可逆的共有結合修飾
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- 1. 喘息の遺伝学genetics of asthma [show details]
…expression due to non-coding changes to the DNA) . As an example, DNA methylation, a reversible covalent modification of DNA in which a methyl group is transferred from S-adenosylmethionine to cytosine …
- 2. 可逆性後白質脳症症候群reversible posterior leukoencephalopathy syndrome [show details]
… It is also often referred to as: Posterior reversible encephalopathy syndrome (PRES) Reversible posterior cerebral edema syndrome; Posterior leukoencephalopathy syndrome; Hyperperfusion encephalopathy; …
- 3. 肝疾患を有する患者における化学療法による肝毒性および用量調整chemotherapy hepatotoxicity and dose modification in patients with liver disease [show details]
…Abnormalities have generally been reversible with dose interruption. Close monitoring of LFTs, especially during the first three months of treatment, is recommended. Dose modification guidelines for hepatotoxicity …
- 4. 腎不全患者に生じる抗がん剤の腎毒性と用量調整：分子標的治療薬chemotherapy nephrotoxicity and dose modification in patients with renal insufficiency molecularly targeted agents [show details]
… and recommended dose modifications in patients with renal insufficiency. Nephrotoxicity and renal dose modification for conventional chemotherapeutic drugs,… Cyst development appears to be reversible upon discontinuation of the drug,…
- 5. 腎不全患者に生じる抗がん剤の腎毒性と用量調整：既存の細胞障害性抗癌剤chemotherapy nephrotoxicity and dose modification in patients with renal insufficiency conventional cytotoxic agents [show details]
… and recommended dose modifications in patients with renal insufficiency will be reviewed here.… pemetrexed . Baseline renal impairment appears to be a risk factor for AKI . Some cases may not be reversible . Pemetrexed is primarily excreted unchanged by renal excretion. Dose adjustment is not necessary …
English Journal
- A Highly Efficient Self-Healing Elastomer with Unprecedented Mechanical Properties.
- Zhang L, Liu Z, Wu X, Guan Q, Chen S, Sun L, Guo Y, Wang S, Song J, Jeffries EM, He C, Qing FL, Bao X, You Z.
- Advanced materials (Deerfield Beach, Fla.). 2019 Apr;()e1901402.
- It is highly desirable, although very challenging, to develop self-healable materials exhibiting both high efficiency in self-healing and excellent mechanical properties at ambient conditions. Herein, a novel Cu(II)-dimethylglyoxime-urethane-complex-based polyurethane elastomer (Cu-DOU-CPU) with syn
- PMID 30977571
- Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.
- Mondal S, Thompson PR.
- Accounts of chemical research. 2019 Mar;52(3)818-832.
- Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group of hydrolases called protein arginine deiminases (PADs). Hundreds of proteins are known to be citrullinated and hypercitrulli
- PMID 30844238
- Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations.
- Bensinger D, Stubba D, Cremer A, Kohl V, Waßmer T, Stuckert J, Engemann V, Stegmaier K, Schmitz K, Schmidt B.
- Journal of medicinal chemistry. 2019 Mar;62(5)2428-2446.
- The use of covalent irreversible binding inhibitors is an established concept for drug development. Usually, the discovery of new irreversible kinase inhibitors occurs serendipitously, showing that efficient rational approaches for the rapid discovery of new drugs are needed. Herein, we report a vir
- PMID 30742435
Japanese Journal
- Human Serum Albumin as an Antioxidant in the Oxidation of (-)-Epigallocatechin Gallate : Participation of Reversible Covalent Binding for Interaction and Stabilization
- Ishii Takeshi,Ichikawa Tatsuya,Minoda Kanako [他],KUSAKA Koji,ITO Sohei,SUZUKI Yukiko,AKAGAWA Mitsugu,MOCHIZUKI Kazuki,GODA Toshinao,NAKAYAMA Tsutomu
- Bioscience, biotechnology, and biochemistry 75(1), 100-106, 2011-01-23
- … These results suggest the reversible covalent modification of EGCg <I>via</I> …
- NAID 10027896843
- Aspergillus niger結晶α-グルコシダーゼの構造と機能に関する研究
- 木村 淳夫
- 応用糖質科学 45(1), 71-79, 1998
- … The essential ionizable groups in the active site were identified to be -COO- and -COOH by the kinetic studies and the chemical modification technique using water-soluble carbodiimide. … One set of S-S bridges in P1 and two of those with one free Cys in P2 were identified with a chemical modification analysis using fluorescent SH reagents. … Two subunits were not linked with disulfide bond, which suggests that P1 and P2 are tightly bound by non-covalent linkage to make a three-dimensional structure. …
- NAID 130004257547
- A Catalytic Amino Acid and Primary Structure of Active Site in Aspergillus niger α-Glucosidase
- Kimura Atsuo,Takata Masuhiro,Fukushi Yukiharu [他],MORI Haruhide,MATSUI Hirokazu,CHIBA Seiya
- Bioscience, biotechnology, and biochemistry 61(7), 1091-1098, 1997-07-23
- … The catalytic amino acid residue of Aspergillus niger α-glucosidase (ANGase) was identified by modification with conduritol B epoxide (CBE), a mechanism-based irreversible inactivator. … The interaction of CBE and ANGase conformed to a model with a reversible enzyme-inhibitor complex formed before covalent inactivation. …
- NAID 110002678653
Related Links
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- Covalent modifications to enzymes | Biomolecules | MCAT | Khan Academy khanacademymedicine Loading... Covalent Modification - Reversible - Duration: 12:56. Moof University 20,273 views 12:56 Allosteric regulation and ...
★リンクテーブル★
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- 英
- reversible covalent modification
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不可逆的共有結合修飾
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不可逆的共有結合修飾
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可逆的共有結合修飾
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- 関
- alter、alteration、amend、amendment、change、metamorphic、metamorphosis、metamorphotic、modify、revise、revision
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- 関
- covalency、covalent attachment、covalent binding、covalent bond、covalently
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- 関
- reversibility、reversibly