出典: meddic


N-methyl-4-phenyl- 1 ,2,3 ,6-tetrahy- ▲ dropyridine
N-methyl-4-phenyl- 1 ,2,3 ,6-tetrahy- ▲ dropyridine

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/19 10:57:28」(JST)

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  • Pro-inflammatory cytokines modulate iron regulatory protein 1 expression and iron transportation through reactive oxygen/nitrogen species production in ventral mesencephalic neurons.
  • Wang J, Song N, Jiang H, Wang J, Xie J.SourceDepartment of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao 266071, China.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2013 May;1832(5):618-25. doi: 10.1016/j.bbadis.2013.01.021. Epub 2013 Jan 31.
  • Both inflammatory processes associated with microglia activation and abnormal iron deposit in dopaminergic neurons are involved in the pathogenesis of Parkinson's disease (PD). However, the relationship between neuroinflammation and iron accumulation was not fully elucidated. In the present study, w
  • PMID 23376588
  • Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites.
  • Jiang P, Gan M, Ebrahim AS, Castanedes-Casey M, Dickson DW, Yen SH.SourceDepartment of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
  • Neurobiology of aging.Neurobiol Aging.2013 May;34(5):1504-15. doi: 10.1016/j.neurobiolaging.2012.11.001. Epub 2012 Nov 28.
  • Neuronal inclusions of α-synuclein (α-syn), termed Lewy bodies, are a hallmark of Parkinson disease (PD). Increased α-syn levels can occur in brains of aging human and neurotoxin-treated mice. Because previous studies have shown increased brain lactate levels in aging brains, in PD affected subje
  • PMID 23200460
  • Estrogen receptors and lesion-induced response of striatal dopamine receptors.
  • Al Sweidi S, Morissette M, Rouillard C, Di Paolo T.SourceFaculty of Pharmacy, Laval University, Quebec City, QC, Canada G1K 7P4; Neuroscience unit, Centre de recherche du CHU de Québec, Quebec City, QC, Canada G1V 4G2.
  • Neuroscience.Neuroscience.2013 Apr 16;236:99-109. doi: 10.1016/j.neuroscience.2012.12.058. Epub 2013 Jan 26.
  • Neuroprotection by 17β-estradiol and an estrogen receptor (ER) agonist against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesion were shown to implicate protein kinase B (Akt) signaling in mice. In order to evaluate the associated mechanisms, this study compared estrogen receptor alpha (ER
  • PMID 23357113


  • The effect of Ndrg2 expression on astroglial activation
  • Takeichi Toshiaki,Takarada-Iemata Mika,Hashida Koji,Sudo Hirofumi,Okuda Tomohiko,Kokame Koichi,Hatano Taku,Takanashi Masashi,Funabe Sayaka,Hattori Nobutaka,Kitamura Osamu,Kitao Yasuko,Hori Osamu
  • Neurochemistry International 59(1), 21-27, 2011-08
  • … To study the expression and possible role of Ndrg2 in quiescent and activated astrocytes, mice were administrated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP), a Parkinson disease (PD)-related neurotoxin which causes both neurodegeneration and glial activation. …
  • NAID 120003221535
  • Neuroprotective Effect of Kaempferol against a 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Mouse Model of Parkinsons Disease
  • Li Shen,Pu Xiao-Ping
  • Biological & Pharmaceutical Bulletin 34(8), 1291-1296, 2011
  • … In the present study, we investigated the neuroprotective effects of kaempferol in the mouse model of Parkinsons disease, which was induced by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). … We confirmed that MPTP led to behavioral deficits, depletion of dopamine and its metabolites, reduction in superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, and the elevation of malondialdehyde (MDA) levels in the substantia nigra. …
  • NAID 130000936601


MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a neurotoxin precursor to MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used in ...


Description MPTP structure.pngMetabolisme van MPTP vanuit een haarvat PubChem on MPTPMPTPMPTP and MPP+ toxicity Neuronal and glial Synthesis Reference(s) for MPTP

拡張検索MPTP誘発実験的パーキンソニズム」「MPTP-induced experimental parkinsonism」「MPTP中毒



1-methyl-4-phenyl-1, MPTP
1-メチル-4-フェニル-1,2,3,6-テトラヒドロピリジン 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

  • 黒質緻密部のドーパミン作動性ニューロンが脱落
  • パーキンソン病に似た症状を引き起こす。



substantia nigra pars compacta

  • 中脳
  • ドーパミン作動性ニューロン
  • 黒質線条体ニューロン








MPTP-induced experimental parkinsonism

MPTP-induced experimental parkinsonism」


autosomal dominant parkinsonismautosomal recessive juvenile Parkinson diseaseautosomal recessive juvenile parkinsonismautosomal recessive parkinsonismexperimental parkinsonismjuvenile Parkinson diseasejuvenile parkinsonism、parkinsonian disorder、parkinsonian syndromeparkinsonism



MPTP poisoning




  [★] 最長発声持続時間

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