nucleoside reverse transcriptase inhibitors

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spe- cific agents

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/08/29 16:33:39」(JST)

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英文文献

  • Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase.
  • Lee WG1, Frey KM2, Gallardo-Macias R1, Spasov KA2, Chan AH2, Anderson KS3, Jorgensen WL4.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Nov 1;25(21):4824-7. doi: 10.1016/j.bmcl.2015.06.074. Epub 2015 Jul 9.
  • Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that incorporate a 7-indolizinylamino or 2-naphthylamino substituent on a pyrimidine or 1,3,5-triazine core. The most potent compounds show below 10 nanomolar activity towards wild-type HIV-1 and variants bearing Tyr181Cy
  • PMID 26166629
  • Synthesis, Biological Evaluation and Molecular Modeling Studies of New 2,3-Diheteroaryl Thiazolidin-4-Ones as NNRTIs.
  • Debnath U1,2, Verma S1, Singh P3, Rawat K4, Gupta SK3, Tripathi RK4, Siddiqui HH2, Katti SB1, Prabhakar YS1.
  • Chemical biology & drug design.Chem Biol Drug Des.2015 Nov;86(5):1285-91. doi: 10.1111/cbdd.12591. Epub 2015 Jul 22.
  • In a focused exploration, thiazolidin-4-ones with different C-2 and N-3 substituent groups were synthesized and evaluated as non-nucleoside reverse transcriptase inhibitors against HIV-1. This has led to new active compounds sporting heteroaryls at both C-2 and N-3 positions prompting to view them i
  • PMID 26031778
  • Ligand similarity guided receptor selection enhances docking accuracy and recall for non-nucleoside HIV reverse transcriptase inhibitors.
  • Stanton RA1, Nettles JH1, Schinazi RF2,3.
  • Journal of molecular modeling.J Mol Model.2015 Nov;21(11):282. doi: 10.1007/s00894-015-2826-7. Epub 2015 Oct 8.
  • Non-nucleoside reverse transcriptase inhibitors (NNRTI) are allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), a viral polymerase essential to infection. Despite the availability of >150 NNRTI-bound RT crystal structures, rational design of new NNRTI
  • PMID 26450349

和文文献

  • Efficacy and safety of antiretroviral regimens including raltegravir to treat HIV-infected patients with hemophilia
  • Mass Spectrometric Characterization of HIV-1 Reverse Transcriptase Interactions with Non-nucleoside Reverse Transcriptase Inhibitors
  • Efficacy and safety of antiretroviral regimens including raltegravir to treat HIV-infected patients with hemophilia

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★リンクテーブル★
拡張検索nonnucleoside reverse transcriptase inhibitors
関連記事reverse」「inhibitor」「revers」「transcriptase」「nucleoside

nonnucleoside reverse transcriptase inhibitors」

  [★] 非核酸系逆転写酵素阻害薬


reverse」

  [★]

  • v.
  • 逆転させる、逆行する、逆戻りさせる、リバースする
  • adj.
  • 逆の、逆性の
adverselybackwardconverseconverselyinverseinverselyoppositeoppositelyretroreversal

WordNet   license wordnet

「of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"」

WordNet   license wordnet

「the gears by which the motion of a machine can be reversed」
reverse gear

WordNet   license wordnet

「the side of a coin or medal that does not bear the principal design」
verso

WordNet   license wordnet

「(American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction」

WordNet   license wordnet

「a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true"」
contrary, opposite

WordNet   license wordnet

「an unfortunate happening that hinders or impedes; something that is thwarting or frustrating」
reversal, setback, blow, black eye

PrepTutorEJDIC   license prepejdic

「(位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く」


inhibitor」

  [★]

  • n.
blockerdepressantsuppressant

WordNet   license wordnet

「a substance that retards or stops an activity」

PrepTutorEJDIC   license prepejdic

「抑制する人(物) / 化学反応抑制剤」


revers」

  [★]

WordNet   license wordnet

「a lapel on a woman''s garment; turned back to show the reverse side」
revere

PrepTutorEJDIC   license prepejdic

「(フランス語)(えりの)裏出し,折り返し」


transcriptase」

  [★]

DNA-dependent RNA polymeraseDNA-directed RNA polymeraseRNA polymerase

WordNet   license wordnet

「the enzyme that copies DNA into RNA」
RNA polymerase


nucleoside」

  [★]

ヌクレオシド

Nnucleosidic

WordNet   license wordnet

「a glycoside formed by partial hydrolysis of a nucleic acid」




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