ラセマーゼ、ラセミ化酵素
- 関
- epimerase、racemase and epimerase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/16 19:14:32」(JST)
[Wiki en表示]
Epimerases and racemases are isomerase enzymes that catalyze the inversion of stereochemistry in biological molecules.[1] Racemases catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry. Epimerases catalyze the stereochemical inversion of the configuration about an asymmetric carbon atom in a substrate having more than one center of asymmetry, thus interconverting epimers.
Human epimerases include methylmalonyl-CoA epimerase, involved in the metabolic breakdown of the amino acids isoleucine, methionine and valine, and UDP-glucose 4-epimerase, which is used in the final step of galactose metabolism - catalyzing the reversible conversion of UDP-galactose to UDP-glucose.
References
- ^ Tanner, ME. (2002). "Understanding nature's strategies for enzyme-catalyzed racemization and epimerization". Acc. Chem. Res. 35 (4): 237–246. doi:10.1021/ar000056y. PMID 11955052.
External links
- http://medical-dictionary.thefreedictionary.com/racemase
- http://medical-dictionary.thefreedictionary.com/epimerase
- Entry Term Epimerases at the US National Library of Medicine Medical Subject Headings (MeSH)
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Isomerases: Epimerase and racemases (EC 5.1)
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| 5.1.1: Amino acids |
- Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
- Serine racemase
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| 5.1.2: Hydroxy acids |
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| 5.1.3: Carbohydrates |
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| 5.1.99: Other |
- Methylmalonyl CoA epimerase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Structural insights into the substrate recognition and reaction specificity of the PLP-dependent fold-type I isoleucine 2-epimerase from Lactobacillus buchneri.
- Awad R1, Gans P1, Reiser JB2.
- Biochimie.Biochimie.2017 Jun;137:165-173. doi: 10.1016/j.biochi.2017.03.015. Epub 2017 Mar 23.
- PMID 28344038
- Isolation and amino acid sequence of a dehydratase acting on d-erythro-3-hydroxyaspartate from Pseudomonas sp. N99, and its application in the production of optically active 3-hydroxyaspartate.
- Nagano H1, Shibano K1, Matsumoto Y1, Yokota A1, Wada M1.
- Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2017 Jun;81(6):1156-1164. doi: 10.1080/09168451.2017.1295804. Epub 2017 Mar 14.
- PMID 28290777
- Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.
- Duvall JR1, Bedard L2, Naylor-Olsen AM2, Manson AL1, Bittker JA1, Sun W3, Fitzgerald ME1, He Z3, Lee MD 4th1, Marie JC1, Muncipinto G1, Rush D2, Xu D3, Xu H3, Zhang M3, Earl AM1, Palmer MA1, Foley MA1, Vacca JP2, Scherer CA1.
- ACS infectious diseases.ACS Infect Dis.2017 May 12;3(5):349-359. doi: 10.1021/acsinfecdis.6b00206. Epub 2017 Mar 7.
- PMID 28215073
Japanese Journal
- D-アミノ酸関連酵素欠損に伴うほ乳類体内のD-アミノ酸含量変化 (特集 ビタミンB研究委員会平成25年度シンポジウム ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究 : ビタミン研究が切り拓く疾患生命科学のフロンティア)
- ビタミンB_6が担うD-セリンの代謝酵素 : セリンラセマーゼとD-セリンデヒドラターゼ(<特集>ビタミンB研究委員会平成25年度シンポジウム「ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究-ビタミン研究が切り拓く疾患生命科学のフロンティア」)
- 吉村 徹,伊藤 智和
- ビタミン 88(9), 462-468, 2014-09-25
- … In mammals, D-serine is synthesized from L-serine by a eukaryotic serine racemase (SR), a member of the fold-type II group of pyridoxal 5'-phosphate (PLP)-dependent enzymes. …
- NAID 110009844820
- ビタミンB₆が担うD-セリンの代謝酵素 : セリンラセマーゼとD-セリンデヒドラターゼ (特集 ビタミンB研究委員会平成25年度シンポジウム｢ビタミンB群が担う脳内アミノ酸代謝と疾患をターゲットにした次世代学術研究 : ビタミン研究が切り拓く疾患生命科学のフロンティア｣)
Related Links
- ALANINE RACEMASE (AlaR) [EC 5.1.1.1] from Bacillus stearothermophilus SPECIFICATION State: Lyophilized Specific activity: more than 950 U/mg protein Contaminants: (as AlaR activity = 100%) Lactate dehydrogenase : : ...
- racemase /ra·ce·mase/ (ra?sĕ-mās) an enzyme that catalyzes inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry. ra·ce·mase (rā′sə-mās′, -māz′, răs′ə-) n. An enzyme that catalyzes ...
★リンクテーブル★
[★]
- 英
- [[]]
- 同
- racemase
- 関
- [[]]
- 同
- racemase
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- 英
- racemase
- 関
- ラセマーゼ
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ラセマーゼとエピメラーゼ
- 関
- epimerase、racemase
[★]
メチルマロニルCoAラセマーゼ
[★]
アラニンラセマーゼ