Src-family kinase

出典: meddic


SFKSrc kinaseSrc protein-tyrosine kinaseSrc tyrosine kinaseSrc-family tyrosine kinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/30 15:27:00」(JST)

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  • A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.
  • Eastman BM, Jo M, Webb DL, Takimoto S, Gonias SL.AbstractBinding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive breast cancer cell lines, ERK activation occurs autonomously of uPA and is sustained. Autonomous ERK activation by uPAR requires H-Ras and Rac1. A mutated form of uPAR, which does not bind vitronectin (uPAR-W32A), failed to induce autonomous ERK activation. Expression of human uPAR or mouse uPAR but not uPAR-W32A in MCF-7 cells provided a selection advantage when these cells were deprived of estrogen in cell culture for two weeks. Similarly, MCF-7 cells that express mouse uPAR formed xenografts in SCID mice that survived and increased in volume in the absence of estrogen supplementation, probably reflecting the pro-survival activity of phospho-ERK. Autonomous uPAR signaling to ERK was sensitive to the EGFR tyrosine kinase inhibitors, Erlotinib and Gefitinib. The transition in uPAR signaling from uPA-dependent and transient to autonomous and sustained is reminiscent of the transformation in ErbB2/HER2 signaling observed when this gene is amplified in breast cancer. uPAR over-expression may provide a pathway for escape of breast cancer cells from ERα-targeting therapeutics.
  • Cellular signalling.Cell Signal.2012 Sep;24(9):1847-55. Epub 2012 May 19.
  • Binding of urokinase-type plasminogen activator (uPA) to its receptor, uPAR, in estrogen receptor-α (ERα) expressing breast cancer cells, transiently activates ERK downstream of FAK, Src family kinases, and H-Ras. Herein, we show that when uPAR is over-expressed, in two separate ERα-positive brea
  • PMID 22617030
  • p130Cas-dependent actin remodelling regulates myogenic differentiation.
  • Kawauchi K, Tan WW, Araki K, Abu Bakar FB, Kim M, Fujita H, Hirata H, Sawada Y.Source*Mechanobiology Institute, National University of Singapore, Level 10, T-Lab, 5A Engineering Drive 1, Singapore 117411.
  • The Biochemical journal.Biochem J.2012 Aug 1;445(3):323-32.
  • Actin dynamics are implicated in various cellular processes, not only through the regulation of cytoskeletal organization, but also via the control of gene expression. In the present study we show that the Src family kinase substrate p130Cas (Cas is Crk-associated substrate) influences actin remodel
  • PMID 22587391


  • Neutrophil-derived resistin release induced by Aggregatibacter actinomycetemcomitans.
  • Furugen Reiko,Hayashida Hideaki,Yoshii Yumiko,Saito Toshiyuki
  • FEMS Microbiology Letters 321(2), 175-182, 2011-08
  • … Pretreatment of neutrophils with a monoclonal antibody to CD18, β chain of lymphocyte function-associated molecule 1 (LFA-1), or an Src family tyrosine kinase inhibitor before incubation with the highly leukotoxic strain inhibited the release of resistin. …
  • NAID 120003751834
  • Inhibition of E-Cadherin Dependent Cell-Cell Contact Promotes MUC5AC Mucin Production through the Activation of Epidermal Growth Factor Receptors
  • IWASHITA Jun,OSE Kyohei,ITO Hiroki,MURATA Jun,ABE Tatsuya
  • Bioscience, biotechnology, and biochemistry 75(4), 688-693, 2011-04-23
  • … Furthermore, treatment of the NCI-H292 cells with anti-E-cadherin antibody stimulated phosphorylation of extracellular signal-regulated kinase (ERK). … The enhanced production of MUC5AC was inhibited with an EGFR inhibitor and with a MEK inhibitor, but not with a Src family kinase inhibitor. …
  • NAID 10028271470


Src family kinase is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in ...
It belongs to a family of non-receptor tyrosine kinases called Src family kinases. The discovery of Src family proteins has been instrumental to the modern understanding of cancer as a disease where normally healthy cellular signalling has ...


analysis after receptor tyrosine kinase  :// Src family tyrosine kinasesthe src family of tyrosine kinases are Src-family kinases (src Kinases; Protein  Src-Tyrosine Kinase Fyn in T-Lymphocytes

先読みSrc-family tyrosine kinase
リンク元Srcファミリーキナーゼ」「Src protein-tyrosine kinase」「Src tyrosine kinase」「Src kinase」「SFK

Src-family tyrosine kinase」

  [★] Srcファミリーチロシンキナーゼ



Src-family kinaseSFK

Src protein-tyrosine kinase」


Src kinaseSrc tyrosine kinaseSrc-family kinaseSrc-family tyrosine kinase

Src tyrosine kinase」


Src kinaseSrc protein-tyrosine kinaseSrc-family kinaseSrc-family tyrosine kinase

Src kinase」



Src protein-tyrosine kinaseSrc tyrosine kinaseSrc-family kinaseSrc-family tyrosine kinase



Src-family kinase



  • n.

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「people descended from a common ancestor; "his family has lived in Massachusetts since the Mayflower"」
family line, folk, kinfolk, kinsfolk, sept, phratry

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「primary social group; parents and children; "he wanted to have a good job before starting a family"」
family unit

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「an association of people who share common beliefs or activities; "the message was addressed not just to employees but to every member of the company family"; "the church welcomed new members into its fellowship"」

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「a social unit living together; "he moved his family to Virginia"; "It was a good Christian household"; "I waited until the whole house was asleep"; "the teacher asked how many people made up his home"」
household, house, home, menage

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「(biology) a taxonomic group containing one or more genera; "sharks belong to the fish family"」

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「《集合的に》『家族』,家庭 / 〈U〉《時にa family》(一家の)子供たち / 〈C〉(血縁に関係ある)『親族』,身内,一族,一門 / 〈U〉『家柄』;(特に)名門 / 〈C〉(関係ある人・物の)一団,一群,(生物分類の)科《+『of』+『名』》」



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「the 19th letter of the Roman alphabet」

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「sulfurの化学記号 / {略}South[ern]」


  [★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase

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「an enzyme that catalyzes the conversion of a proenzyme to an active enzyme」


  [★] ストロンチウム strontium

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「the basic unit of money in Papua New Guinea」