PAR

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/07 16:51:18」(JST)

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英文文献

  • Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.
  • Jones TA1, Nikolova LS1, Schjelderup A1, Metzstein MM2.Author information 1Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.2Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: markm@genetics.utah.edu.AbstractBranching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to investigate branching morphogenesis that occurs at the single cell level. Here, we show that the exocyst, a conserved protein complex that facilitates docking and tethering of vesicles at the plasma membrane, is required for terminal cell branch outgrowth. We find that exocyst-deficient terminal cells have highly truncated branches and show an accumulation of vesicles within their cytoplasm and are also defective in subcellular lumen formation. We also show that vesicle trafficking pathways mediated by the Rab GTPases Rab10 and Rab11 are redundantly required for branch outgrowth. In terminal cells, the PAR-polarity complex is required for branching, and we find that the PAR complex is required for proper membrane localization of the exocyst, thus identifying a molecular link between the branching and outgrowth programs. Together, our results suggest a model where exocyst mediated vesicle trafficking facilitates branch outgrowth, while de novo branching requires cooperation between the PAR and exocyst complexes.
  • Developmental biology.Dev Biol.2014 Jun 1;390(1):41-50. doi: 10.1016/j.ydbio.2014.02.021. Epub 2014 Mar 4.
  • Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increase surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respir
  • PMID 24607370
  • Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice.
  • Butturini E1, Di Paola R2, Suzuki H1, Paterniti I2, Ahmad A2, Mariotto S3, Cuzzocrea S4.Author information 1Department of Life and Reproduction Sciences, Section of Biochemistry, University of Verona, Verona, Italy.2Department of Biological and Environmental Sciences, University of Messina, 98166 Messina, Italy.3Department of Life and Reproduction Sciences, Section of Biochemistry, University of Verona, Verona, Italy. Electronic address: sofia.mariotto@univr.it.4Department of Biological and Environmental Sciences, University of Messina, 98166 Messina, Italy; Manchester University, Manchester, United Kingdom. Electronic address: salvator@unime.it.AbstractThe aim of this study was to investigate the effect of costunolide (CS) and dehydrocostuslactone (DCE) a well-known sesquiterpene lactones contained in many plants, in a model of lung injury induced by carrageenan administration in the mice. Injection of carrageenan into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear cells (PMNs) as well as an infiltration of PMNs in lung tissues and increased production of tumour necrosis factor α (TNF-α). All parameters of inflammation were attenuated by CS and DCE (15mg/kg 10% DMSO i.p.) administered 1h before carrageenan. Carrageenan induced an up regulation of the intracellular adhesion molecules-1 (ICAM-1) and P-selectin, as well as nitrotyrosine and poly (ADP-ribose) (PAR) as determined by immunohistochemical analysis of lung tissues. The degree of staining for the ICAM-1, P-selectin, nitrotyrosine and PAR was reduced by CS and DCE. Additionally we show that this inflammatory events were associated with NF-κB and STAT3 activation and these sesquiterpenes down-regulated it. Taken together, ours results clearly shown that CS and DCE may offer a novel therapeutic approach for the management of inflammatory diseases.
  • European journal of pharmacology.Eur J Pharmacol.2014 May 5;730:107-15. doi: 10.1016/j.ejphar.2014.02.031. Epub 2014 Mar 10.
  • The aim of this study was to investigate the effect of costunolide (CS) and dehydrocostuslactone (DCE) a well-known sesquiterpene lactones contained in many plants, in a model of lung injury induced by carrageenan administration in the mice. Injection of carrageenan into the pleural cavity of mice e
  • PMID 24625594
  • Effects of protease activated receptor (PAR)2 blocking peptide on endothelin-1 levels in kidney tissues in endotoxemic rat mode.
  • Jesmin S1, Shimojo N2, Yamaguchi N3, Mowa CN4, Oki M5, Zaedi S6, Sultana SN7, Rahman A8, Islam M9, Sawamura A10, Gando S11, Kawano S12, Miyauchi T13, Mizutani T14.Author information 1Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Health and Disease Research Center for Rural Peoples, Dhaka, Bangladesh; Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan. Electronic address: jsubrina@gmail.com.2Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: nokeshimojo@yahoo.co.jp.3Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan. Electronic address: yamaguchi@ipu.ac.jp.4Department of Biology, Appalachian State University, NC, USA. Electronic address: mowacn@appstate.edu.5Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: s1321258@u.tsukuba.ac.jp.6Health and Disease Research Center for Rural Peoples, Dhaka, Bangladesh; Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan. Electronic address: zaedi0728@yahoo.com.7Health and Disease Research Center for Rural Peoples, Dhaka, Bangladesh.8Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Health and Disease Research Center for Rural Peoples, Dhaka, Bangladesh. Electronic address: rarif111@yahoo.com.9Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan; Health and Disease Research Center for Rural Peoples, Dhaka, Bangladesh. Electronic address: majedul1987@yahoo.com.10Department of Critical Care Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.11Department of Critical Care Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. Electronic address: Gando@med.hokudai.ac.jp.12Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: kawano_s@md.tsukuba.ac.jp.13Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: t-miyauc@md.tsukuba.ac.jp.14Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: mizutani@md.tsukuba.ac.jp.AbstractAIMS: Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the pathogenesis of sepsis and its complications. Protease-activated receptors (PARs) are shown to play an important role in the interplay between inflammation and coagulation. We examined the time-dependent alterations of ET-1 and inflammatory cytokine, such as tumor necrosis factor (TNF)-α in kidney tissue in lipopolysaccharide (LPS)-induced septic rat model and the effects of PAR2 blocking peptide on the LPS-induced elevations of renal ET-1 and TNF-α levels.
  • Life sciences.Life Sci.2014 May 2;102(2):127-33. doi: 10.1016/j.lfs.2014.03.013. Epub 2014 Mar 16.
  • AIMS: Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor,
  • PMID 24641950

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関連リンク

※サイト内に掲載されているコードは、コード使用上の注意をよく読んでご利用ください。 ※プロアクションリプレイ(PAR)は、秘技コード・攻略コードを使ったゲーム攻略ツールです。プロアクションリプレイシリーズについては、 ...
par 【他動】《ゴルフ》〔ホールを〕パーにする 【名】 等価、等位、同等 標準、... - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。

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★リンクテーブル★
先読み通年性アレルギー性鼻炎
リンク元肺血管抵抗」「プロテアーゼ受容体」「プロテアーゼ活性化受容体」「proteinase-activated receptor」「protease-activated receptor
拡張検索PPAR
関連記事par」「PA」「P

通年性アレルギー性鼻炎」

  [★]

perennial allergic rhinitis
慢性アレルギー性鼻炎鼻炎
[show details]


肺血管抵抗」

  [★]

pulmonary vascular resistance PVR
全肺血管抵抗肺小動脈抵抗?? PAR??
体血管抵抗


定義

  • 肺血管抵抗 PVR = ( 平均肺動脈圧(PA) - 平均左房圧(LA) ) / 肺血流量(Qp)



プロテアーゼ受容体」

  [★]

protease-activated receptorproteinase-activated receptorPAR
プロテアーゼ活性化受容体プロテアーゼ活性化レセプター

プロテアーゼ活性化受容体」

  [★]

protease-activated receptorproteinase-activated receptorPAR
プロテアーゼ受容体プロテアーゼ活性化レセプター


proteinase-activated receptor」

  [★]

PARprotease-activated receptor

protease-activated receptor」

  [★]

プロテアーゼ活性化受容体プロテアーゼ受容体

PARproteinase-activated receptor


PPAR」

  [★]

peroxisome proliferator-activated receptor
peroxisome proliferator activated receptor-7
  • 転写因子。核内受容体。
肝臓に多く発現して、脂肪酸の分解に関わる
脂肪細胞の分化を抑制し、脂肪貯蔵に関わる



par」

  [★]

  • comb form.
para
  • ex.

WordNet   license wordnet

「make a score (on a hole) equal to par」

WordNet   license wordnet

「(golf) the standard number of strokes set for each hole on a golf course, or for the entire course; "a par-5 hole"; "par for this course is 72"」

PrepTutorEJDIC   license prepejdic

「〈U〉同等,同価,同水準,同程度 / (また『par value』)〈U〉平価,額面価格 / 〈U〉(程度・質・状態・数量などの)平均,標準;(精神・健康などの)常態 / 〈C〉(ゴルフで)標準打数,パー / 《名詞の前にのみ用いて》平均の,標準の / 額面の」

PrepTutorEJDIC   license prepejdic

「(ゴルフで)〈1ホールまたは1コース〉‘を'基準打数でとる,パーで上がる」


PA」

  [★]


PrepTutorEJDIC   license prepejdic

「personal assistant個人秘書 / public address [system]」


P」

  [★]


WordNet   license wordnet

「the 16th letter of the Roman alphabet」
p

PrepTutorEJDIC   license prepejdic

「parking」

PrepTutorEJDIC   license prepejdic

「phosphorusの化学記号」


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