PRP

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/15 12:29:55」(JST)

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英文文献

  • Biodegradable borosilicate bioactive glass scaffolds with a trabecular microstructure for bone repair.
  • Gu Y1, Wang G2, Zhang X1, Zhang Y2, Zhang C2, Liu X3, Rahaman MN3, Huang W4, Pan H5.Author information 1Department of Materials Science and Engineering, Tongji University, Shanghai 200092, China.2Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.3Department of Materials Science and Engineering, and Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.4Department of Materials Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address: whhuang@tongji.edu.cn.5Department of Orthopaedics & Traumatology, The University of Hong Kong, 999077, Hong Kong, China.AbstractThree-dimensional porous scaffolds of a borosilicate bioactive glass (designated 13-93B1), with the composition 6Na2O-8K2O-8MgO-22CaO-18B2O3-36SiO2-2P2O5 (mol%), were prepared using a foam replication technique and evaluated in vitro and in vivo. Immersion of the scaffolds for 30days in a simulated body fluid in vitro resulted in partial conversion of the glass to a porous hydroxyapatite composed of fine needle-like particles. The capacity of the scaffolds to support bone formation in vivo was evaluated in non-critical sized defects created in the femoral head of rabbits. Eight weeks post-implantation, the scaffolds were partially converted to hydroxyapatite, and they were well integrated with newly-formed bone. When loaded with platelet-rich plasma (PRP), the scaffolds supported bone regeneration in segmental defects in the diaphysis of rabbit radii. The results indicate that these 13-93B1 scaffolds, loaded with PRP or without PRP, are beneficial for bone repair due to their biocompatibility, conversion to hydroxyapatite, and in vivo bone regenerative properties.
  • Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2014 Mar 1;36:294-300. doi: 10.1016/j.msec.2013.12.023. Epub 2013 Dec 27.
  • Three-dimensional porous scaffolds of a borosilicate bioactive glass (designated 13-93B1), with the composition 6Na2O-8K2O-8MgO-22CaO-18B2O3-36SiO2-2P2O5 (mol%), were prepared using a foam replication technique and evaluated in vitro and in vivo. Immersion of the scaffolds for 30days in a simulated
  • PMID 24433915
  • Molecular dynamics studies on the NMR and X-ray structures of rabbit prion proteins.
  • Zhang J1, Zhang Y2.Author information 1Graduate School of Sciences, Information Technology and Engineering, & Centre of Information and Applied Optimization, The University of Ballarat, Mount Helen Campus, MT Helen, Victoria 3353, Australia. Electronic address: j.zhang@ballarat.edu.au.2School of Basic Medical Sciences, Taishan Medical University, Shandong 271000, China.AbstractPrion diseases, traditionally referred to as transmissible spongiform encephalopathies (TSEs), are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species, manifesting as scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad-cow disease) in cattle, chronic wasting disease in deer and elk, and Creutzfeldt-Jakob diseases, Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia, and kulu in humans, etc. These neurodegenerative diseases are caused by the conversion from a soluble normal cellular prion protein (PrP(C)) into insoluble abnormally folded infectious prions (PrP(Sc)), and the conversion of PrP(C) to PrP(Sc) is believed to involve conformational change from a predominantly α-helical protein to one rich in β-sheet structure. Such a conformational change may be amenable to study by molecular dynamics (MD) techniques. For rabbits, classical studies show that they have a low susceptibility to be infected by PrP(Sc), but recently it was reported that rabbit prions can be generated through saPMCA (serial automated Protein Misfolding Cyclic Amplification) in vitro and the rabbit prion is infectious and transmissible. In this paper, we first do a detailed survey on the research advances of rabbit prion protein (RaPrP) and then we perform MD simulations on the NMR and X-ray molecular structures of rabbit prion protein wild-type and mutants. The survey shows to us that rabbits were not challenged directly in vivo with other known prion strains and the saPMCA result did not pass the test of the known BSE strain of cattle. Thus, we might still look rabbits as a prion resistant species. MD results indicate that the three α-helices of the wild-type are stable under the neutral pH environment (but under low pH environment the three α-helices have been unfolded into β-sheets), and the three α-helices of the mutants (I214V and S173N) are unfolded into rich β-sheet structures under the same pH environment. In addition, we found an interesting result that the salt bridges such as ASP201-ARG155, ASP177-ARG163 contribute greatly to the structural stability of RaPrP.
  • Journal of theoretical biology.J Theor Biol.2014 Feb 7;342:70-82. doi: 10.1016/j.jtbi.2013.10.005. Epub 2013 Oct 31.
  • Prion diseases, traditionally referred to as transmissible spongiform encephalopathies (TSEs), are invariably fatal and highly infectious neurodegenerative diseases that affect a wide variety of mammalian species, manifesting as scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or ma
  • PMID 24184221
  • Interaction of membrane/lipid rafts with the cytoskeleton: Impact on signaling and function: Membrane/lipid rafts, mediators of cytoskeletal arrangement and cell signaling.
  • Head BP1, Patel HH1, Insel PA2.Author information 1VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA; Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.2Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: pinsel@ucsd.edu.AbstractThe plasma membrane in eukaryotic cells contains microdomains that are enriched in certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form membrane/lipid rafts (MLR). These regions exist as caveolae, morphologically observable flask-like invaginations, or as a less easily detectable planar form. MLR are scaffolds for many molecular entities, including signaling receptors and ion channels that communicate extracellular stimuli to the intracellular milieu. Much evidence indicates that this organization and/or the clustering of MLR into more active signaling platforms depends upon interactions with and dynamic rearrangement of the cytoskeleton. Several cytoskeletal components and binding partners, as well as enzymes that regulate the cytoskeleton, localize to MLR and help regulate lateral diffusion of membrane proteins and lipids in response to extracellular events (e.g., receptor activation, shear stress, electrical conductance, and nutrient demand). MLR regulate cellular polarity, adherence to the extracellular matrix, signaling events (including ones that affect growth and migration), and are sites of cellular entry of certain pathogens, toxins and nanoparticles. The dynamic interaction between MLR and the underlying cytoskeleton thus regulates many facets of the function of eukaryotic cells and their adaptation to changing environments. Here, we review general features of MLR and caveolae and their role in several aspects of cellular function, including polarity of endothelial and epithelial cells, cell migration, mechanotransduction, lymphocyte activation, neuronal growth and signaling, and a variety of disease settings. This article is part of a Special Issue entitled: Reciprocal influences between cell cytoskeleton and membrane channels, receptors and transporters. Guest Editor: Jean Claude Hervé.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2014 Feb;1838(2):532-45. doi: 10.1016/j.bbamem.2013.07.018. Epub 2013 Jul 27.
  • The plasma membrane in eukaryotic cells contains microdomains that are enriched in certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form membrane/lipid rafts (MLR). These regions exist as caveolae, morphologically observable flask-like invaginations, or as a less easily
  • PMID 23899502

和文文献

  • PRP療法 (特集 美容外科・抗加齢医療 : 基本から最先端まで) -- (再生治療)
  • 抗凝固・抗血小板とアンチエイジング(シリーズ1-1)血小板とアンチエイジング : アンチエイジングにおける多血小板血漿(PRP)療法の有用性(第10回)皮膚のアンチエイジングにおける多血小板血漿(PRP)療法の有用性 : 難治性皮膚潰瘍・褥瘡治療からみた血小板の皮膚軟部組織への影響
  • 楠本 健司
  • Anti-aging science : 脳心血管抗加齢研究会機関誌 7(1), 49-54, 2015-03
  • NAID 40020427711
  • 微分不可能な関数を含む非線形方程式系に対するPRP型平滑化スケーリング共役勾配法について (最適化アルゴリズムの進展 : 理論・応用・実装)
  • 成島 康史,大谷 亮介,矢部 博
  • 数理解析研究所講究録 1931, 67-78, 2015-01
  • NAID 110009881115

関連リンク

『W-PRP』は自身の血液を使う最先端の皮膚再生療法で、目元のシワ・たるみを切らずに解消します。血小板を使用する再生医療は「PRP療法」という手法が一般的ですが、オザキクリニックでは「PRP療法」をより進化させた『W-PRP ...
PRP(多血小板血漿)注入による皮膚再生療法に関するご紹介。レーザー治療専門の美容皮膚科シロノクリニックは、日本最大規模の最新レーザー・光治療機器等135台以上完備、症例数15万例以上の実積(グループ総数)。美しく年を ...

関連画像

What Is PRP Therapy and How Does It Work 療法(自己多血小板血漿療法 PRPsuggests that Platelet-rich Plasma (PRP removed intramuscular injections of PRP Jornal A Verdade: PP, PRP e PPL fazem


★リンクテーブル★
先読み多血小板血漿
リンク元遅発性ウイルス性脳炎」「進行性風疹脳炎」「panretinal photocoagulation
拡張検索PRPP合成酵素」「PRPPシンテターゼ」「PRP-OMP vaccine」「PRP vaccine」「PRPP synthetase superactivity
関連記事PR」「P

多血小板血漿」

  [★]

platelet-rich plasma



遅発性ウイルス性脳炎」

  [★]

slow viral encephalitis


遅発性ウイルス性脳炎の分類 IMD.1048

  病名 病原体 頻度

ウイルス
SSPE 麻疹ウイルス 100万人に1人
PML JCウイルス 100万人に1人
PRP 風疹ウイルス 世界で20例程度
プリオン病 CJD プリオン蛋白:? 100万人に1人
変異型CJD プリオン蛋白:? 主に英国
Kuru病 プリオン蛋白:? はぽ消滅
GSS プリオン蛋白:? CJDの数%

PRPとSSPEの臨床的特徴 IMD.1048

  PRP SSPE
病因ウイルス 風疹 麻疹
感染時期 子宮内 2歳未満
発症年鈴 10-12歳 5-15歳
性差 男性 男性>女性
臨床症状 認知症、小脳失調 認知症、除脳硬直ミオクローヌス
臨床経過 慢性進行性 亜急性進行性
発症~死亡 約10年 約5年
脳病変の強度 小脳>大脳 小脳<大脳


進行性風疹脳炎」

  [★]

progressive rubella panencephalitis
PRP


panretinal photocoagulation」

  [★]

PRP
PRP


PRPP合成酵素」

  [★]

PRPP synthetase
ホスホリボシルピロリン酸合成酵素PRPPシンテターゼ


PRPPシンテターゼ」

  [★]

PRPP synthetase
ホスホリボシルピロリン酸合成酵素PRPP合成酵素


PRP-OMP vaccine」

  [★]

polyribosylribitrol phosphate-outer membrane protein


PRP vaccine」

  [★]

polyribosylribitrol phosphate


PRPP synthetase superactivity」

  [★]

phosphoribosylpyrophosphate


PR」

  [★]


PrepTutorEJDIC   license prepejdic

「public relations」


P」

  [★]


WordNet   license wordnet

「the 16th letter of the Roman alphabet」
p

PrepTutorEJDIC   license prepejdic

「parking」

PrepTutorEJDIC   license prepejdic

「phosphorusの化学記号」


"http://meddic.jp/PRP" より作成


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