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Fresneau B1, Orbach D2, Faure-Conter C3, Verité C4, Castex MP5, Kalfa N6, Martelli H7, Patte C1.
Pediatric blood & cancer.Pediatr Blood Cancer.2015 Dec;62(12):2114-9. doi: 10.1002/pbc.25614. Epub 2015 Jul 23.
BACKGROUND: We present the results of the TGM-95 study for gonadal sex-cord stromal tumors (SCT).METHODS: Between 1995 and 2005, children (<18 years) with gonadal SCT were prospectively registered. Primary gonadal resection was recommended whenever feasible. Patients with disseminated disease or
PMID 26206391

Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature.

Burckhardt MA1, Udhane SS1, Marti N1, Schnyder I1, Tapia C1, Nielsen JE1, Mullis PE1, Rajpert-De Meyts E1, Flück CE2.
European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2015 Nov;173(5):K1-K12. doi: 10.1530/EJE-15-0599. Epub 2015 Aug 19.
CONTEXT: 3β-hydroxysteroid dehydrogenase deficiency (3βHSD) is a rare disorder of sexual development and steroidogenesis. There are two isozymes of 3βHSD, HSD3B1 and HSD3B2. Human mutations are known for the HSD3B2 gene which is expressed in the gonads and the adrenals. Little is known about test
PMID 26290012

The suppressive effect of immune stress on LH secretion is absent in the early neonatal period in rats.

Munkhzaya M1, Matsuzaki T1, Iwasa T1, Tungalagsuvd A1, Kawami T1, Kato T1, Kuwahara A1, Irahara M2.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2015 Nov;46:38-43. doi: 10.1016/j.ijdevneu.2015.06.007. Epub 2015 Jul 15.
Some physiological functions display weak responses to stress in the early neonatal period; i.e., they exhibit stress hyporesponse periods. In this study, we evaluated whether gonadotropin regulatory factors exhibit stress hyporesponsive periods in male and female rats. Rats were intraperitoneally i
PMID 26188106

大島純平,植村元秀,加藤大悟,永原啓,木内寛,辻村晃,野々村祝夫
泌尿器科紀要 = Acta urologica Japonica 60(4), 183-187, 2014-04
… We present a case study of a 46-year-old man with extra gonadal germ cell tumor with multiple lung metastases and very high levels (324, 100 mIU/ml) of the tumor marker human chorionic gonadotropin (hCG). … After salvage chemotherapies, levels of the tumor marker hCG decreased to normal levels, and retroperitoneal lymph node dissection and left lung wedge resection were performed to confirm pathological complete remission. …
NAID 120005439511

Tumors of Bilateral Streak Gonads in Patients with Disorders of Sex Development Containing Y Chromosome Material

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Clinical Pediatric Endocrinology 23(3), 93-97, 2014
… The aim of this study was to present our experience with prophylactic gonadectomy in those patients and evaluate their risk of gonadal tumors. … Pathologic examination revealed gonadal tumors in 6 of 11 patients (56%), including 4 with TS, the youngest of which was 2 yr old, one with Swyer syndrome and one with Frasier syndrome. …
NAID 130004677664