medullary thyroid cancer

出典: meddic

甲状腺髄様癌

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/07 08:52:36」(JST)

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英文文献

  • RAS proto-oncogene in medullary thyroid carcinoma.
  • Moura MM1, Cavaco BM2, Leite V3.
  • Endocrine-related cancer.Endocr Relat Cancer.2015 Oct;22(5):R235-52. doi: 10.1530/ERC-15-0070.
  • Medullary thyroid carcinoma (MTC) is a rare malignancy originating from the calcitonin-secreting parafollicular thyroid C cells. Approximately 75% of cases are sporadic. Rearranged during transfection (RET) proto-oncogene plays a crucial role in MTC development. Besides RET, other oncogenes commonly
  • PMID 26285815
  • Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP.
  • Dodurga Y1, Eroğlu C, Seçme M, Elmas L, Avcı ÇB, Şatıroğlu-Tufan NL.
  • Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2015 Sep 3. [Epub ahead of print]
  • Ferulic acid (4-hydroxy-3-methoxycinnamic acid; FA), a common dietary plant phenolic compound, is abundant in fruits and vegetables. The aim of present study is to investigate the effects of FA on cell cycle, apoptosis, invasion, migration, and colony formation in the TT medullary thyroid cancer cel
  • PMID 26334619
  • PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma.
  • Petrulea MS1, Plantinga TS2, Smit JW2, Georgescu CE1, Netea-Maier RT3.
  • Cancer treatment reviews.Cancer Treat Rev.2015 Sep;41(8):707-13. doi: 10.1016/j.ctrv.2015.06.005. Epub 2015 Jun 26.
  • Thyroid carcinoma (TC) is the most common endocrine malignancy. The pathogenesis of TC is complex and involves multiple genetic events that lead to activation of oncogenic pathways such as the MAP kinase (MAPK) pathway and the PI3K/Akt/mTOR pathway. The PI3K/Akt pathway has emerged as an important p
  • PMID 26138515

和文文献

  • 縮小を認めた乳腺髄様癌の超音波および病理学的検討 (JABTS 33/パネルディスカッション 経過観察中に縮小した乳癌,その原因は? 組織型は?)
  • 乳腺甲状腺超音波医学 = Journal of breast and thyroid
  • NAID 40020552944
  • A novel RET gene mutation in a patient with apparently sporadic pheochromocytoma
  • 再発にて判明した遺伝性甲状腺髄様癌 (MEN2A/FMTC) の1例

関連リンク

Medullary thyroid cancer (MTC) is a form of thyroid carcinoma which originates from the parafollicular cells (C cells), which produce the hormone calcitonin. Medullary tumors are the third most common of all thyroid cancers. They make up ...
27 Feb 2012 ... Article discusses medullary thyroid cancer basics. Learn about common medullary thyroid cancer symptoms and treatments, such as thyroidectomy.

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★リンクテーブル★
先読み甲状腺髄様癌
リンク元髄様甲状腺癌
拡張検索hereditary medullary thyroid cancer
関連記事Cancer」「cancer」「medullary」「thyroid」「medulla

甲状腺髄様癌」

  [★]

medullary thyroid carcinoma MTCmedullary carcinoma of thyroid, thyroid medullary carcinoma
甲状腺C細胞癌thyroid C-cell carcinoma
アミロイドーシス甲状腺腫瘍甲状腺癌


概念

疫学

  • 甲状腺悪性腫瘍の5~10%? 甲状腺癌の1-2%(YN.D-41)
  • 男女比はほぼ1:1  男女比=1:2(YN.D-41) 
  • 発症年齢は30歳代と50歳代がピーク

病型

  • 家族性
  • 散発性

病因

  • RET遺伝子の点突然変異
  • 常染色体優性遺伝疾患の多発性内分泌腫瘍症2A型,同2B型とおなじ

病理

  • 腫瘍細胞の多様な像
  • 類円形から多角形のさまざまな形態をとる腫瘍細胞が、シート状、胞巣状、島状あるいは管状、濾胞状、乳頭状の構造を呈する
  • 間質のアミロイド沈着

病態

進展様式

  • リンパ行性が多く、血行性もある。

症状

  • 甲状腺腫脹

検査

  • 血液生化学
  • シンチグラム
  • 131I-MIBGによるシンチ:腫瘍に集積

合併症

予後

  • 10年生存率:60%

参考

  • 1. [charged] Clinical manifestations and staging of medullary thyroid cancer - uptodate [1]
  • 2. [charged] Treatment of medullary thyroid cancer - uptodate [2]
  • 3. [charged] Chemotherapy and immunotherapy for medullary thyroid cancer - uptodate [3]


髄様甲状腺癌」

  [★]

medullary thyroid carcinomamedullary thyroid cancer
甲状腺髄様癌


hereditary medullary thyroid cancer」

  [★] 遺伝型甲状腺髄様癌

Cancer」

  [★]

WordNet   license wordnet

「type genus of the family Cancridae」
genus Cancer

WordNet   license wordnet

「the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22」
Cancer the Crab, Crab

WordNet   license wordnet

「(astrology) a person who is born while the sun is in Cancer」
Crab

WordNet   license wordnet

「a small zodiacal constellation in the northern hemisphere; between Leo and Gemini」


cancer」

  [★]

癌腫
tumor


WordNet   license wordnet

「any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream」
malignant neoplastic disease

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉『がん』 / 〈U〉〈C〉害悪 / 《Cancer》(星座の)カニ座」


medullary」

  [★]

  • adj.
  • 延髄の、延髄性の、髄質の、髄質性の
bulbarmedullamedulla oblongata

WordNet   license wordnet

「of or relating to the medulla of any body part」

WordNet   license wordnet

「containing or consisting of or resembling bone marrow」

WordNet   license wordnet

「of or relating to the medulla oblongata」


thyroid」

  [★]

  • n.
thyroid glandthyroidal

WordNet   license wordnet

「suggestive of a thyroid disorder; "thyroid personality"」

WordNet   license wordnet

「of or relating to the thyroid gland; "thyroid deficiency"; "thyroidal uptake"」
thyroidal

PrepTutorEJDIC   license prepejdic

「甲状腺 / 甲状腺の」


medulla」

  [★]

副腎

  • 髄質

脳神経


WordNet   license wordnet

「the inner part of an organ or structure in plant or animal」

PrepTutorEJDIC   license prepejdic

「〈U〉骨髄 / =medulla oblongata」




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