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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/13 02:57:55」(JST)

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Synchronizing nonfouling and antimicrobial properties in a zwitterionic hydrogel.

Mi L, Jiang S.SourceDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Biomaterials.Biomaterials.2012 Dec;33(35):8928-33. doi: 10.1016/j.biomaterials.2012.09.011. Epub 2012 Sep 20.
In this work, we report a new approach to integrate antimicrobial and nonfouling properties into a single platform without compromising each other. To achieve this, a zwitterionic hydrogel is conjugated with an antimicrobial agent as a leaving group in a way that maintains the zwitterionic form of t
PMID 22999466

Synthetic farnesoid x receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.

Hambruch E, Miyazaki-Anzai S, Hahn U, Matysik S, Boettcher A, Perovic-Ottstadt S, Schlüter T, Kinzel O, Krol HD, Deuschle U, Burnet M, Levi M, Schmitz G, Miyazaki M, Kremoser C.SourcePhenex Pharmaceuticals AG, Waldhofer Str. 104, 69123 Heidelberg, Germany. claus.kremoser@phenex-pharma.com.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 Dec;343(3):556-67. doi: 10.1124/jpet.112.196519. Epub 2012 Aug 23.
Farnesoid X receptor (FXR), a bile acid-activated nuclear hormone receptor, plays an important role in the regulation of cholesterol and more specifically high-density lipoprotein (HDL) homeostasis. Activation of FXR is reported to lead to both pro- and anti-atherosclerotic effects. In the present s
PMID 22918042