関: replication protein C、RFC

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
(genetics) the process whereby DNA makes a copy of itself before cell division
the repetition of an experiment in order to test the validity of its conclusion; "scientists will not believe an experimental result until they have seen at least one replication"
(law) a pleading made by a plaintiff in reply to the defendants plea or answer

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
carbonの化学記号
写し,複写,複製 / 《文》(被告の訴答に対する)原告の訴答
cesiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/05 16:16:21」(JST)

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The replication factor C, or RFC, is a five-subunit^[1] protein complex that is required for DNA replication.

The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 (in S. cerevisiae). RFC is used in eukaryotic replication as a clamp loader, similar to the γ Complex in E. coli. Its role as clamp loader involves catalysing the loading of PCNA on to DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. ATP hydrolysis causes release of RFC, with concomitant clamp loading onto DNA.

References[edit]

^ Replication Protein C at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Abscisic Acid Suppresses the Highly Occurred Somatic Homologous Recombination in Arabidopsis rfc1 Mutant.

Yao T, Jin D, Liu Q, Gong Z.SourceState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Journal of genetics and genomics = Yi chuan xue bao.J Genet Genomics.2013 Sep 20;40(9):465-71. doi: 10.1016/j.jgg.2013.05.006. Epub 2013 Jun 10.
The phytohormone abscisic acid (ABA) regulates many aspects of plant growth, including seed germination, root growth and cell division. Previous study indicates that ABA treatment increases DNA damage and somatic homologous recombination (HR) in Arabidopsis abo4/pol ɛ (aba overly-sensitive 4 /DNA p
PMID 24053948

DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.

Lormand JD, Buncher N, Murphy CT, Kaur P, Lee MY, Burgers P, Wang H, Kunkel TA, Opresko PL.SourceDepartment of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 100 Technology Drive, Pittsburgh, PA 15219, USA, Department of Physics, North Carolina State University, 2401 Stinson Drive, Raleigh, NC, 27695, USA, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA and Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.
Nucleic acids research.Nucleic Acids Res.2013 Sep 13. [Epub ahead of print]
Previous evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA replication. The precise impediments to replication fork progression at telomeric TTAGGG repeats are unknown, but are proposed to include G-quadruplexes (G4) on the G-rich strand. Here we examine
PMID 24038470

Assembly and Distributive Action of an Archaeal DNA Polymerase Holoenzyme.

Bauer RJ, Wolff ID, Zuo X, Lin HK, Trakselis MA.SourceDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Journal of molecular biology.J Mol Biol.2013 Sep 11. pii: S0022-2836(13)00560-3. doi: 10.1016/j.jmb.2013.09.003. [Epub ahead of print]
The assembly and enzymatic ability of the replication DNA polymerase holoenzyme from Sulfolobus solfataricus (Sso) was investigated using presteady-state fluorescence resonance energy transfer assays coupled with functional and structural studies. Kinetic experiments reveal that ATP binding to repli
PMID 24035812

Japanese Journal

Uracil DNA Glycosylase Counteracts APOBEC3G-Induced Hypermutation of Hepatitis B Viral Genomes: Excision Repair of Covalently Closed Circular DNA

Kitamura Kouichi,Wang Zhe,Chowdhury Sajeda,Simadu Miyuki,Koura Miki,Muramatsu Masamichi
PLoS Pathogens 9(5), e1003361, 2013-05-00
… We investigated whether uracil residues in hepadnavirus DNA were excised by uracil-DNA glycosylase (UNG), a host factor for base excision repair (BER). … To assess the effect of UNG on the cccDNA viral intermediate, we used the duck HBV (DHBV) replication model. … UNG inhibition also enhanced the APOBEC3G-mediated suppression of viral replication, including reduction of NC-DNA, pre-C mRNA, and secreted viral particle-associated DNA in prolonged culture. …
NAID 120005304726

Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells

Hasei Joe,Sasaki Tsuyoshi,Tazawa Hiroshi,Osaki Shuhei,Yamakawa Yasuaki,Kunisada Toshiyuki,Yoshida Aki,Hashimoto Yuuri,Onishi Teppei,Uno Futoshi,Kagawa Shunsuke,Urata Yasuo,Ozaki Toshifumi,Fujiwara Toshiyoshi
Molecular Cancer Therapeutics 12(3), 314-325, 2013-03-00
… Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. … We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that kills human osteosarcoma cells, but some human osteosarcoma cells were OBP-301-resistant. …
NAID 120005324798

Development of Incurable Cancer Cell Targeted Agents Using Viral Technology

山村倫子,高橋克仁
YAKUGAKU ZASSHI 133(3), 297-303, 2013
… Since tumor cells present in a hypoxic environment are known to be resistant to chemotherapy and radiotherapy, we also engineered a novel oncolytic herpes virus targeting a specific tumor microenvironment, which harbors a gene encoding a fusion protein of oxygen-dependent degradation (ODD) domain of HIF1α and ICP4, a master viral transcription factor required for replication. …
NAID 130003361914