glucose-6-phosphate dehydrogenase deficiency

出典: meddic

グルコース-6-リン酸脱水素酵素欠損症

G6PD deficiency
G6PD

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/12 18:32:32」(JST)

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英文文献

  • Therapeutic potential of manipulating suicidal erythrocyte death.
  • Lang F1, Jilani K, Lang E.
  • Expert opinion on therapeutic targets.Expert Opin Ther Targets.2015 Sep;19(9):1219-27. doi: 10.1517/14728222.2015.1051306. Epub 2015 May 26.
  • INTRODUCTION: Eryptosis, the suicidal erythrocyte death, is characterized by erythrocyte shrinkage and phosphatidylserine translocation to the erythrocyte surface. Eryptosis is triggered by cell stress such as energy depletion and oxidative stress, by Ca(2+)-entry, ceramide, caspases, calpain and/or
  • PMID 26013571
  • Prevalence of glucose-6-phosphate dehydrogenase deficiency and diagnostic challenges in 1500 immigrants in Denmark examined for haemoglobinopathies.
  • Warny M1, Klausen TW, Petersen J, Birgens H.
  • Scandinavian journal of clinical and laboratory investigation.Scand J Clin Lab Invest.2015 Sep;75(5):390-7. doi: 10.3109/00365513.2015.1031692. Epub 2015 Apr 30.
  • Similar to the thalassaemia syndromes, glucose-6-phosphate dehydrogenase (G6PD) deficiency is highly prevalent in areas historically exposed to malaria. In the present study, we used quantitative and molecular methods to determine the prevalence of G6PD deficiency in a population of 1508 immigrants
  • PMID 25925739
  • Glucose-6-phosphate dehydrogenase deficiency among malaria patients of Honduras: a descriptive study of archival blood samples.
  • Zúñiga MÁ1, Mejía RE2, Sánchez AL3,4, Sosa-Ochoa WH5, Fontecha GA6.
  • Malaria journal.Malar J.2015 Aug 7;14:308. doi: 10.1186/s12936-015-0823-z.
  • BACKGROUND: The frequency of deficient variants of glucose-6-phosphate dehydrogenase (G6PDd) is particularly high in areas where malaria is endemic. The administration of antirelapse drugs, such as primaquine, has the potential to trigger an oxidative event in G6PD-deficient individuals. According t
  • PMID 26249834

和文文献

  • 智歯周囲炎から溶血発作を生じたG6PD異常症の1例
  • 五島 秀樹,清水 武,川原 理絵 [他]
  • 日本口腔外科学会雑誌 58(6), 376-380, 2012-06
  • NAID 40019370377
  • 自治医科大学医動物学教室で4年間(2007-2010)に経験した寄生虫・衛生動物関連症例の検討
  • 松岡 裕之,山本 大介,早川 枝李 [他],諏合 輝子,佐野 元市郎,平井 誠,吉田 栄人
  • 自治医科大学紀要 34, 117-128, 2012-03-01
  • … 新生児の溶血性貧血またはマラリアの治療に関連してglucose-6-phosphate dehydrogenase (G6PD)活性検査の依頼が34件寄せられた。 … 新生児に強い黄疸が生じ母親が外国人である場合,G6PD欠損症を疑って本酵素の活性を検査するべきである。 …
  • NAID 110008922665
  • ABO血液型不適合により重症黄疸に至ったグルコース6リン酸脱水素酵素異常症の1例
  • 土屋 浩史,徳永 康行
  • 日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology 21(1), "S-59"-"S-60", 2011-06-01
  • NAID 10029378143

関連リンク

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is a hereditary condition in which red blood cells break down when the body is exposed to certain ... Causes G6PD deficiency occurs when a person is missing ...
Glucose-6-Phosphate Dehydrogenase Deficiency Definition Glucose-6-phosphate dehydrogenase deficiency is an inherited condition caused by a defect or defects in the gene that codes for the enzyme, glucose-6-phosphate ...

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★リンクテーブル★
先読みG6PD deficiency
リンク元グルコース-6-リン酸脱水素酵素欠損症」「X連鎖劣性遺伝病」「ブドウ糖-6-リン酸脱水素酵素欠損症
関連記事deficiency」「phosphate」「glucose」「dehydrogenase」「dehydrogenases

G6PD deficiency」

  [★] グルコース-6-リン酸脱水素酵素欠損症


グルコース-6-リン酸脱水素酵素欠損症」

  [★]

glucose-6-phosphate dehydrogenase deficiency
G6PD欠損症 G6PD deficiencyグルコース-6-リン酸デヒドロゲナーゼ欠損症ブドウ糖-6-リン酸脱水素酵素欠損症glucose-6-phosphate dehydrogenase欠乏症G6PD欠乏症
ペントースリン酸経路グルコース6-リン酸脱水素酵素 G6PD血管内溶血溶血性貧血グルコース6-リン酸脱水素酵素



G6PD is a rate-limiting enzyme in HMP shunt (which yields NADPH). NADPH is necessary to keep glutathione reduced, which in turn detoxifies free radicals and peroxides. ↓ NADPH in RBCs leads to hemolytic anemia due to poor RBC defense against oxidizing agents (fava beans, sulfonamides, primaquine) and antituberculosis drugs.
People of Mediterranean descent can also have G6PD deficiency, but to a much greater degree. Therefore, hemolytic episodes inthe population are more severe(and can be fatal) as compared with those of the African American type, which are usually mild and felf-limited.
G6PD deficiency is more prevalent among blacks.
Heinz bodies..altered Hemoglobin precipitates within RBCs.
Increased malarial resistance.

概念

病因

疫学

遺伝形式

病変形成&病理

症状

診断

検査

治療

予後

予防

X連鎖劣性遺伝病」

  [★]

X-linked recessive disorder
伴性劣性遺伝病X連鎖遺伝病

X-linked recessive disorders (first aid step p.109)

Female carriers of X-linked recessive disorders are rarely affected because of random inactivation of X chromosomes in each cell.


ブドウ糖-6-リン酸脱水素酵素欠損症」

  [★]

glucose-6-phosphate dehydrogenase deficiency, G6PD deficiency


deficiency」

  [★]

  • n.
  • 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
  • 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの
absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve

PrepTutorEJDIC   license prepejdic

「〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥」


phosphate」

  [★]

  • n.
inorganic phosphateorthophosphateorthophosphoric acidphosphophosphoesterphosphoricphosphoric acidphosphoric acid esterphosphorus

WordNet   license wordnet

「a salt of phosphoric acid」
orthophosphate, inorganic phosphate

WordNet   license wordnet

「carbonated drink with fruit syrup and a little phosphoric acid」

PrepTutorEJDIC   license prepejdic

「〈U〉リン酸塩 / 《複数形で》リン酸肥料」


glucose」

  [★] グルコース

WordNet   license wordnet

「a monosaccharide sugar that has several forms; an important source of physiological energy」

PrepTutorEJDIC   license prepejdic

「ブドウ糖」


dehydrogenase」

  [★] 脱水素酵素 デヒドロゲナーゼ


dehydrogenases」

  [★] 脱水素酵素 デヒドロゲナーゼ




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