total iron binding capacity

総鉄結合能

WordNet

1. the amount that can be contained; "the gas tank has a capacity of 12 gallons" (同)content
2. (computer science) the amount of information (in bytes) that can be stored on a disk drive; "the capacity of a hard disk drive is usually expressed in megabytes"
3. a specified function; "he was employed in the capacity of director"; "he should be retained in his present capacity at a higher salary"
4. the maximum production possible; "the plant is working at 80 per cent capacity"
5. tolerance for alcohol; "he had drunk beyond his capacity"
6. the power to learn or retain knowledge; in law, the ability to understand the facts and significance of your behavior (同)mental ability
7. capability to perform or produce; "among his gifts is his capacity for true altruism"; "limited runway capacity"; "a great capacity for growth"
8. press and smooth with a heated iron; "press your shirts"; "she stood there ironing" (同)iron_out, press
9. a heavy ductile magnetic metallic element; is silver-white in pure form but readily rusts; used in construction and tools and armament; plays a role in the transport of oxygen by the blood (同)Fe, atomic number 26
10. implement used to brand live stock (同)branding iron
11. home appliance consisting of a flat metal base that is heated and used to smooth cloth (同)smoothing iron
12. a golf club that has a relatively narrow metal head
13. executed with proper legal authority; "a binding contract"
14. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
15. strip sewn over or along an edge for reinforcement or decoration
16. the capacity to attract and hold something
17. determine the sum of; "Add all the people in this town to those of the neighboring town" (同)tot, tot up, sum, sum_up, summate, tote up, add, add together, tally, add up
18. damage beyond the point of repair; "My son totaled our new car"; "the rock star totals his guitar at every concert"
19. add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000" (同)number, add up, come, amount
20. garments (clothes or linens) that are to be (or have been) ironed; "there was a basketful of ironing to do"
21. the work of using heat to smooth washed clothes in order to remove any wrinkles

PrepTutorEJDIC

1. 〈U〉《しばしばa capacity》(建物などの)『収容力』,(容器などの)『容量』,『容積』 / 〈U〉《しばしばa capacity》(人の)『能力』,才能;(物の)性能 / 〈C〉(…の)『資格』,地位《+『of』(『as』)+『名』》
2. 〈U〉『鉄』 / 〈U〉鉄のように堅い(強い,冷たい)こと / 〈C〉鉄製の器具 / 〈C〉[電気]『アイロン』 / 〈C〉アイアン(球を打つ部分が金属のゴルフクラブ) / 〈C〉《複数形で》手かせ,足かせ / 《名詞の前にのみ用いて》『鉄の』,鉄製の / 鉄のように堅い(強い,冷たい) / …‘に'アイロンをかける / 〈人が〉アイロンをかける
3. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
4. 『総計の』,全体の / 『全くの』,完全な(absolute) / 『合計』,総額,総数,総量(sum) / …‘を'合計する / 合計…‘に'なる,総額が…‘に'のぼる(amount to)
5. アイロンかけ / アイロンかけをした(をする)衣類

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/28 03:32:56」(JST)

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Total iron-binding capacity
Diagnostics
transferrin
MedlinePlus	003489
LOINC	14800-7, 35215-3, 2501-5

Total iron-binding capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It is performed by drawing blood and measuring the maximum amount of iron that it can carry, which indirectly measures transferrin since transferrin is the most dynamic carrier. TIBC is less expensive than a direct measurement of transferrin.

The TIBC should not be confused with the UIBC, or "unsaturated iron binding capacity" (22753-8 and 35216-1). The UIBC is calculated by subtracting the serum iron from the TIBC.

Interpretation

Taken together with serum iron and percent transferrin saturation clinicians usually perform this test when they are concerned about anemia, iron deficiency or iron deficiency anemia. However, because the liver produces transferrin, alterations in function (such as cirrhosis, hepatitis, or liver failure) must be considered when performing this test. It can also be an indirect test of liver function, but is rarely used for this purpose.

The percent transferrin saturation (i.e., the result of the formula of serum iron/TIBC x 100) can also be a useful indicator.

Condition	Serum iron	Transferrin and TIBC	Percent transferrin saturation
iron deficiency anemia	Low	High. The liver produces more transferrin, presumably attempting to maximize use of the little iron that is available.	Low, as there is insufficient iron.
anemia of chronic disease	Low, as the body holds iron intracellularly with ferritin.	Low. The body produces less transferrin (but more ferritin), presumably to keep iron away from pathogens that require it for their metabolism. This is mainly regulated by increased hepcidin production.	Normal
pregnancy or use of hormonal contraception, but without iron deficiency	Normal	High. The liver increases the production of transferrin, thus raising TIBC.	Low, as there is excess transferrin with normal serum iron levels.

These examples demonstrate that to properly understand a value for TIBC, one also must know the serum iron, the percent transferrin saturation, and the individual clinical situation.

Usual values

Reference ranges for blood tests, comparing blood content of iron and related compounds (shown in brown and orange) with other constituents.

Normal reference ranges are:

• Serum iron: Male 65–177 μg/dL (11.6–31.7 μmol/L); Female 50–170 μg/dL (9.0–30.4 μmol/L)
• TIBC: 250–370 μg/dL (45-66 μmol/L)
• Transferrin saturation: Male 20–50%; Female 15–50%
• Serum ferritin: Male 20-250 μg/L, Female 15-150 μg/L

μg/dL = micrograms per deciliter; μmol/L = micromoles per litre.

Laboratories often use different units and "normal" may vary by population and the lab techniques used. Look at the individual laboratory reference values to interpret a specific test (for instance, your own).

References

UpToDate Contents

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• 1. 鉄欠乏性貧血の原因および診断 causes and diagnosis of anemia due to iron deficiency
• 2. 鉄のバランス調節 regulation of iron balance
• 3. 慢性疾患の貧血（慢性炎症時の貧血） anemia of chronic disease anemia of chronic inflammation
• 4. 乳幼児における鉄欠乏：スクリーニング、予防、臨床症状、および診断 iron deficiency in infants and young children screening prevention clinical manifestations and diagnosis
• 5. 鉄過剰症候群の病態生理および診断 pathophysiology and diagnosis of iron overload syndromes

English Journal

• Iron in Relation to Gastric Cancer in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.

• Cook MB, Kamangar F, Weinstein SJ, Albanes D, Virtamo J, Taylor PR, Abnet CC, Wood RJ, Petty G, Cross AJ, Dawsey SM.SourceAuthors' Affiliations: 1Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda; 2Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore; 3School of Public Health and Health Sciences, University of Massachusetts; 4Nutrition Evaluation Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts; and 5Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
• Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.Cancer Epidemiol Biomarkers Prev.2012 Oct 22. [Epub ahead of print]
• BACKGROUND: Iron is an essential micronutrient that can have carcinogenic effects when at high or low concentrations. Previous studies of iron in relation to gastric cancer have not assessed subtype-specific relationships. We used the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Preven
• PMID 23001240

• Association of total iron binding capacity with coronary artery disease.

• Kang P, Liu T, Tian C, Zhou Y, Jia C.SourceDepartment of Epidemiology and Health Statistics, Shandong University, PR China.
• Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2012 Oct 9;413(19-20):1424-9. Epub 2012 May 28.
• OBJECTIVE: A case-control study and a meta-analysis were conducted to assess the association between total iron binding capacity (TIBC) and coronary artery disease (CAD) risk.METHODS: A hospital-based case-control study was conducted with 258 CAD cases and 282 healthy controls. Logistic regression w
• PMID 22652366

Japanese Journal

• Feature on Erythropoiesis in Dietary Restricted Rats

• Asanuma Fumiko,Miyata Hiroto,Iwaki Yoshinobu [他],KIMURA Masaaki
• 日本獣醫學会会誌 73(1), 89-96, 2011
• … phlebotomy groups in which 1% or 4% of total blood volume was removed by serial phlebotomy for 14 days (PB01 and PB04); … Decreases in peripheral blood reticulocytes, bone marrow erythroids and the unsaturated iron binding capacity (UIBC) were observed as changes that suppressed erythropoiesis in the R33 and R66 groups. …
• NAID 40018701688

• Acidic Xylooligosaccharide Preserves Hepatic Iron Storage Level in Adult Female Rats Fed a Low-Iron Diet

• Kobayashi Yukiko,Ohbuchi Takayuki,Fukuda Tomo [他],WAKASUGI Etsuko,YASUI Risa,HAMADA Mai,YOKOYAMA Meiko,KUWAHATA Masashi,KIDO Yasuhiro
• Journal of Nutritional Science and Vitaminology 57(4), 292-297, 2011
• … Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. … This experiment was conducted to investigate whether acidic xylooligosaccharide (U-XOS), expected to have a high iron bioavailability, was useful in the prevention of iron deficiency. … a U-XOS-supplemented low-iron diet (LI-X, n=7), a low-iron diet (LI, n=6), and a control diet (C, n=6). …
• NAID 130001373001

• 血液透析患者における二次性副甲状腺機能亢進症に対するシナカルセト投与が貧血に及ぼす影響

• 大坪 茂,矢島 愛治,内藤 順代 [他],石原 美和,植田 修逸,杉本 久之,大坪 公子,木全 直樹,内田 啓子,秋葉 隆,新田 孝作
• 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 43(6), 501-506, 2010-06-28
• 【目的】エリスロポエチン抵抗性貧血の原因の一つとして，二次性副甲状腺機能亢進症が知られている．シナカルセトは2008年に日本で使用可能となった二次性副甲状腺機能亢進症に対する新しい薬剤である．今回，シナカルセトが腎性貧血における赤血球生成刺激剤の反応性を改善させるか検討した．【方法】シナカルセトを1年以上使用した20名を対象とし，開始前，開始後1，4，8，12か月後のintact parathyr …
• NAID 10026912641

Related Links

• Total iron-binding capacity - Wikipedia, the free encyclopedia

Total iron-binding capacity (TIBC) is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. It is performed by drawing blood and measuring the maximum amount of iron that it can carry, which indirectly ...

• Total iron binding capacity: MedlinePlus Medical Encyclopedia

Total iron binding capacity (TIBC) is a blood test to see if you may have too much or too little iron in the blood. Iron moves through the blood attached to a protein called transferrin. This test helps your doctor know how well that protein can carry  ...

Related Pictures

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★リンクテーブル★

リンク元	「総鉄結合能」「TIBC」
関連記事	「binding」「capacity」「total」「iron」

「総鉄結合能」

　　[★]

英

total iron binding capacity, TIBC

関

鉄結合能、鉄、貧血, UIBC

概念

• 血液中で鉄はトランスフェリンと結合して運搬されるが、そのトランスフェリンが結合可能な鉄の総量。
• 血液中に存在するトランスフェリンが鉄を結合しうる能力を示している。
• TIBC = UIBC + Fe の関係がある。

基準値

臨床検査法提要第32版

• 262-452 ug/dL 血清

HIM.A-6

• 251-406 ug/dL 血清

「TIBC」

　　[★] 総鉄結合能 total iron binding capacity

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「capacity」

　　[★]

• n.

• 能力、容量

(呼吸器)volumeの和・差はcapacityと呼ぶ傾向があるみたい

• ex.

• functional residual capacity, FRC

関

ability、capability、capacitance、competence、competent、facility、power

　 　 　 　 　 　 　 　

「total」

　　[★]

• n.

• 全体、総量、総、全

関

all、altogether、common、entire、entirety、gross、overall、total amount、whole

　 　 　 　

「iron」

　　[★] 鉄