出典: meddic

  • n.
degeneracydegeneratedegenerativedenaturationdenatureinvolutionretractretrograde degenerationretrograde degradationunfolding

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「the process of declining from a higher to a lower level of effective power or vitality or essential quality」

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「passing from a more complex to a simpler biological form」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/05 14:04:29」(JST)

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  • Glycosaminoglycan measured from synovial fluid serves as a useful indicator for progression of Osteoarthritis and complements Kellgren-Lawrence Score.
  • Kulkarni P1, Deshpande S2, Koppikar S1, Patil S2, Ingale D1, Harsulkar A1.
  • BBA clinical.BBA Clin.2016 May 12;6:1-4. doi: 10.1016/j.bbacli.2016.05.002. eCollection 2016.
  • BACKGROUND: Plain radiography is the first choice for diagnosis and monitoring of knee-osteoarthritis (OA) while, Kellgren-Lawrence score (KL) is most widely used to grade OA severity. However, incompetency for reproducibility of joint space measurement in longitudinal assessment and non-linearity o
  • PMID 27331021
  • A new method to quantify tau pathologies with (11)C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter.
  • Kimura Y1, Endo H2,3, Ichise M4, Shimada H2, Seki C2, Ikoma Y2, Shinotoh H2, Yamada M2, Higuchi M2, Zhang MR2, Suhara T2.
  • EJNMMI research.EJNMMI Res.2016 Dec;6(1):24. doi: 10.1186/s13550-016-0182-y. Epub 2016 Mar 12.
  • BACKGROUND: Quantitative in vivo imaging of tau pathologies potentially improves diagnostic accuracy of neurodegenerative tauopathies and would facilitate evaluation of disease-modifying drugs targeting tau lesions in these diseases. Tau pathology can be quantified by reference tissue models without
  • PMID 26969002
  • Qualitative and quantitative measurement of the anterior and posterior meniscal root attachments of the New Zealand white rabbit.
  • Civitarese D1, Donahue TL2, LaPrade CM3, Saroki AJ4, Moulton SG5, Schon JM6, LaPrade RF7,8.
  • Journal of experimental orthopaedics.J Exp Orthop.2016 Dec;3(1):10. doi: 10.1186/s40634-016-0046-4. Epub 2016 Feb 29.
  • BACKGROUND: The purpose of this study was to quantify the meniscal root anatomy of the New Zealand white rabbit to better understand this animal model for future in vitro and in vivo joint degeneration studies.METHODS: Ten non-paired fresh frozen New Zealand white rabbit knee stifle joints were care
  • PMID 26928558
  • Joint sparing treatments in early ankle osteoarthritis: current procedures and future perspectives.
  • Castagnini F1, Pellegrini C2, Perazzo L2, Vannini F2, Buda R3.
  • Journal of experimental orthopaedics.J Exp Orthop.2016 Dec;3(1):3. doi: 10.1186/s40634-016-0038-4. Epub 2016 Jan 15.
  • Ankle osteoarthritis (AOA) is a severe pathology, mostly affecting a post-traumatic young population. Arthroscopic debridement, arthrodiastasis, osteotomy are the current joint sparing procedures, but, in the available studies, controversial results were achieved, with better outcomes in case of lim
  • PMID 26915003


  • 視細胞の再生医療 (眼疾患の再生治療)
  • 運動失調を伴う神経変性疾患のSTEFとBarthel indexの関連
  • 南雲 浩隆,前田 眞治
  • 作業療法 = Japanese occupationai therapy researh : JOTR 31(3), 267-277, 2012-06
  • NAID 40019313924
  • ラニビズマブ投与により網膜色素上皮障害が進行し視力低下をきたした1例 (特集 第65回日本臨床眼科学会講演集(3))
  • 佐藤 孝樹,家久来 啓吾,鈴木 浩之 [他]
  • 臨床眼科 66(5), 695-699, 2012-05
  • NAID 40019332267


The idea of degeneration goes back to the 18th century, and had significant influence on science, art and politics from the 1850s to the 1950s. The social theory developed consequently from Charles Darwin's Theory of Evolution. Evolution ...
degeneration. About Our Definitions: All forms of a word (noun, verb, etc.) are now displayed on one page. 3 ENTRIES FOUND: degeneration · degeneration disease · macular degeneration. de·gen·er·a·tion. noun \di-ˌje-nə-ˈrā-shən, ˌdē -\ ...
Synonyms for degeneration at with free online thesaurus, antonyms, and definitions. Dictionary and Word of the Day.



拡張検索retrograde degeneration」「leukodegeneration」「Bietti tapetoretinal degeneration」「subacute combined degeneration



  • n.

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「reduction in size of an organ or part (as in the return of the uterus to normal size after childbirth)」

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「the action of enfolding something」

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「a long and intricate and complicated grammatical construction」

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「巻き(包み)込むこと,巻き込まれた状態 / 複雑なもの,込み入ったもの」



degeneration, denaturation

組織学的な変性 degeneration

空砲変性 薬疹、皮膚科領域疾患
脂肪変性 脂肪肝、ネフローゼ症候群、筋脂肪変性
好酸性変性 ウイルス性肝炎、アルコール性肝炎
硝子様変性 小動脈硬化。HE染色で均質な好酸性。
フィブリノイド変性 膠原病、アレルギー。HE染色でやや光沢のある不均質な好酸性物質。
粘液変性 HE染色で不均質な淡い好塩基性物質として見える。

蛋白質の変性 denaturation



  • 変性させる

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「modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished」

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「add nonfissionable material to (fissionable material) so as to make unsuitable for use in an atomic bomb」

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「make (alcohol) unfit for drinking without impairing usefulness for other purposes」



  • adj.
  • 対価的な、退行性の。堕落させる。変性の

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「(of illness) marked by gradual deterioration of organs and cells along with loss of function; "degenerative diseases of old age"」

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  • v.
  • 縮退する, 縮める

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「use a surgical instrument to hold open (the edges of a wound or an organ)」
pull back, draw back

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「…‘を'引っ込ませる / 〈宣言・約束など〉‘を'撤回する,取り消す / 引っ込む,縮む / (約束などを)取り消す《+『from』+『名』》」

retrograde degeneration」



degenerationretrograde degradationtrans-synaptic degeneration


  [★] 白質ジストロフィー、白質変性症

Bietti tapetoretinal degeneration」

  [★] ビエッティジストロフィー

subacute combined degeneration」

  [★] 亜急性連合性脊髄変性症