insulin-like growth factor II receptor

出典: meddic

IGF type 2 receptorIGF-2 receptorIGF-II receptormannose 6-phosphate receptor

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英文文献

  • New therapeutic agents for acromegaly.
  • Melmed S1.
  • Nature reviews. Endocrinology.Nat Rev Endocrinol.2015 Nov 27. doi: 10.1038/nrendo.2015.196. [Epub ahead of print]
  • The currently available somatostatin receptor ligands (SRLs) and growth hormone (GH) antagonists are used to control levels of GH and insulin-like growth factor 1 (IGF-1) in patients with acromegaly. However, these therapies are limited by wide variations in efficacy, associated adverse effects and
  • PMID 26610414
  • CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death.
  • Chen WK1, Kuo WW2, Hsieh DJ3, Chang HN4, Pai PY5, Lin KH6,7,8, Pan LF9,10, Ho TJ11,12, Viswanadha VP13, Huang CY14,15,16.
  • International journal of molecular sciences.Int J Mol Sci.2015 Nov 24;16(11):27921-27930.
  • During hypoxia, gene expression is altered by various transcription factors. Insulin-like growth factor-II (IGF2) is known to be induced by hypoxia, which binds to IGF2 receptor IGF2R that acts like a G protein-coupled receptor, might cause pathological hypertrophy or activation of the mitochondria-
  • PMID 26610485
  • Targeting cholesterol with β-cyclodextrin sensitizes cancer cells for apoptosis.
  • Yamaguchi R1, Perkins G2, Hirota K3.
  • FEBS letters.FEBS Lett.2015 Nov 19. pii: S0014-5793(15)01013-3. doi: 10.1016/j.febslet.2015.11.009. [Epub ahead of print]
  • We found that targeting cholesterol with beta-cyclodextrin (bCD) and its derivatives disrupted signal transduction between PI3K and AKT, attenuating AKT pro-survival signals. In their absence, 2-deoxyglucose (2DG) caused anti-apoptotic protein Mcll to dissociate from pro-apoptotic Bak at mitochondri
  • PMID 26606906

和文文献

  • Expression of Insulin-like Growth Factor (IGF) Family Members in Porcine Pregnancy
  • MIESE-LOOY Germaine,VAN DEN HEUVEL Marianne J.,EDWARDS Andrew K.,LAMARRE Jonathan,TAYADE Chandrakant
  • Journal of Reproduction and Development 58(1), 51-60, 2012
  • … Adequate vascularization of the attachment site has emerged as a key factor contributing to fetal success. … Since Insulin-Like Growth Factor (IGF) family members regulate angiogenesis in addition to promoting fetal development and growth, we hypothesized that conceptus success is governed by members of the IGF family. …
  • NAID 130000845794
  • Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers
  • WANG Yu,ADACHI Yasushi,IMSUMRAN Arisa,YAMAMOTO Hiroyuki,PIAO Wenhua,LI Hua,II Masanori,ARIMURA Yoshiaki,PARK Mi Young,KIM Dalrae,LEE Choon-Taek,CARBONE David P.,IMAI Kohzoh,SHINOMURA Yasuhisa
  • Journal of gastroenterology 45(2), 159-170, 2010-02-01
  • NAID 10027214385
  • Prostaglandin F2.ALPHA. Differentially Affects mRNA Expression Relating to Angiogenesis, Vasoactivation and Prostaglandins in the Early and Mid Corpus Luteum in the Cow
  • SHIRASUNA Koumei,SASAHARA Kiemi,MATSUI Motozumi,SHIMIZU Takashi,MIYAMOTO Akio
  • Journal of Reproduction and Development 56(4), 428-436, 2010
  • … up-regulated the mRNA expressions of angiogenic-related factors such as vascular endothelial growth factors, vasohibin, fibroblast growth factor 2 and insulin-like growth factor-II in the early CL, whereas PGF<sub>2</sub><sub>α</sub> … receptor mRNA expression in both regions of the early and mid CL. …
  • NAID 130000256775

関連リンク

... (1987). "Insulin-like growth factor II receptor as a multifunctional binding protein". Nature 329 (6137): 301–7. doi:10.1038/329301a0. PMID 2957598. Oshima A, Nolan CM, Kyle JW, et al. (1988). "The human cation-independent ...
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2

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★リンクテーブル★
リンク元mannose 6-phosphate receptor」「インスリン様増殖因子II受容体」「IGF-II receptor」「IGF-2 receptor」「IGF type 2 receptor
関連記事like」「grow」「growth」「factor」「fact

mannose 6-phosphate receptor」

  [★]

  • マンノース6リン酸受容体、マンノース6リン酸レセプター
IGF type 2 receptorIGF-2 receptorIGF-II receptorinsulin-like growth factor II receptorMPR

インスリン様増殖因子II受容体」

  [★]

insulin-like growth factor II receptor
マンノース6リン酸受容体、IGF受容体2型IGF-2受容体IGF-II受容体インスリン様増殖因子IIレセプター

IGF-II receptor」

  [★]

IGF type 2 receptorIGF-2 receptorinsulin-like growth factor II receptormannose 6-phosphate receptor


IGF-2 receptor」

  [★]

IGF type 2 receptorIGF-II receptorinsulin-like growth factor II receptormannose 6-phosphate receptor

IGF type 2 receptor」

  [★]

IGF-2 receptorIGF-II receptorinsulin-like growth factor II receptormannose 6-phosphate receptor

like」

  [★]

  • v.
  • prep.
alikeas well ascare forcorrespondcorrespondinglyequallyfavoridenticallylikewisepreferresemblesamesimilarsimilarlysuch

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「want to have; "I''d like a beer now!"」

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「a kind of person; "We''ll not see his like again"; "I can''t tolerate people of his ilk"」
ilk

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「a similar kind; "dogs, foxes, and the like", "we don''t want the likes of you around here"」
the like, the likes of

PrepTutorEJDIC   license prepejdic

「…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事」

PrepTutorEJDIC   license prepejdic

「(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように」

WordNet   license wordnet

「equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number"」
same

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「resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality"」
similar

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「be fond of; "I like my nephews"」

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「feel about or towards; consider, evaluate, or regard; "How did you like the President''s speech last night?"」

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「find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"」

grow」

  [★]

  • v.
(過去: grew-過去分詞: grown)
extendgrowthoutgrowoutgrowthstretch

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「cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here"」
raise, farm, produce

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「come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts"」
develop, produce, get, acquire

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「become attached by or as if by the process of growth; "The tree trunks had grown together"」

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「become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"」

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「cause to grow or develop; "He grows vegetables in his backyard"」

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「increase in size by natural process; "Corn doesn''t grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesn''t grow much anymore"」

PrepTutorEJDIC   license prepejdic

「『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)」

growth」

  [★]

  • n.
  • 成長


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「(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children"」
growing, maturation, development, ontogeny, ontogenesis

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「(pathology) an abnormal proliferation of tissue (as in a tumor)」

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「a progression from simpler to more complex forms; "the growth of culture"」

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「something grown or growing; "a growth of hair"」

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「vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"」

PrepTutorEJDIC   license prepejdic

「〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)」

factor」

  [★]

  • n.
elementelementaryfactorialparameter

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「be a contributing factor; "make things factor into a company''s profitability"」

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「any of the numbers (or symbols) that form a product when multiplied together」

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「an independent variable in statistics」

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「anything that contributes causally to a result; "a number of factors determined the outcome"」

PrepTutorEJDIC   license prepejdic

「(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize」

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「consider as relevant when making a decision; "You must factor in the recent developments"」
factor in, factor out

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「resolve into factors; "a quantum computer can factor the number 15"」
factor in, factor out


fact」

  [★]

  • n.
actualactuallyin factin practiceindeedpractically

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「an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"」

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「a concept whose truth can be proved; "scientific hypotheses are not facts"」

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「a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"」

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「a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"」

PrepTutorEJDIC   license prepejdic

「〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行」




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