同: HOA

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/31 15:26:25」(JST)

wiki en

This article is about hypertrophic osteopathy in animals. For hypertrophic osteopathy in humans, see Nail clubbing.

Hypertrophic osteopathy is a bone disease secondary to cancer in the lungs.

Presentation

It is characterized by new bone formation on the outside of the diaphyses of long bones of the limbs, without destruction of cortical bone. Symptoms include stiffness and warm, firm swelling of the legs, and signs of lung disease such as coughing and difficulty breathing. Hypertrophic osteopathy in humans differs from a similar condition in dogs, in that in humans it is usually caused by lung tumors or infections such as Mycobacterium fortuitum or Corynebacterium. The most common cause in dogs is primary or metastatic pulmonary neoplasia.^[1] Other potential causes in dogs include heartworm disease, heart disease, and pulmonary abscesses.^[2] It has also been associated with nonpulmonary diseases such as renal tumors and rhabdomyosarcoma of the bladder.^[3] At least once it has been caused by congenital megaesophagus in a six year old dog.^[4] Hypertrophic osteopathy is rare in cats.^[5]

Causes

One theory is that hypertrophic osteopathy is caused by increased blood flow to the ends of the legs, overgrowth of connective tissue, and then new bone formation surrounding the bones.^[6] This is secondary to nerve stimulation by the lung disease. The condition may reverse if the lung mass is removed or if the vagus nerve is cut on the affected side.

References

^ Foster, Wendy K.; Armstrong, Julie A. (2006). "Hypertrophic osteopathy associated with pulmonary Eikenella corrodens infection in a dog". Journal of the American Veterinary Medical Association 228 (9): 1366–1369. doi:10.2460/javma.228.9.1366. PMID 16649940. http://avmajournals.avma.org/doi/abs/10.2460/javma.228.9.1366. Retrieved 2006-08-26.
^ Anderson T, Walker M, Goring R (2004). "Cardiogenic hypertrophic osteopathy in a dog with a right-to-left shunting patent ductus arteriosus". J Am Vet Med Assoc 224 (9): 1464–6, 1453. doi:10.2460/javma.2004.224.1464. PMID 15124887.
^ Seaman R, Patton C (2003). "Treatment of renal nephroblastoma in an adult dog". J Am Anim Hosp Assoc 39 (1): 76–9. PMID 12549618.
^ Watrous B, Blumenfeld B (2002). "Congenital megaesophagus with hypertrophic osteopathy in a 6-year-old dog". Vet Radiol Ultrasound 43 (6): 545–9. doi:10.1111/j.1740-8261.2002.tb01046.x. PMID 12502108.
^ Becker T, Perry R, Watson G (1999). "Regression of hypertrophic osteopathy in a cat after surgical excision of an adrenocortical carcinoma". J Am Anim Hosp Assoc 35 (6): 499–505. PMID 10580910.
^ Foster W, Armstrong J (2006). "Hypertrophic osteopathy associated with pulmonary Eikenella corrodens infection in a dog". J Am Vet Med Assoc 228 (9): 1366–9. doi:10.2460/javma.228.9.1366. PMID 16649940.

This veterinary medicine–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 悪性腫瘍およびリウマチ性疾患 malignancy and rheumatic disorders
2. 内臓悪性腫瘍の皮膚症状 cutaneous manifestations of internal malignancy
3. 肺癌の危険因子、病理、および臨床症状の概要 overview of the risk factors pathology and clinical manifestations of lung cancer
4. 間質性肺疾患を有する成人に対するアプローチ：臨床的評価 approach to the adult with interstitial lung disease clinical evaluation
5. サルコイド：筋肉、骨、血管の疾患の徴候 sarcoid muscle bone and vascular disease manifestations

English Journal

The seminal role played by Pierre Marie in Neurology and Internal Medicine.

Almeida GM1, Germiniani FM1, Teive HA1.
Arquivos de neuro-psiquiatria.Arq Neuropsiquiatr.2015 Oct;73(10):887-9. doi: 10.1590/0004-282X20150126. Epub 2015 Sep 1.
The authors review the most important contributions of Pierre Marie to the elucidation and description of several neurological diseases, such as Charcot-Marie-Tooth's disease and hereditary cerebellar ataxia, as well as his contributions to Internal Medicine, including his pioneering studies on acro
PMID 26331384

A Common Mutation and a Novel Mutation in the HPGD Gene in Nine Patients with Primary Hypertrophic Osteoarthropathy.

Yuan L1, Chen L1, Liao RX1, Lin YY1,2, Jiang Y1, Wang O1, Li M1, Xing XP1, Pang QQ1,2, Jiajue R1, Xia WB3.
Calcified tissue international.Calcif Tissue Int.2015 Oct;97(4):336-42. doi: 10.1007/s00223-015-0024-3. Epub 2015 Jul 2.
Primary hypertrophic osteoarthropathy (PHO) is a hereditary bone disease characterized by digital clubbing, periostosis, and pachydermia. The HPGD gene encoding 15-prostaglandin dehydrogenase and SLCO2A1 encoding one type of prostaglandin transporter were found to be responsible for PHO. Mutations o
PMID 26135126

Hypertrophic osteoarthropathy with imatinib therapy.

Cundy T1, Porter D2, Grey A1.
Internal medicine journal.Intern Med J.2015 Oct;45(10):1088-90. doi: 10.1111/imj.12858.
PMID 26429221

Japanese Journal

肺性肥大性骨関節症を合併した肺多形癌の1例

井原大輔,服部登,吉岡宏治,藤高一慶,河野修興
日本呼吸器学会雑誌 = The journal of the Japanese Respiratory Society 49(10), 765-769, 2011-10-10
NAID 10029830027

症例骨転移と考えられた肺性肥大性骨関節症を伴う原発性肺癌の1例

湯木毅,阪本俊彦
胸部外科 64(9), 860-863, 2011-08
NAID 40018928833

Related Pictures

★リンクテーブル★

リンク元	「肥厚性骨関節症」「肥大性骨関節症」「肥厚性骨関節障害」
拡張検索	「primary hypertrophic osteoarthropathy」「secondary hypertrophic osteoarthropathy」
関連記事	「osteoarthropathy」「hypertrophic」