Src protein-tyrosine kinase

• Srcタンパク質チロシンキナーゼ

関

Src kinase、Src tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

WordNet

1. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
2. the 19th letter of the Roman alphabet (同)s
3. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
4. an amino acid found in most proteins; a precursor of several hormones

PrepTutorEJDIC

1. 蛋白(たんばく)質
2. sulfurの化学記号 / {略}South[ern]
3. strontiumの化学記号

UpToDate Contents

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• 1. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
• 2. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
• 3. 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の臨床使用 clinical use of tyrosine kinase inhibitors for chronic myeloid leukemia
• 4. T細胞受容体シグナル伝達 t cell receptor signaling
• 5. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations

English Journal

• Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway.

• Guo Y, Shan Q, Gong Y, Lin J, Yang X, Zhou R.SourceDepartment of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China.
• Cancer biology & therapy.Cancer Biol Ther.2012 Nov 1;13(13). [Epub ahead of print]
• Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is triggered by constitutively activated BCR-ABL and SRC family tyrosine kinases.They account for the activations of multiple growth-signaling pathways, including Raf/MEK/ERK, Akt/mTOR and STAT5 pathways. The BCR-ABL tyrosine ki
• PMID 22895079

• PLCγ, G-protein of the Gαq type and cADPr pathway are associated to trigger the fertilization Ca(2+) signal in the sea urchin egg.

• Tosca L, Glass R, Bronchain O, Philippe L, Ciapa B.SourceINSERM U935/Université Paris Sud/AP-HP, Histologie-Embryologie-Cytogénétique, Hôpital Antoine Béclère, 92141 Clamart, France.
• Cell calcium.Cell Calcium.2012 Nov;52(5):388-96. doi: 10.1016/j.ceca.2012.06.006. Epub 2012 Jul 10.
• In all species, fertilization triggers in the egg a rapid and transient increase of intracellular free calcium (Ca(i)), but how this signal is generated following sperm and egg interaction has not been clearly characterised yet. In sea urchin, a signalling pathway involving tyrosine kinase and PLCγ
• PMID 22784667

Japanese Journal

• Effects of Halogenation on Tyrosine Phosphorylation and Peptide Binding to the Src Homology 2 Domain of Lymphocyte-Specific Protein Tyrosine Kinase

• Okamura Toshimitsu,Kikuchi Tatsuya,Nodaira Mika [他],Odaka Kenichi,Fukushi Kiyoshi,Irie Toshiaki
• Biological and Pharmaceutical Bulletin 35(3), 433-437, 2012
• … Phosphorylation of tyrosine residues by protein tyrosine kinases (PTK) and phosphotyrosine/Src homology 2 (SH2) domain interactions are crucial not only for signal transduction but also for regulation of PTK activity. … Tyrosine residues also receive nitration and halogenation under oxidative conditions. …
• NAID 130001872328

• Protein Tyrosine Phosphatase SHP-2 Is Positively Involved in Platelet-Derived Growth Factor-Signaling in Vascular Neointima Formation via the Reactive Oxygen Species-Related Pathway

• Won Kyung-Jong,Lee Hwan Myung,Lee Chang-Kwon [他],LIN Hai Yue,NA Haerang,LIM Ki Won,ROH Hui Yul,SIM Seobo,SONG Hyuk,CHOI Wahn Soo,LEE Seung Hyun,KIM Bokyung
• Journal of pharmacological sciences 115(2), 164-175, 2011-02-20
• … The roles of Src homology domain 2–containing protein tyrosine phosphatase 2 (SHP-2) and its signaling in atherosclerosis have not been explored. … PDGF-BB increased the phosphorylations of spleen tyrosine kinase (Syk) and p38 mitogen-activated protein kinase (MAPK), which were recovered by inhibition of SHP-2. …
• NAID 10029891994

• Apoptosis-Inducing Effects of Two Anthraquinones from Hedyotis diffusa WILLD.(Molecular and Cell Biology)

• Shi Ying,Wang Chen-Hui,Gong Xing-Guo
• Biological & pharmaceutical bulletin 31(6), 1075-1078, 2008-06-01
• … Two anthraquinones which inhibit activity of the Src tyrosine kinase were isolated from a water extract of Hedyotis diffusa WILLD. … Both compounds showed inhibitory activity against protein tyrosine kinases v-src and pp60src and arrested the growth of SPC-1-A, Bcap37 and HepG2 cancer cells. …
• NAID 110006684319

Related Links

• Src Tyrosine Kinase - RCSB Protein Data Bank - RCSB PDB

Many Moving Parts Src undergoes a large articulated motion when it turns "on" and "off." The crystal structure, shown on the right from PDB entry 2src, shows the inactive form. The protein opens up, as shown on the left, to ...

• Src protein-tyrosine kinase structure and regulation.

1. Biochem Biophys Res Commun. 2004 Nov 26;324(4):1155-64. Src protein-tyrosine kinase structure and regulation. Roskoski R Jr(1). Author information: (1)Department of Biochemistry and Molecular Biology, Louisiana ...

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★リンクテーブル★

リンク元	「Srcタンパク質チロシンキナーゼ」「Src-family kinase」「Src tyrosine kinase」「Src kinase」
関連記事	「kinase」「S」「Sr」

「Srcタンパク質チロシンキナーゼ」

　　[★]

英

Src protein-tyrosine kinase

関

Srcファミリーキナーゼ、Srcキナーゼ、Srcファミリーチロシンキナーゼ、Srcチロシンキナーゼ

「Src-family kinase」

　　[★]

Srcファミリーキナーゼ

関

SFK、Src kinase、Src protein-tyrosine kinase、Src tyrosine kinase、Src-family tyrosine kinase

「Src tyrosine kinase」

　　[★]

• Srcチロシンキナーゼ

関

Src kinase、Src protein-tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

「Src kinase」

　　[★]

Srcキナーゼ

関

Src protein-tyrosine kinase、Src tyrosine kinase、Src-family kinase、Src-family tyrosine kinase

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「S」

　　[★]

• セリン serine
• 胸骨上縁

　 　

「Sr」

　　[★] ストロンチウム strontium