活性化誘導シチジンデアミナーゼ AID
WordNet
- reason or establish by induction
- cause to arise; "induce a crisis" (同)bring_on
- produce electric current by electrostatic or magnetic processes (同)induct
- cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
- cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
- making active and effective (as a bomb)
- stimulation of activity in an organism or chemical
- brought about or caused; not spontaneous; "a case of steroid-induced weakness"
PrepTutorEJDIC
- artificial insemination by donor 非配偶者間人工受精
- 〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
- 活動化 / (物質の)活性化(化学反応を起こしやすくすること)
UpToDate Contents
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English Journal
- Multiple clonal MLL fusions in a patient receiving CHOP-based chemotherapy.
- Shih SJ, Fass J, Buffalo V, Lin D, Singh SP, Diaz MO, Vaughan AT.SourceDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.
- British journal of haematology.Br J Haematol.2012 Oct;159(1):50-7. doi: 10.1111/j.1365-2141.2012.09248.x. Epub 2012 Jul 30.
- MLL rearrangements were analysed in the blood of a patient receiving chemotherapy for diffuse large B-cell lymphoma using inverse polymerase chain reaction targeting exon 12, parallel sequencing and a custom algorithm design. Of thirteen MLL rearrangements detected, five were capable of generating M
- PMID 22845170
- Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 mice.
- Bombardieri M, Barone F, Lucchesi D, Nayar S, van den Berg WB, Proctor G, Buckley CD, Pitzalis C.SourceCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom;
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Oct 1;189(7):3767-76. Epub 2012 Aug 31.
- Salivary glands in patients with Sjögren's syndrome (SS) develop ectopic lymphoid structures (ELS) characterized by B/T cell compartmentalization, the formation of high endothelial venules, follicular dendritic cell networks, functional B cell activation with expression of activation-induced cytidi
- PMID 22942425
Japanese Journal
- Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
- Kato Lucia,Begum Nasim A,Burroughs A Maxwell,Doi Tomomitsu,Kawai Jun,Daub Carsten O,Kawaguchi Takahisa,Matsuda Fumihiko,Hayashizaki Yoshihide,Honjo Tasuku
- Proceedings of the National Academy of Sciences of the United States of America 109(7), 2479-2484, 2012-02-14
- … Activation-induced cytidine deaminase (AID) is required for both somatic hypermutation and class-switch recombination in activated B cells. … To identify as-yet-unknown AID targets, we screened early AID-induced DNA breaks by using two independent genome-wide approaches. …
- NAID 120003988300
- Activation-Induced Cytidine Deaminase Expression in CD4(+)T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age.
- Qin Hongyan,Suzuki Keiichiro,Nakata Mikiyo,Chikuma Shunsuke,Izumi Nakako,Thi Huong Le,Maruya Mikako,Fagarasan Sidonia,Busslinger Meinrad,Honjo Tasuku,Nagaoka Hitoshi
- PloS one 6(12), 2011-12
- … Activation-induced cytidine deaminase (AID), produced by the Aicda gene, is essential for the immunoglobulin gene (Ig) alterations that form immune memory. …
- NAID 120003726138
Related Links
- AID(エーアイディー、エイド). [編集] 頭字語. AID (Artificial Insemination by Donor, 非 配偶者間人工授精) については、人工授精#ヒトにおける適用参照。 The Japanese Association for Infectious Diseases >> 日本感染症学会; AID (en:Activation- Induced ...
- 我々は1978年に、クラススイッチが遺伝子断片の欠失をともなうゲノム変換であること を提唱し、これを証明した。2000年には、クラススイッチと体細胞突然変異をゲノムに 刻む分子がactivation-induced cytidine deaminase (AID)であることを発見した。
Related Pictures
★リンクテーブル★
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- 英
- hyper-IgM syndrome HIMS, hyper-IgM syndrome HIGM
- 同
- IgM増加を伴う抗体欠乏症
原因遺伝子
- avtivation-induced cytosine deaminase
- RNA editing enzyme
概念
病型
- 高IgM症候群1型 HIGM1
- 高IgM症候群2型 HIGM2
- 高IgM症候群3型 HIGM3
遺伝
- 多くの場合。男児のみ。
- 遺伝子座:Xq28
病因
- 免疫グロブリンのクラススイッチ機構の異常→IgM産生可能。IgG、IgA、IgE産生不可
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- 活性化T細胞上のCD40リガンド(CD154)の遺伝子異常→CD40シグナルを介したB細胞のクラススイッチがおきない
疫学
症状
- XLAと同じく化膿菌の易感染性
- 細胞性免疫不全によるカリニ肺炎の発症
診断
- 血清免疫グロブリン値の検査値
- X連鎖劣性遺伝のものでは、活性化T細胞のCD154分子の有無をフローサイトメトリーで分析
- 確定診断:CD154またはAID遺伝子解析
検査
- 血清IgMは正常または高値
- 血清IgG、IgA、IgEは低値
- 一部の症例では好中球減少
治療
- 免疫グロブリン置換療法
- カリニ肺炎の治療・予防→ST合剤の内服
- 造血幹細胞移植
予後
予防
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- 英
- activation-induced cytidine deaminase AID
[show details]
活性化誘導シチジン脱アミノ酵素 : 34 件
活性化誘導性シチジン脱アミノ酵素 : 5 件
活性化誘導シチジンデアミナーゼ : 89 件
活性化誘導性シチジンデアミナーゼ : 31 件
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- 同
- activation-induced cytidine deaminase
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- 同
- activation-induced cytidine deaminase
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- 誘発する、誘導する、誘起する、導入する、引き起こす
- 関
- cause、challenge、derivation、elicit、elicitation、evocation、evoke、guidance、induction、inductive、introduce、introduction、precipitate、provocation、provoke、spark
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- hypercalcaemia induced pancreatitis 高カルシウム血症による膵炎
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- 関
- activate、activated、turn on
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デアミナーゼ、脱アミノ酵素