ヒトTリンパ球向性ウイルス、ヒトTリンパ球好性ウイルス、ヒトTリンパ好性ウイルス

関: HTLV、human T-cell leukemia virus、human T-cell lymphotropic virus

WordNet

sing with closed lips; "She hummed a melody"
a humming noise; "the hum of distant traffic" (同)humming
be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
sound with a monotonous hum (同)thrum
make a low continuous sound; "The refrigerator is humming"
relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
characteristic of humanity; "human nature"
having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"
a harmful or corrupting agency; "bigotry is a virus that must not be allowed to spread"; "the virus of jealousy is latent in everyone"
(virology) ultramicroscopic infectious agent that replicates itself only within cells of living hosts; many are pathogenic; a piece of nucleic acid (DNA or RNA) wrapped in a thin coat of protein
a software program capable of reproducing itself and usually capable of causing great harm to files or other programs on the same computer; "a true virus cannot spread to another computer without human assistance" (同)computer virus
the 20th letter of the Roman alphabet (同)t
a tough youth of 1950s and 1960s wearing Edwardian style clothes (同)Teddy boy

PrepTutorEJDIC

〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
(動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類
ビールス,ろ過性病原体
tritiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/01 13:10:45」(JST)

wiki en

[Wiki en表示]

The Human T-lymphotropic virus Type I (HTLV-1) is a human RNA retrovirus that is known to cause a type of cancer, referred to as adult T-cell leukemia and lymphoma, and a demyelinating disease called HTLV-I associated myelopathy/Tropical spastic paraparesis (HAM/TSP). HTLV-I is one of a group of closely related primate T lymphotropic viruses (PTLVs). Members of this family that infect humans are called Human T-lymphotropic viruses, and the ones that infect old-world primates are called Simian T-lymphotropic viruses. To date, four types of HTLVs (HTLV-I, HTLV-II, HTLV-III, and HTLV-IV) and four types of STLVs (STLV-I, STLV-II, STLV-III, and STLV-IV) have been identified. The HTLVs are believed to originate from intraspecies transmission of STLVs. The original name for HIV, the virus that causes AIDS, was HTLV-III; this term is no longer in use [1]. The HTLV-1 genome is diploid, composed of two copies of a single-stranded RNA virus whose genome is copied into a double-stranded DNA form that integrates into the host cell genome, at which point the virus is referred to as a provirus. A closely related virus is bovine leukemia virus BLV.

HTLV-I

Main article: Human T-lymphotropic virus 1

HTLV-I is an abbreviation for the human T-cell lymphotropic virus type 1, also called the Adult T-cell lymphoma virus type 1, a virus that has been seriously implicated in several kinds of diseases, including HTLV-I-associated myelopathy and Strongyloides stercoralis, and as a virus cancer link for leukemia (see adult T-cell leukemia/lymphoma). Between 1 in 20 and 1 in 25 infected persons are thought to develop cancer as a result of the virus.^{[citation needed]}^[1]

HTLV-II

Main article: Human T-lymphotropic virus 2

A virus closely related to HTLV-I, HTLV-II shares approximately 70% genomic homology(structural similarity) with HTLV-I.

HTLV-III and HTLV-IV

When HIV, the virus that causes AIDS, was characterized in 1984 by Robert Gallo [2], he named it HTLV-III. HTLV-III is currently the name used to describe another virus related to HTLV-I and HTLV-II. "HTLV-IV" has been used to describe recently characterized viruses.^[2]^[3]^[4]

These viruses were discovered in 2005 in rural Cameroon, and were, it is presumed, transmitted from monkeys to hunters of monkeys through bites and scratches.

HTLV-III is similar to STLV-III (Simian T-lymphotropic virus 3).^[5] Multiple strains have been identified.^[6] It expresses gag, pol, and env, among other proteins.^[7]

HTLV-IV does not resemble any known virus.

It is not yet known how much further transmission has occurred among humans, or whether the viruses can cause disease.

The use of these names can cause some confusion, because the name HTLV-III was one of the names for HIV in early AIDS literature, but has since fallen out of use.^[8] The name HTLV-IV has also been used to describe HIV-2.^[9]

Transmission

HTLV-I and HTLV-II are sexually transmitted.^[10]^[11]

References

^ WELSH, JAMES S. (January 2011). "Contagious Cancer". The Oncologist 16 (1): 1-4. doi:10.1634/theoncologist.2010-0301. PMID 21212437.
^ Mahieux, R; Gessain, A (2005). "Les nouveaux rétrovirus humains HTLV-3 et HTLV-4 [New human retroviruses: HTLV-3 and HTLV-4]" (in French). Médecine tropicale 65 (6): 525–8. PMID 16555510. http://www.revuemedecinetropicale.com/525-528_-_av_-_mahieux.pdf.
^ Calattini, S.; Chevalier, S. A.; Duprez, R.; Afonso, P.; Froment, A.; Gessain, A.; Mahieux, R. (2006). "Human T-Cell Lymphotropic Virus Type 3: Complete Nucleotide Sequence and Characterization of the Human Tax3 Protein". Journal of Virology 80 (19): 9876–88. doi:10.1128/JVI.00799-06. PMC 1617244. PMID 16973592. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1617244/.
^ Mahieux, R.; Gessain, Antoine (2009). "The human HTLV-3 and HTLV-4 retroviruses: New members of the HTLV family". Pathologie Biologie 57 (2): 161–6. doi:10.1016/j.patbio.2008.02.015. PMID 18456423.
^ MURPHEY-CORB, MICHAEL; LOUIS N. MARTIN, S. R. S. RANGAN, GARY B. BASKIN, BOBBY J. GORMUS, ROBERT H. WOLF, W. ABE ANDES, MELANIE WEST & RONALD C. MONTELARO (22). "Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys". Nature 321 (321): 435 - 437. doi:10.1038/321435a0. http://www.nature.com/nature/journal/v321/n6068/abs/321435a0.html. Retrieved 10 May 2012.
^ Calattini, Sara; Betsem, Edouard; Bassot, Sylviane; Chevalier, SéBastien Alain; Mahieux, Renaud; Froment, Alain; Gessain, Antoine (2009). "New Strain of Human T Lymphotropic Virus (HTLV) Type 3 in a Pygmy from Cameroon with Peculiar HTLV Serologic Results". The Journal of Infectious Diseases 199 (4): 561–4. doi:10.1086/596206. PMID 19099485.
^ Chevalier, S. A.; Ko, N. L.; Calattini, S.; Mallet, A.; Prevost, M.-C.; Kehn, K.; Brady, J. N.; Kashanchi, F. et al. (2008). "Construction and Characterization of a Human T-Cell Lymphotropic Virus Type 3 Infectious Molecular Clone". Journal of Virology 82 (13): 6747–52. doi:10.1128/JVI.00247-08. PMC 2447071. PMID 18417569. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2447071/.
^ Human+T-Lymphotropic+Virus+Type+III at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Human+T+Lymphotropic+Virus+Type+IV at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Rodriguez, Evelyn M.; de Moya, E. Antonio; Guerrero, Ernesto; Monterroso, Edgar R.; Quinn, Thomas C.; Puello, Elizardo; de Quiñones, Margarita Rosado; Thorington, Bruce et al. (1993). "HIV-1 and HTLV-I in sexually transmitted disease clinics in the Dominican Republic". Journal of acquired immune deficiency syndromes 6 (3): 313–8. PMID 8450407. http://journals.lww.com/jaids/Abstract/1993/03000/HIV_1_and_HTLV_I_in_Sexually_Transmitted_Disease.18.aspx.
^ Roucoux, Diana F.; Wang, Baoguang; Smith, Donna; Nass, Catharie C.; Smith, James; Hutching, Sheila T.; Newman, Bruce; Lee, Tzong-Hae et al. (2005). "A Prospective Study of Sexual Transmission of Human T Lymphotropic Virus (HTLV)-I and HTLV-II". The Journal of Infectious Diseases 191 (9): 1490–7. doi:10.1086/429410. PMID 15809908.

External links

med/1038 at eMedicine - "human T-cell lymphotrophic virus"
International Retrovirology Association
Human+T-lymphotropic+virus+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
Human+T-lymphotropic+virus+2 at the US National Library of Medicine Medical Subject Headings (MeSH)
Human T-Cell Leukemia/Lymphoma Virus Type 1: Playing Hide and Seek

UpToDate Contents

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1. ヒトTリンパ球好性ウイルスI型：疾患関連、診断、および治療 human t lymphotropic virus type i disease associations diagnosis and treatment
2. ヒトTリンパ球好性ウイルスI型：ウイルス学、病因、および疫学 human t lymphotropic virus type i virology pathogenesis and epidemiology
3. HIV感染患者における薬剤抵抗性性器単純ヘルペスウイルス感染の治療 treatment of drug resistant genital herpes simplex virus infection in hiv infected patients
4. HIV感染患者における性器単純ヘルペスウイルスの疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of genital herpes simplex virus in hiv infected patients
5. 新生児における院内ウイルス感染症 nosocomial viral infections in the neonate

English Journal

Multiplex real-time PCR for the detection and quantitation of HTLV-1 and HTLV-2 proviral load: Addressing the issue of indeterminate HTLV results.

Waters A, Oliveira AL, Coughlan S, de Venecia C, Schor D, Leite AC, Araujo AQ, Hall WW.SourceNational Virus Reference Laboratory (NVRL), University College Dublin, Belfield, Dublin 4, Ireland.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.J Clin Virol.2011 Sep;52(1):38-44. Epub 2011 Jun 24.
BACKGROUND: Routine diagnosis of Human T Lymphotropic virus (HTLV) infection is primarily serologically based; however the proportion of unresolved and indeterminate Western blot results range from 0.02% to 50% in endemic areas.OBJECTIVES: To validate a sensitive in-house quantitative multiplex real
PMID 21704554

Human T Lymphotropic Virus Type 1 Regulatory and Accessory Gene Transcript Expression and Export Are Not Rex Dependent.

Li M, Kannian P, Yin H, Kesic M, Green PL.Source1 Center for Retrovirus Research, The Ohio State University , Columbus, Ohio.
AIDS research and human retroviruses.AIDS Res Hum Retroviruses.2011 Aug 5. [Epub ahead of print]
Abstract Human T lymphotropic virus type 1 (HTLV-1) requires regulated gene expression from unspliced and alternatively spliced transcripts for efficient replication and persistence. HTLV-1 Rex is known to facilitate cytoplasmic export of unspliced, gag/pol and incompletely spliced env mRNAs, but it
PMID 21819218

Japanese Journal

LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway.

Hasegawa H,Yamada Yasuaki,Tsukasaki Katsumi,Mori N,Tsuruda Kazuto,Sasaki Daisuke,Usui Tetsuya,Osaka Akemi,Atogami Sunao,Ishikawa Chie,Machijima Yoshiaki,Sawada S,Hayashi Tomayoshi,Miyazaki Yasushi,Kamihira Shimera
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 25(4), 575-578, 2011-04
… To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/Adult T-cell leukemia/lymphoma (ATLL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), is resistant to treatment. …
NAID 120002835134

Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines

Kai Hisahiro,Akamatsu Ena,Torii Eri [他]
Journal of natural medicines 65(3・4), 651-655, 2011
NAID 40018868047

Related Pictures

★リンクテーブル★

リンク元	「ヒトT細胞白血病ウイルス」「human T-cell leukemia virus」「ヒトTリンパ好性ウイルス」「ヒトTリンパ球好性ウイルス」
拡張検索	「human T-lymphotropic virus type 2」「human T-lymphotropic virus type 1」
関連記事	「human」「T」「virus」

「ヒトT細胞白血病ウイルス」

Human T-lymphotropic virus
Virus classification
Group:	Group VI (ssRNA-RT)
Family:	Retroviridae
Subfamily:	Orthoretrovirinae
Genus:	Deltaretrovirus
Species:	Simian T-lymphotropic virus
Serotypes
	Human T-lymphotropic virus

　　[★]

英: human T-lymphotropic virus, human T-cell leukemia virus, human T cell leukemia virus, HTLV
同: ヒトTリンパ球好性ウイルスヒトTリンパ好性ウイルス human T-lymphotropic virus、ヒトTリンパ球向性ウイルス
関

[show details]

ヒトTリンパ好性ウイルス : 約 29,900 件
ヒトTリンパ球向性ウイルス : 約 74,200 件
ヒトT細胞白血球ウイルス : 15 件
ヒトT細胞白血病ウイルス : 約 171,000 件

ウイルス学

レトロウイルス科デルタレトロウイルス属
エンベロープ有り
一本鎖+鎖RNA

種類

ヒトT細胞白血病ウイルス1型 HTLV-1

成人T細胞白血病（ATL）やHTLV-I関連脊髄症(HTLV-I-associated myelopathy；HAM)の原因

ヒトT細胞白血病ウイルス2型 HTLV-2
レトロウイルス科デルタレトロウイルス属
一本鎖RNA(+)ゲノムを2分子有する
コアがエンベロープで包まれている

感染症

1. 白血病/リンパ腫

成人T細胞白血病

2. 自己免疫病

痙性脊髄麻痺
HTLV関連ぶどう膜炎 HTLV associated uveitis

「human T-cell leukemia virus」

　　[★]

ヒトT細胞白血病ウイルス、ヒトTリンパ球向性ウイルス

関: deltaretrovirus、HTLV、human T-cell lymphotropic virus、human T-lymphotropic virus

「ヒトTリンパ好性ウイルス」

　　[★]

英: human T-lymphotropic virus
関: ヒトTリンパ球好性ウイルス、ヒトTリンパ球向性ウイルス

「ヒトTリンパ球好性ウイルス」

　　[★]

英: human T-lymphotropic virus
関: ヒトTリンパ球向性ウイルス、ヒトTリンパ好性ウイルス

「human T-lymphotropic virus type 2」

　　[★]

ヒトTリンパ球向性ウイルス2型、ヒトTリンパ好性ウイルス2型

関: HTLV-2、HTLV-II、human T-cell leukemia virus II、human T-cell leukemia virus type 2、human T-cell leukemia virus type II、human T-cell lymphotropic virus type 2、human T-lymphotropic virus 2、human T-lymphotropic virus type II