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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/16 14:29:24」(JST)

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  • The progressive onset of cholinergic and adrenergic control of heart rate during development in the green iguana, Iguana iguana.
  • Sartori MR1, Leite CA2, Abe AS1, Crossley DA 2nd3, Taylor EW4.
  • Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2015 Oct;188:1-8. doi: 10.1016/j.cbpa.2015.06.003. Epub 2015 Jun 11.
  • The autonomic control of heart rate was studied throughout development in embryos of the green iguana, Iguana iguana by applying receptor agonists and antagonists of the parasympathetic and sympathetic systems. Acetylcholine (Ach) slowed or stopped the heart and atropine antagonized the response to
  • PMID 26071949
  • Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats.
  • Kurowski P1, Gawlak M1, Szulczyk P2.
  • Neuroscience.Neuroscience.2015 Sep 10;303:474-88. doi: 10.1016/j.neuroscience.2015.07.023. Epub 2015 Jul 14.
  • Damage to the cholinergic input to the prefrontal cortex has been implicated in neuropsychiatric disorders. Cholinergic endings release acetylcholine, which activates nicotinic and/or G-protein-coupled muscarinic receptors. Muscarinic receptors activate transduction systems, which control cellular e
  • PMID 26186898
  • Muscarinic and nicotinic cholinergic receptor antagonists differentially mediate acquisition of fructose-conditioned flavor preference and quinine-conditioned flavor avoidance in rats.
  • Rotella FM1, Olsson K2, Vig V2, Yenko I2, Pagirsky J2, Kohen I2, Aminov A2, Dindyal T2, Bodnar RJ3.
  • Neurobiology of learning and memory.Neurobiol Learn Mem.2015 Sep;123:239-49. doi: 10.1016/j.nlm.2015.07.004. Epub 2015 Jul 16.
  • Rats display both conditioned flavor preference (CFP) for fructose, and conditioned flavor avoidance (CFA) following sweet adulteration with quinine. Previous pharmacological analyses revealed that fructose-CFP expression was significantly reduced by dopamine (DA) D1 or D2 antagonists, but not NMDA
  • PMID 26188277


  • 舌がん患者の流涎にスコポラミン軟膏が有効であった1例
  • 三浦 篤史,篠原 佳祐,山本 亮,大塚 菜美,宮田 佳典,崎山 隼人
  • Palliative Care Research 10(2), 301-304, 2015
  • 舌がんでは,腫瘍増大による嚥下機能低下から流涎を招き,Quality of Life を低下させることがある.一般的に流涎の対応として,水分摂取量の減量,抗コリン薬の投与などが行われるが,充分に流涎を抑制できない場合がある.今回,ブチルスコポラミン臭化物の持続静注では流涎の改善が認められなかった舌がん患者に対して,院内製剤であるスコポラミン軟膏を耳介後部の乳様突起付近に貼付したところ流涎の緩和が認 …
  • NAID 130005085472
  • 泌尿器科疾患に対する薬の使い方 (特集 リハビリテーション医に必要な薬の上手な使い方)
  • 小川 由英,香野 友帆
  • Monthly book medical rehabilitation (178), 63-68, 2014-12
  • NAID 40020321903
  • Yokukansan: A Treatment Option for Nocturnal Enuresis in Children by Improving Sleep Quality
  • 順天堂醫事雑誌 60(6), 536-542, 2014
  • … it is effective for 65-70% of patients with NE.For patients who do not respond to desmopressin or an enuresis alarm, anticholinergics or tricyclic antidepressants are used; …
  • NAID 130005075345


Anticholinergics are a class of drugs that block the action of the neurotransmitter acetylcholine in the brain. They block involuntary movements of the muscles associated with diseases such as asthma, incontinence, gastrointestinal ...
Clinical Use The actual scientific literature regarding the use of anticholinergics in PD is limited. Techniques used to study tremor and other symptoms, the type of anticholinergic that was used, daily dose, duration of treatment, and ...



リンク元抗コリン薬」「muscarinic antagonist」「cholinolytic



anticholinergics, anticholinergic, anticholinergic agent, anticholinergic drug, cholinolytic, cholinolytic drug, cholinergic antagonist
抗コリン剤抗コリン作用薬コリン作用遮断薬 cholinergic blocking agent
ムスカリン性受容体拮抗薬 muscarinic antagonist

  • 副交感神経ムスカリン受容体拮抗薬であり、副交感神経作用を抑制する。


(YN2010 抗コリン薬(神経精神))
  • 1. 散瞳作用:眼底検査や虹彩炎治療など
  • 2. 膀胱利尿筋弛緩作用:尿路結石症鎮痙
  • 3. 腺分泌抑制作用:麻酔前投与
  • 4. 胃酸分泌抑制作用:抗胃潰瘍
  • 5. 消化管運動抑制作用
  • 6. 抗Parkinson作用
  • 7. 抗迷走神経作用:徐脈性不整脈の治療
  • 8. 農薬解毒作用:有機リン剤、カーバメート剤の解毒

therapeutic uses of muscarinic receptor antagonists

  • 呼吸器:気道分泌抑制。(アトロピンは気道分泌を抑制し、分泌物が乾固しうるが、イプラトロピウム、チオトロピウムはmucociliary clearanceにおける副作用を呈しないので、気道疾患に用いられている)
  • 泌尿器:過活動性膀胱、夜尿症、対麻痺における頻尿
  • 消化器:抗潰瘍薬(M1受容体選択性のある薬剤。ピレンゼピンテレンゼピン)。鎮痙薬

muscarinic antagonist」


anticholinergicanticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolyticcholinolytic drugmuscarinic receptor antagonist



  • adj.
  • 抗コリンの
  • n.
anticholinergicanticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolytic drugmuscarinic antagonist



  • adj.
  • 抗コリンの、抗コリン作用の、抗コリン性の
  • n.
anticholinergic agentanticholinergic druganticholinergicscholinergic antagonistcholinolyticcholinolytic drugmuscarinic antagonist

WordNet   license wordnet

「a substance that opposes or blocks the action of acetylcholine」
anticholinergic drug

WordNet   license wordnet

「inhibiting or blocking the action of acetylcholine at a receptor site; "anticholinergic drugs"」