amyloid precursor protein

出典: meddic

アミロイド前駆体蛋白質 APP

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/13 20:04:14」(JST)

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英文文献

  • Expression pattern of a single transgene cassette located in endogenous GLIS3 of cloned pigs; a nested situation.
  • Jakobsen JE, Dantoft TM, Johansen MG, Jørgensen AL.AbstractOne of the main focus areas in transgenesis is the choice of a promoter driving stable expression over time of the gene of interest. Besides promoter identity, the genomic environment of the transgene plays a pivotal role in transcription regulation. Studies in higher mammals describing transgene expression from a defined locus are very limited. We set out to determine the expression pattern of two transgene promoters, the human PDGFβ and the viral SV40, in a single cassette positioned in the largest intron of the porcine GLIS3 locus. The PDGFβ promoter drives a variant of the amyloid precursor protein gene named APP695sw and the SV40 promoter drives the neomycin resistant gene, Neo. The nested gene scenario was investigated in three transgenic cloned pigs sacrificed at 3months, 2years and 3years of age. With identical genetic make-up and same environment, the three individual pigs are considered representative of 3year lifespan of a single pig. Selected organs from the pigs were analyzed by quantitative RT-PCR for transgene promoter activity as well as endogenous GLIS3 promoter activity. No apparent effect of the transgene cassette was observed on endogenous GLIS3 expression. In addition, one year old homozygous pigs showed no phenotypic signs of dysfunctional GLIS3. Both transgene promoters showed and retained their tissue specificity with stable expression over time. Our study indicates that transgenes inserted in a nested situation might be applicable for faithful and long term transgene expression.
  • Gene.Gene.2012 Jul 10;502(2):94-8. Epub 2012 Apr 25.
  • One of the main focus areas in transgenesis is the choice of a promoter driving stable expression over time of the gene of interest. Besides promoter identity, the genomic environment of the transgene plays a pivotal role in transcription regulation. Studies in higher mammals describing transgene ex
  • PMID 22555020
  • Genetic testing in familial and young-onset Alzheimer's disease: mutation spectrum in a Serbian cohort.
  • Dobricic V, Stefanova E, Jankovic M, Gurunlian N, Novakovic I, Hardy J, Kostic V, Guerreiro R.SourceInstitute of Neurology, Clinical Center of Serbia, Belgrade, Serbia.
  • Neurobiology of aging.Neurobiol Aging.2012 Jul;33(7):1481.e7-1481.e12. Epub 2012 Jan 4.
  • Alzheimer's disease (AD) is the most common form of dementia. To date, more than 200 mutations in three genes have been identified as cause of early-onset autosomal dominant inherited AD. The aim of this study was to characterize the mutation spectrum and describe genotype-phenotype correlations in
  • PMID 22221884

和文文献

  • Continuation of Exercise Is Necessary to Inhibit High Fat Diet-Induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic Mice.
  • Maesako Masato,Uemura Kengo,Iwata Ayana,Kubota Masakazu,Watanabe Kiwamu,Uemura Maiko,Noda Yasuha,Asada-Utsugi Megumi,Kihara Takeshi,Takahashi Ryosuke,Shimohama Shun,Kinoshita Ayae
  • PloS one 8(9), 2013-09-04
  • … It has been previously reported that HFD clearly worsens cognitive function in amyloid precursor protein (APP) transgenic mice. … On the other hand, we have demonstrated that voluntary exercise in an enriched environment is an effective intervention to rescue HFD-induced β-amyloid (Aβ) deposition and memory deficit. …
  • NAID 120005324901
  • Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
  • Kondo Takayuki,Asai Masashi,Tsukita Kayoko,Kutoku Yumiko,Ohsawa Yutaka,Sunada Yoshihide,Imamura Keiko,Egawa Naohiro,Yahata Naoki,Okita Keisuke,Takahashi Kazutoshi,Asaka Isao,Aoi Takashi,Watanabe Akira,Watanabe Kaori,Kadoya Chie,Nakano Rie,Watanabe Dai,Maruyama Kei,Hori Osamu,Hibino Satoshi,Choshi Tominari,Nakahata Tatsutoshi,Hioki Hiroyuki,Kaneko Takeshi,Naitoh Motoko,Yoshikawa Katsuhiro,Yamawaki Satoko,Suzuki Shigehiko,Hata Ryuji,Ueno Shu-ichi,Seki Tsuneyoshi,Kobayashi Kazuhiro,Toda Tatsushi,Murakami Kazuma,Irie Kazuhiro,Klein William L.,Mori Hiroshi,Asada Takashi,Takahashi Ryosuke,Iwata Nobuhisa,Yamanaka Shinya,Inoue Haruhisa
  • Cell Stem Cell 12(4), 487-496, 2013-04-04
  • … Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. … Aβ oligomers accumulated in iPSC-derived neurons and astrocytes in cells from patients with a familial amyloid precursor protein (APP)-E693Δ mutation and sporadic AD, leading to endoplasmic reticulum (ER) and oxidative stress. …
  • NAID 120005231417
  • Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease
  • Yan Ji-Jing,Jung Jun-Sub,Kim Taek-Keun [他]
  • Biological & pharmaceutical bulletin 36(1), 140-143, 2013-01-00
  • NAID 40019536220

関連リンク

Amyloid precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, ...
ジキルとハイドのように、一見無害なものが有害なものに変わってしまう、そんな蛋白質 がある。アミロイドβ前駆体蛋白質(amyloid-beta precursor protein)は重要な事例の 一つである。これは大きな膜蛋白質で、通常は神経の成長と修復に欠かせない役割を ...

関連画像

Amyloid Precursor Protein SecretasesAmyloid precursor protein (APP) is by γ- secretase cleavage.Proteases, amyloid precursor protein amyloid precursor protein by called figure 1 the amyloid precursor protein app


★リンクテーブル★
リンク元アミロイド前駆体蛋白質」「APP」「アミロイド前駆体タンパク
拡張検索amyloid precursor protein secretase」「amyloid precursor protein gene」「amyloid precursor proteins
関連記事precursor」「protein」「amyloid」「precursor protein」「amyloid precursor

アミロイド前駆体蛋白質」

  [★]

amyloid precursor protein, amyloid precursor proteins, APP
アミロイドβ蛋白質前駆体 amyloid β-protein precursor β-APP
[show details]



APP」

  [★]


アミロイド前駆体タンパク」

  [★]

amyloid precursor protein
アミロイド前駆タンパク質、アミロイド前駆体タンパク質


amyloid precursor protein secretase」

  [★]

アミロイド前駆タンパク質セクレターゼアミロイド前駆タンパク質分泌酵素

alpha-secretasebeta-secretasegamma-secretasesecretase

amyloid precursor protein gene」

  [★] アミロイド前駆体蛋白質遺伝子

amyloid precursor proteins」

  [★] アミロイド前駆体蛋白質


precursor」

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  • n.
progenitor

WordNet   license wordnet

「a substance from which another substance is formed (especially by a metabolic reaction)」

WordNet   license wordnet

「a person who goes before or announces the coming of another」
forerunner

PrepTutorEJDIC   license prepejdic

「(…の)前朕,前触れ《+『of』+『名』》」

protein」

  [★] 蛋白質

WordNet   license wordnet

「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

PrepTutorEJDIC   license prepejdic

「蛋白(たんばく)質」


amyloid」

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アミロイド

amyloid fibrilamyloid protein

WordNet   license wordnet

「(pathology) a waxy translucent complex protein resembling starch that results from degeneration of tissue」

WordNet   license wordnet

「a non-nitrogenous food substance consisting chiefly of starch; any substance resembling starch」

precursor protein」

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amyloid precursor」

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