chronic lymphoid leukemia

出典: meddic

慢性リンパ性白血病

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/31 12:18:02」(JST)

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英文文献

  • Dendrimer-based nanoparticles for potential personalized therapy in chronic lymphocytic leukemia: Targeting the BCR-signaling pathway.
  • Franiak-Pietryga I1, Maciejewski H2, Ostrowska K3, Appelhans D4, Voit B4, Misiewicz M5, Kowalczyk P6, Bryszewska M7, Borowiec M8.
  • International journal of biological macromolecules.Int J Biol Macromol.2016 Jul;88:156-61. doi: 10.1016/j.ijbiomac.2016.03.021. Epub 2016 Mar 14.
  • Chronic lymphocytic leukemia (CLL) is one of the most prevalent forms of leukemia in western society. Although classic chemoimmune therapy is still the gold standard of care for leukemic patients, effective therapy of CLL is yet to be achieved. The present study examines the influence of poly(propyl
  • PMID 26987432
  • Comment: In Response to "Downgraded Lymphoma: B-Chronic Lymphocytic Leukemia in a Known Case of Diffuse Large B-Cell Lymphoma - De Novo Occurrence or Transformation".
  • Uz B1, Acar K.
  • Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2016 Jun 5;33(2):164-165. doi: 10.4274/tjh.2015.0452. Epub 2016 Apr 18.
  • PMID 27094032
  • Chronic lymphocytic leukemia therapy: new targeted therapies on the way.
  • Vitale C1, Burger JA1.
  • Expert opinion on pharmacotherapy.Expert Opin Pharmacother.2016 Jun;17(8):1077-89. doi: 10.1517/14656566.2016.1168401. Epub 2016 Apr 12.
  • INTRODUCTION: The critical role of the tissue microenvironment and B-cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) pathogenesis, and the clinical success of targeted agents that disrupt BCR signaling are currently changing the CLL landscape. Three new drugs were recently approv
  • PMID 26988407

和文文献

  • リンパ系腫瘍幹細胞研究の最前線 (特集 リンパ性白血病診療の現状と展望)
  • 菊繁 吉謙,宮本 敏浩,赤司 浩一
  • 血液内科 66(2), 113-120, 2013-02
  • NAID 40019614019
  • リンパ系腫瘍における血清FLCの意義
  • Adult T cell Leukemia-Lymphoma
  • Tsukasaki Kunihiro
  • Hematology 17(1), S32-S35, 2012-04-01
  • … Subsequently, a novel RNA retrovirus, human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) was isolated from a cell line established from the leukemic cells of an ATL patient, and the finding of a clear association with ATL led to its inclusion among human carcinogenic pathogens. … The diversity in clinical features and prognosis of patients with this disease has led to its subtype-classification into four categories, acute, lymphoma, chronic, and smoldering types defined by organ involvement, and LDH and calcium values. …
  • NAID 120004418955

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★リンクテーブル★
リンク元慢性リンパ性白血病
関連記事chronic」「leukemia」「lymphoid」「lymphoid leukemia

慢性リンパ性白血病」

  [★]

chronic lymphocytic leukemia, chronic lymphoid leukemia, CLL
白血病
  • first aid step1 2006 p.300,302,303,304,309,310,427,430

概念

  • the accumulation of nonproliferating mature-appearing lymphocytes in the blood, marrow, lymph nodes, and spleen.
  • monoclonal B lymphocytes.
  • CD5+ and CD23+CD5, CD23
  • derived from memory B cell.

細胞表面マーカー WCH.2438

condition smIg CD5 CD10 CD11c CD19 CD20 CD22 CD23 CD25 CD43 CD79b CD103 FMC7
chronic lymphocytic leukemia Dim ++ -/+ ++ Dim -/+ ++ +/- -/+
Waldenstrom macroglobulinemia ++ -/+ ++ ++ -/+ +/-
prolymphocytic leukemia +++ -/+ -/+ -/+ ++ +++ ++ ++ -/+ ++
hairy cell leukemia +++ ++ +++ +++ +++ +++ +++ +++
hairy cell leukemia variant +++ ++ +++ +++ +++ +++ +++
splenic lymphoma with villous lymphocytes ++ -/+ -/+ +/- ++ ++ ++ +/- -/+ ++ -/+ ++
marginal zone B-cell lymphoma ++ +/- ++ ++ +/- +/- -/+ ++
mantle cell lymphoma ++ ++ -/+ ++ ++ ++ ++ ++
follicular lymphoma ++ -/+ ++ ++ ++ ++ -/+ ++ ++

臨床像

HIM.693
  年齢 子供における頻度 男性(%) ステージI,II vs III,IV(%) B症状(%) 骨髄浸潤(%) 消化管浸潤(%) 5年生存率(%)
B細胞CLL/小リンパ球性リンパ腫 65 まれ 53 9 vs 91 33 72 3 51

疫学

YN.G-49
  • 全白血病の2-3%
  • 60歳以上に多い。
  • 男女比=2:1

病態

YN.G-49
  • 正常な免疫グロブリンの産生が抑制されるばかりでなく、異常な自己抗体を産生 → 続発性免疫不全症、自己免疫性溶血性貧血


USMLE

  • Q book p.246 42

参考

  • 1. [charged] Epidemiology and clinical manifestations of chronic lymphocytic leukemia - uptodate [1]
  • 2. [charged] Pathologic features, diagnosis, and differential diagnosis of chronic lymphocytic leukemia - uptodate [2]
  • 3. [charged] Pathophysiology and cytogenetics of chronic lymphocytic leukemia - uptodate [3]



[show details]


chronic」

  [★]

  • adj.
  • 慢性の、慢性的な、慢性型の
chronicallychronicity

WordNet   license wordnet

「being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"」

PrepTutorEJDIC   license prepejdic

「(病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった」

WordNet   license wordnet

「of long duration; "chronic money problems"」
continuing

WordNet   license wordnet

「habitual; "a chronic smoker"」
inveterate

leukemia」

  [★] 白血病

WordNet   license wordnet

「malignant neoplasm of blood-forming tissues; characterized by abnormal proliferation of leukocytes; one of the four major types of cancer」
leukaemia, leucaemia, cancer of the blood

PrepTutorEJDIC   license prepejdic

「白血病」


lymphoid」

  [★]

  • adj.
lymphatic system

WordNet   license wordnet

「resembling lymph or lymphatic tissues」

PrepTutorEJDIC   license prepejdic

「リンパ状(液)の」


lymphoid leukemia」

  [★]

リンパ性白血病リンパ様白血病

lymphoblastic leukemialymphocytic leukaemialymphocytic leukemia




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