Src-family tyrosine kinase

Srcファミリーチロシンキナーゼ

WordNet

1. people descended from a common ancestor; "his family has lived in Massachusetts since the Mayflower" (同)family line, folk, kinfolk, kinsfolk, sept, phratry
2. primary social group; parents and children; "he wanted to have a good job before starting a family" (同)family unit
3. an association of people who share common beliefs or activities; "the message was addressed not just to employees but to every member of the company family"; "the church welcomed new members into its fellowship" (同)fellowship
4. a social unit living together; "he moved his family to Virginia"; "It was a good Christian household"; "I waited until the whole house was asleep"; "the teacher asked how many people made up his home" (同)household, house, home, menage
5. (biology) a taxonomic group containing one or more genera; "sharks belong to the fish family"
6. the 19th letter of the Roman alphabet (同)s
7. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
8. an amino acid found in most proteins; a precursor of several hormones

PrepTutorEJDIC

1. 《集合的に》『家族』,家庭 / 〈U〉《時にa family》(一家の)子供たち / 〈C〉(血縁に関係ある)『親族』,身内,一族,一門 / 〈U〉『家柄』;(特に)名門 / 〈C〉(関係ある人・物の)一団,一群,(生物分類の)科《+『of』+『名』》
2. sulfurの化学記号 / {略}South[ern]
3. strontiumの化学記号

UpToDate Contents

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• 1. 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の臨床使用 clinical use of tyrosine kinase inhibitors for chronic myeloid leukemia
• 2. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
• 3. 進行消化管間質腫瘍に対するチロシンキナーゼ阻害剤療法 tyrosine kinase inhibitor therapy for advanced gastrointestinal stromal tumors
• 4. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
• 5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia

English Journal

• Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through β-sheet formation.

• Wybenga-Groot LE, McGlade CJ.SourceThe Arthur and Sonia Labatt Brain Tumour Research Centre and Program in Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. Electronic address: leanne.wybenga.groot@utoronto.ca.
• Cellular signalling.Cell Signal.2013 Dec;25(12):2702-8. doi: 10.1016/j.cellsig.2013.08.040. Epub 2013 Sep 7.
• The Src-like adaptor proteins (SLAP/SLAP2) are key components of Cbl-dependent downregulation of antigen receptor, cytokine receptor, and receptor tyrosine kinase signaling in hematopoietic cells. SLAP and SLAP2 consist of adjacent SH3 and SH2 domains that are most similar in sequence to Src family
• PMID 24018043

• A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

• Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR.SourceCell Biology Program, The Hospital for Sick Children, TMDT East Tower #12-314, 101 College St., Toronto, Ontario, M5G 1L7; Canada. dkaplan@sickkids.ca.
• Current drug discovery technologies.Curr Drug Discov Technol.2013 Dec;10(4):283-304.
• Mass spectrometry-based technologies are increasingly utilized in drug discovery. Phosphoproteomics in particular has allowed for the efficient surveying of phosphotyrosine signaling pathways involved in various diseases states, most prominently in cancer. We describe a phosphotyrosine-based proteom
• PMID 23701117

• Phosphorylation and externalization of galectin-4 is controlled by Src family kinases.

• Ideo H, Hoshi I, Yamashita K, Sakamoto M.SourceLaboratory of Glycobiology, Noguchi Institute.
• Glycobiology.Glycobiology.2013 Dec;23(12):1452-62. doi: 10.1093/glycob/cwt073. Epub 2013 Sep 6.
• Galectin-4 is a cytosolic protein that lacks a signal sequence but is externalized and binds to 3-O-sulfated glycoconjugates extracellularly. The mechanism of subcellular localization and externalization of galectin-4 has not yet been determined. A preliminary experiment using pervanadate (PV) showe
• PMID 24013903

Japanese Journal

• Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

• Nabekura Tsukasa,Kanaya Minoru,Shibuya Akira,Fu Guo,Gascoigne Nicholas R.J.,Lanier Lewis L.
• Immunity 40(2), 225-234, 2014-02
• … Src-family tyrosine kinase Fyn and serine-threonine protein kinase C isoform eta (PKCη) signaling through DNAM-1 played distinct roles in the generation of MCMV-specific effector and memory NK cells. …
• NAID 120005425984

• Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation

• Mita Mitsuo,Tanaka Hitoshi,Yanagihara Hayato,Nakagawa Jun-ichi,Hishinuma Shigeru,Sutherland Cindy,Walsh Michael P.,Shoji Masaru
• Journal of Smooth Muscle Research 49(0), 26-45, 2013
• … Rho-associated kinase (ROK) activation plays an important role in K+-induced contraction of rat caudal arterial smooth muscle (Mita et al., Biochem J. … The present study investigated a potential role for tyrosine kinase activity in K+-induced RhoA activation and contraction. …
• NAID 130004922368

• Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase

• Okamura Toshimitsu,Kikuchi Tatsuya,Nodaira Mika [他],Odaka Kenichi,Fukushi Kiyoshi,Irie Toshiaki
• Biological and Pharmaceutical Bulletin 35(3), 433-437, 2012
• … Phosphorylation of tyrosine residues by protein tyrosine kinases (PTK) and phosphotyrosine/Src homology 2 (SH2) domain interactions are crucial not only for signal transduction but also for regulation of PTK activity. … Tyrosine residues also receive nitration and halogenation under oxidative conditions. …
• NAID 130001872328

Related Links

• Tyrosine kinaseとは - goo Wikipedia (ウィキペディア)

Src family tyrosine kinases are closely related, but demonstrate a wide variety of functionality. Roles or expressions of Src family tyrosine kinases vary significantly according to cell type, as well as during cell growth and ...

• Src Tyrosine Kinase

C. L. Abram and S. A. Courtneidge (2000) Src Family Tyrosine Kinases and Growth Factor Signaling. Experimental Cell Research 254, 1-13. Src Tyrosine Kinase - annotation of the Src protein and its family relationshipsInterPro. ...

• Src Proto-oncogene Tyrosine-protein Kinase Src

PP2 is Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM, ~100-fold less ... Tags: Src activation | Src kinase family | Src family kinases | Src activity | Src cancer | Src tyrosine kinase | Src pathway | Src ...

Related Pictures

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★リンクテーブル★

リンク元	「Srcファミリーチロシンキナーゼ」「Src-family kinase」「Src protein-tyrosine kinase」「Src tyrosine kinase」「Src kinase」
関連記事	「kinase」「S」「family」「Sr」

「Srcファミリーチロシンキナーゼ」

　　[★]

英

Src-family tyrosine kinase

関

Srcファミリー、SH1、SH2、SH3

• 受容体型チロシンキナーゼ
• SH1ドメイン, SH2ドメイン, SH3ドメインを持つ (IMM.831)
• SH1ドメイン：チロシンキナーゼの活性部位
• SH2ドメイン：リン酸化チロシン残基が結合できるドメイン
• SH3ドメイン：他のタンパク質のプロリンリッチな領域と相互作用する

「Src-family kinase」

　　[★]

Srcファミリーキナーゼ

関

SFK、Src kinase、Src protein-tyrosine kinase、Src tyrosine kinase、Src-family tyrosine kinase

「Src protein-tyrosine kinase」

　　[★]

• Srcタンパク質チロシンキナーゼ

関

Src kinase、Src tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

「Src tyrosine kinase」

　　[★]

• Srcチロシンキナーゼ

関

Src kinase、Src protein-tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

「Src kinase」

　　[★]

Srcキナーゼ

関

Src protein-tyrosine kinase、Src tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「S」

　　[★]

• セリン serine
• 胸骨上縁

　 　

「family」

　　[★]

• n.

• (生物)科

　 　 　 　 　 　

「Sr」

　　[★] ストロンチウム strontium