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「an abnormal accumulation of bile pigment in the brain and other nerve tissue; causes yellow staining and tissue damage」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/31 08:54:44」(JST)

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  • Maternal knowledge and care-seeking behaviors for newborn jaundice in Sagamu, Southwest Nigeria.
  • Ogunlesi TA1, Abdul AR.
  • Nigerian journal of clinical practice.Niger J Clin Pract.2015 Jan-Feb;18(1):33-40. doi: 10.4103/1119-3077.146976.
  • BACKGROUND: Delay in the presentation of infants with jaundice at the hospital is a reason for the persistence of the severe forms of jaundice.OBJECTIVE: The aim was to determine the influence of maternal knowledge on newborn jaundice on their care-seeking practices.METHODS: In a cross-sectional sur
  • PMID 25511341
  • Movement disorders due to bilirubin toxicity.
  • Rose J1, Vassar R2.
  • Seminars in fetal & neonatal medicine.Semin Fetal Neonatal Med.2014 Dec 16. pii: S1744-165X(14)00087-0. doi: 10.1016/j.siny.2014.11.002. [Epub ahead of print]
  • Advances in the care of neonatal hyperbilirubinemia have led to a decreased incidence of kernicterus. However, neonatal exposure to high levels of bilirubin continues to cause severe motor symptoms and cerebral palsy (CP). Exposure to moderate levels of unconjugated bilirubin may also cause damage t
  • PMID 25524299
  • Why is kernicterus still a major cause of death and disability in low-income and middle-income countries?
  • Olusanya BO1, Ogunlesi TA2, Slusher TM3.
  • Archives of disease in childhood.Arch Dis Child.2014 Dec;99(12):1117-21. doi: 10.1136/archdischild-2013-305506. Epub 2014 Aug 14.
  • Neonatal jaundice is predominantly a benign condition that affects 60%-80% of newborns worldwide but progresses to potentially harmful severe hyperbilirubinaemia in some. Despite the proven therapeutic benefits of phototherapy for preventing extreme hyperbilirubinaemia, acute bilirubin encephalopath
  • PMID 25123403


  • The significance of measurement of serum unbound bilirubin concentrations in high-risk infants
  • LEE Yong-Kye,DAITO Yasuyo,KATAYAMA Yoshinori,MINAMI Hirotaka,NEGISHI Hirokuni
  • Pediatrics international : official journal of the Japan Pediatric Society 51(6), 795-799, 2009-12-01
  • NAID 10028180512
  • 新生児期に高度の高ビリルビン血症を認めず乳児期にアテトーゼ様の神経症状を呈した早産児の3例
  • 神農 英雄,廣瀬 悦子,白井 憲司,菊池 新,道和 百合,杉浦 弘,元重 京子,大木 茂
  • 日本未熟児新生児学会雑誌 = Journal of Japan Society for Premature and Newborn Medicine 21(1), 113-119, 2009-02-15
  • NAID 10025626366
  • Bilirubin encephalopathy : A study of neuronal subpopulations and neurodegenerative mechanisms in 12 autopsy cases
  • HACHIYA Yasuo,HAYASHI Masaharu
  • Brain & development 30(4), 269-278, 2008-04-01
  • NAID 10025169841


The Kernicterus Program at Children's Mercy provides a full range of diagnostic services, treatment options, and support services for patients diagnosed with kernicterus. About Kernicterus Kernicterus is a form of brain damage ...
kernicterus /ker·nic·ter·us/ (ker-nik´ter-us) [Ger.] a condition with severe neural symptoms, associated with high levels of bilirubin in the blood. ker·nic·ter·us (kûr-n k t r-s) n. A grave form of jaundice of the newborn characterized by ...


Chapter 25: KernicterusDescription Kernicterus.jpgKernícterusDisplaying 18> Images For - Kernicteruskernicterus kernicterus bilirubin staining 所属词条 > 小儿黄疸

リンク元核黄疸」「nuclear jaundice」「nuclear icterus



kernicterus, nuclear jaundice, nuclear icterus
ビリルビン脳症 bilirubin encephalopathy

小児科学第2版 p.423-


  • 新生児において高度の高間接ビリルビン血症(5mg/dL異常)の持続により、血管脳肝門を通過したビリルビンが脳に蓄積して生じる。生後3-7日で症状が出現する。


  • 急性ビリルビン脳症(核黄疸)
  • 1期(発病約2-3日)
  • 嗜眠、筋緊張低下、吸啜反射減弱
  • 2期(発病約3-1週)
  • 3期(発病約1週以降)
  • 筋緊張亢進症状消失
  • 慢性ビリルビン脳症(核黄疸後遺症)
  • 過渡的症状(約1年以内)
  • ほ乳不良、甲高い鳴き声、筋緊張低下(深部反射亢進)、運動発達千円
  • 核黄疸後遺症(約1.5年以降)



出生体重  光線療法  交換療法
<1,500g 0.3μg/dl 0.8μg/dl
≧1,500g 0.6μg/dl 1.0μg/dl
  • 光線療法
  • 光によりビリルビンが光学異性体となり、血流に入る
  • 適応


  • 第1期症状(Moro反射が消失し元気がなくなる)で治療を行えば、障害は防ぐことができる。
  • 後弓反張や落陽現象、痙攣など神経学的所見が明らかになった症例では、アテトーゼを伴う脳性小児麻痺、高温域の感音性難聴の後遺症を残すリスクが高い。

nuclear jaundice」


kernicterusnuclear icterus

nuclear icterus」


kernicterusnuclear jaundice