塩酸ジブカイン、ジブカイン塩酸塩

関: dibucaine

WordNet

a complex consisting of an organic base in association with hydrogen chloride
a local anesthetic that is administered by injection

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/18 18:25:40」(JST)

wiki en

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.^[1]^[2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Medical use[edit]

Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

Physical properties[edit]

Cinchocaine is relatively insoluble in alkaline aquatic solutions.

References[edit]

^ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
^ Dibucaine

UpToDate Contents

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English Journal

Interaction of local anesthetics with lipid bilayers investigated by (1)H MAS NMR spectroscopy.

Weizenmann N, Huster D, Scheidt HA.AbstractThe membrane location of the local anesthetics (LA) lidocaine, dibucaine, tetracaine, and procaine hydrochloride as well as their influence on phospholipid bilayers were studied by (31)P and (1)H magic-angle spinning (MAS) NMR spectroscopy. The (31)P NMR spectra of the LA/lipid preparations confirmed that the overall bilayer structure of the membrane remained preserved. The relation between the molecular structure of the LAs and their membrane localization and orientation was investigated quantitatively using induced chemical shifts, nuclear Overhauser enhancement spectroscopy, and paramagnetic relaxation rates. All three methods revealed an average location of the aromatic rings of all LAs in the lipid-water interface of the membrane, with small differences between the individual LAs depending on their molecular properties. While lidocaine is placed in the upper chain/glycerol region of the membrane, for dibucaine and procaine the maximum of the distribution are slightly shifted into the glycerol region. Finally for tetracaine the aromatic ring is placed closest to the aqueous phase in the glycerol/headgroup region of the membrane. The hydrophobic side chains of the LA molecules dibucaine and tetracaine were located deeper in the membrane and showed an orientation towards the hydrocarbon core. In contrast the side chains of lidocaine and procaine are oriented towards the aqueous phase.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 Jul 25;1818(12):3010-3018. [Epub ahead of print]
The membrane location of the local anesthetics (LA) lidocaine, dibucaine, tetracaine, and procaine hydrochloride as well as their influence on phospholipid bilayers were studied by (31)P and (1)H magic-angle spinning (MAS) NMR spectroscopy. The (31)P NMR spectra of the LA/lipid preparations confirme
PMID 22842001

Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic.

Yamadori Y, Oiso N, Hirao A, Kawara S, Kawada A.SourceDepartment of Dermatology, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka, Japan.
Contact dermatitis.Contact Dermatitis.2009 Jul;61(1):52-3.
PMID 19659969

Japanese Journal

リドカイン塩酸塩によるアナフィラキシーの1例

皮膚の科学 11(5), 409-412, 2012
NAID 130004546910

臨床腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果

整形・災害外科 51(11), 1477-1481, 2008-10
NAID 40016277446

ネオビタカイン^【○!R】の偶発的クモ膜下投与で長時間の麻痺を生じた2症例

The journal of the Japan Society of Pain Clinicians = 日本ペインクリニック学会誌 15(1), 35-37, 2008-01-25
NAID 10020158469

「ジブカイン」

Cinchocaine
Systematic (IUPAC) name
	2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Routes	topical, intravenous (equine euthanasia)
Identifiers
CAS number	85-79-0
ATC code	C05AD04 D04AB02 N01BB06 S01HA06 S02DA04
PubChem	CID 3025
DrugBank	DB00527
ChemSpider	2917
UNII	L6JW2TJG99
KEGG	D00733
ChEBI	CHEBI:247956
ChEMBL	CHEMBL1086
Chemical data
Formula	C20H29N3O2
Mol. mass	343.463 g/mol
	SMILES O=C(c1c2ccccc2nc(OCCCC)c1)NCCN(CC)CC;
	InChI InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) ; Key:PUFQVTATUTYEAL-UHFFFAOYSA-N ;
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　　[★]

英: dibucaine
化: ジブカイン塩酸塩, 塩酸ジブカイン, dibucaine hydrochloride
商: ペルカミンエス、ジカベリン、ジブカルソー、タイオゼット、トリガイン、ネオビタカイン、ネオペルカミン、ビーセルファ、プロクトセディル、プロネスパスタアロマ、ペリオドン、ペルカミン
関: シンコカイン、局所麻酔薬

「dibucaine hydrochloride and p-butylaminobenzoyl diethylaminoethyl hydrochloride mixture」

　　[★] 塩酸ジブカイン・塩酸パラブチルアミノ安息香酸ジエチルアミノエチル合剤

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

「dibucaine」

　　[★]

日
関

同: Nupercainal

[1] Martindale, The Extra Pharmacopoeia, 30th ed, p1006

[2] Dibucaine

リンク元	「ジブカイン」
拡張検索	「dibucaine hydrochloride and p-butylaminobenzoyl diethylaminoethyl hydrochloride mixture」
関連記事	「hydrochloride」「dibucaine」

匿名

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案内

案内

dibucaine hydrochloride