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street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

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酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/05 12:39:33」(JST)

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Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals, which includes all higher animals from fish to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo.^[2] It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.^[3]

The key role of retinoic acid in embryonic development mediates the high teratogenicity of retinoid pharmaceuticals, such as isotretinoin used for treatment of cancer and acne. Oral megadoses of pre-formed vitamin A (retinyl palmitate), and retinoic acid itself, also have teratogenic potential by this same mechanism.

Mechanism of biological action

Retinoic acid acts by binding to the retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR) in regions called retinoic acid response elements (RAREs). Binding of the retinoic acid ligand to RAR alters the conformation of the RAR, which affects the binding of other proteins that either induce or repress transcription of a nearby gene (including Hox genes and several other target genes). Retinoic acid receptors mediate transcription of different sets of genes controlling differentiation of a variety of cell types, thus the target genes regulated depend upon the target cells.^[4] In some cells, one of the target genes is the gene for the retinoic acid receptor itself (RAR-beta in mammals), which amplifies the response.^[5] Control of retinoic acid levels is maintained by a suite of proteins that control synthesis and degradation of retinoic acid.^[2]^[3]

The molecular basis for the interaction between retinoic acid and the Hox genes has been studied by using deletion analysis in transgenic mice carrying constructs of lacZ reporter genes. Such studies have identified functional RAREs within flanking sequences of some of the most 3' Hox genes (including Hoxa1, Hoxb1, Hoxb4, Hoxd4), suggesting a direct interaction between the genes and retinoic acid. These types of studies strongly support the normal roles of retinoids in patterning vertebrate embryogenesis through the Hox genes.^[6]

Biosynthesis

Retinoic acid can be produced in the body by two sequential oxidation steps that convert retinol to retinaldehyde to retinoic acid, but once produced it cannot be reduced again to retinol. The enzymes that generate retinoic acid for control of gene expression include retinol dehydrogenases (i.e. Rdh10) that metabolize retinol to retinaldehyde, and retinaldehyde dehydrogenases: RALHD1 (ALDH1A1), RALHD2 (ALDH1A2), and RALHD3 (ALDH1A3)^[7] that metabolize retinaldehyde to retinoic acid.^[2] Enzymes that metabolize excess retinol to prevent toxicity include alcohol dehydrogenase and cytochrome P450(cyp26).

Retinoic acid function in the absence of precursors retinol or retinaldehyde

Retinoic acid is responsible for most of the activity of vitamin A, save visual pigment effects that require retinal (retinaldehyde), and cell metabolism effects that may require retinol itself. Also, some biochemical functions necessary for fertility in vitamin A deficient male and female mammals originally appeared to require retinol for rescue, but this is due to a requirement for local conversion of retinol to retinoic acid, as administered retinoic acid does not reach some critical tissues unless given in high amounts. Thus, if animals are fed only retinoic acid but no vitamin A (retinol or retinal), they suffer none of the growth-stunting or epithelial-damaging effects of lack of vitamin A (including no xerophthalmia—dryness of the cornea). They do suffer retina degeneration and blindness, due to retinal (retinaldehyde) deficiency.

In addition, vitamin A-deprived but retinoic acid-supplemented male rats exhibit hypogonadism and infertility due to lack of local retinoic acid synthesis in the testis; similar treatment of female rats causes infertility due to fetal resorption caused by a lack of local retinoic acid synthesis in the embryo.^[8]^[9] The retinoic acid synthesis in testes is catalyzed primarily by the RALDH2 (ALDH1A2) aldehyde dehydrogenase. Suppressing this enzyme has been proposed as a possible way to make a male contraceptive pill, because retionic acid is necessary for spermatogenesis in humans much like in rats.^[10]

Related pharmaceuticals

Tretinoin (Tradename: Retin-A)
Isotretinoin (Tradename: Accutane(US), Roaccutane)

References

^ ^a ^b Merck Index, 13th Edition, 8251.
^ ^a ^b ^c Duester, G (September 2008). "Retinoic Acid Synthesis and Signaling during Early Organogenesis". Cell 134 (6): 921–31. doi:10.1016/j.cell.2008.09.002. PMC 2632951. PMID 18805086.
^ ^a ^b Holland, Linda Z. (2007). "Developmental biology: A chordate with a difference". Nature 447 (7141): 153–155. doi:10.1038/447153a. PMID 17495912.
^ Venkatesh K, Srikanth L, Vengamma B, Chandrasekhar C, Sanjeevkumar A, Mouleshwara Prasad BC, Sarma PV. In vitro differentiation of cultured human CD34+ cells into astrocytes. Neurol India 2013;61:383-8
^ Edgar Wingender (1993). "Steroid/Thyroid Hormone Receptors". Gene Regulation in Eukaryotes. New York: VCH. p. 316. ISBN 1-56081-706-2.
^ Marshall, H.; et al. (1996). "Retinoids and Hox genes" (PDF). The FASEB Journal 10 (9): 969–978. Retrieved 2009-02-19.
^ "ALDH 1 Family". Dr. Vasilis Vasiliou's laboratory at the University of Colorado's Health Sciences Center. Retrieved 22 October 2012.
^ http://la.rsmjournals.com/cgi/content/abstract/5/2/239 Lab Anim 1971;5:239-250. The production of experimental vitamin A deficiency in rats and mice. T. Moore and P. D. Holmes. doi:10.1258/002367771781006492.
^ VanPelt, H.M.M.; DeRooij, D.G. (1991). "Spermatogenesis in retinol-deficient rats maintained on retinoic acid". Endocrinology 128 (2): 697–704. doi:10.1530/jrf.0.0940327. PMID 1593535.
^ Sam Kean (2012). "Reinventing the Pill: Male Birth Control". Science 338: 318–320. doi:10.1126/science.338.6105.318. PMID 23087225.

External links

Retinoic acid bound to proteins in the PDB

UpToDate Contents

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Combination of microneedling and 10% trichloroacetic acid peels in the management of infraorbital dark circles.

Kontochristopoulos G1, Kouris A1, Platsidaki E1, Markantoni V1, Gerodimou M1, Antoniou C1.
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BACKGROUND: Dark circles (DC), seen in the periorbital area, are defined as bilateral, round, homogeneous pigmented macules whose aetiology is thought to be multifactorial. Available treatments include bleaching creams, topical retinoic acid, chemical peels, lasers, autologous fat transplantation, i
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IL-33 enhances retinoic acid signaling on CD4+ T cells.

Gajardo T1, Pérez F2, Terraza C1, Campos-Mora M1, Noelle RJ3, Pino-Lagos K4.
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Several molecules have been described as CD4+ T cells differentiation modulators and among them retinoic acid (RA) and more recently, IL-33, have been studied. Due to the similarities in T helper cell skewing properties between RA and IL-33, we asked whether IL-33 intersects, directly or indirectly,
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ALDH1A3, a metabolic target for cancer diagnosis and therapy.

Duan JJ1, Cai J2, Guo YF1, Bian XW1, Yu SC1.
International journal of cancer.Int J Cancer.2016 Sep 1;139(5):965-75. doi: 10.1002/ijc.30091. Epub 2016 Apr 4.
Metabolism reprogramming has been linked with the initiation, metastasis, and recurrence of cancer. The aldehyde dehydrogenase (ALDH) family is the most important enzyme system for aldehyde metabolism. The human ALDH family is composed of 19 members. ALDH1A3 participates in various physiological pro
PMID 26991532

Japanese Journal

Eradication of Hepatitis C Virus Subgenomic Replicon by Interferon Results in Aberrant Retinol-Related Protein Expression

Koike Kazuko,Takaki Akinobu,Kato Nobuyuki,Ouchida Mamoru,Kanzaki Hirotaka,Yasunaka Tetsuya,Shiraha Hidenori,Miyake Yasuhiro,Yamamoto Kazuhide
Acta Medica Okayama 66(6), 461-468, 2012-12
… Replicon-harboring cells showed higher expression of retinal dehydrogenase 1 (RALDH-1), which converts retinol to retinoic acid, and the cured cells showed higher expression of retinol-binding protein (RBP), which transports retinol from the liver to target tissues. …
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APLにおけるATRA症候群および再発の危険因子としてのBMI高値

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Related Pictures

★リンクテーブル★

リンク元	「トレチノイン」「RA」「レチノイン酸」
拡張検索	「trans-retinoic acid」「cytoplasmic retinoic acid-binding protein」「9-cis-retinoic acid receptor」「all-trans-retinoic acid」

「トレチノイン」

All-trans-retinoic acid
Names
	IUPAC name (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
	Other names vitamin A acid; RA
Identifiers
CAS Number	302-79-4
ChEMBL	ChEMBL38
IUPHAR/BPS	2644
Jmol interactive 3D	Image
PubChem	444795
	SMILES CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C ;
Properties
Chemical formula	C20H28O2
Molar mass	300.43512 g/mol
Appearance	yellow to light orange crystalline powder with characteristic floral odor
Melting point	180 to 182 °C (356 to 360 °F; 453 to 455 K) crystals from ethanol
Solubility in water	nearly insoluble
Solubility in fat	soluble
Related compounds
Related compounds	retinol; retinal; beta-carotene
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references