debilitating disease caused by mutations in the transthyretin gene. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of patisiran (ALN-TTR02), a small interfering RNA
PMID 26338094

Atrial fibrillation in amyloidotic cardiomyopathy: prevalence, incidence, risk factors and prognostic role.

Longhi S1, Quarta CC, Milandri A, Lorenzini M, Gagliardi C, Manuzzi L, Bacchi-Reggiani ML, Leone O, Ferlini A, Russo A, Gallelli I, Rapezzi C.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.Amyloid.2015 Sep;22(3):147-55. doi: 10.3109/13506129.2015.1028616. Epub 2015 Jun 5.
BACKGROUND: Although atrial fibrillation (AF) is a known complication of amyloidotic cardiomyopathy (AC), a precise pathophysiological and prognostic characterization is not available. We therefore aimed to assess prevalence, incidence, risk factors and prognostic significance of AF in light-chain (
PMID 25997105

An Isolated Case of Late-onset Amyloidogenic Transthyretin Type Familial Amyloid Polyneuropathy Associated with a Mutant Transthyretin Substituting Methionine for Valine at Position 30 Showing Latent Progressive Cardiac Involvement Confirmed by Serial Annual Electrocardiograms