MAPK kinase

MAPキナーゼキナーゼ

関

MAP kinase kinase、MAPK-ERK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

WordNet

1. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
2. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. Massachusetts / mental age

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/05/23 04:02:49」(JST)

wiki en

[Wiki en表示]

"MKK" redirects here. For other uses, see MKK (disambiguation).

Mitogen-activated protein kinase kinase
Identifiers
EC number	2.7.12.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).

MAP2K is classified as EC 2.7.12.2.

There are seven genes:

• MAP2K1 (a.k.a. MEK1)
• MAP2K2 (a.k.a. MEK2)
• MAP2K3 (a.k.a. MKK3)
• MAP2K4 (a.k.a. MKK4)
• MAP2K5 (a.k.a. MKK5)
• MAP2K6 (a.k.a. MKK6)
• MAP2K7 (a.k.a. MKK7)

The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. The acronym MEK derives from MAPK/ERK Kinase.

Role in melanoma

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis(controlled cell death) is induced.

See also

• Signal transduction
• MAP kinase
• MAP kinase kinase kinase
• MAP kinase kinase kinase kinase

References

External links

• Mitogen-Activated Protein Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
• 2. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
• 3. 前立腺癌の分子生物学 molecular biology of prostate cancer
• 4. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
• 5. 赤痢菌感染の疫学、微生物学、および病因 epidemiology microbiology and pathogenesis of shigella infection

English Journal

• The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.

• Kim B1, Breton S2.
• Biology of reproduction.Biol Reprod.2016 Dec;94(1):22. doi: 10.1095/biolreprod.115.134965. Epub 2015 Dec 9.
• The initial segment (IS) in rodents is functionally and structurally distinct from other epididymal segments and plays an important role in sperm maturation. The MAPK/ERK1/2 pathway is maintained active in the IS by testicular luminal factors and plays crucial roles in the maintenance and differenti
• PMID 26658708

• Effects of urban particulate matter with high glucose on human monocytes U937.

• Zhang Y1,2, Mo Y1, Gu A3, Wan R4, Zhang Q1, Tollerud DJ1.
• Journal of applied toxicology : JAT.J Appl Toxicol.2016 Apr;36(4):586-95. doi: 10.1002/jat.3198. Epub 2015 Jul 14.
• Epidemiological studies and animal experiments have shown that individuals with preexisting diseases, such as diabetes mellitus (DM), are more susceptible to particulate matter (PM)-related cardiovascular diseases. However, the underlying mechanisms are still unclear. We hypothesized that PM and hig
• PMID 26179980

• Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway.

• Hu P1, Huang BY1, Xia X1, Xuan Q2, Hu B1, Qin YH3.
• Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Apr;36(2):213-9. doi: 10.3109/10799893.2015.1075041. Epub 2015 Oct 13.
• Renal osteodystrophy (ROD) is highly prevalent in chronic kidney disease (CKD). Because most patients with ROD are asymptomatic in the early stage and bone biopsy remains not a routine procedure in many clinical settings; therefore, several biochemical parameters may help to identify the existence o
• PMID 26459742

Japanese Journal

• Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway

• Shinomiya Misae,Kawamura Kenji,Tanida Emiko,Nagoshi Megumi,Motoda Hirotoshi,Kasanami Yoshiko,Hiragami Fukumi,Kano Yoshio
• Acta Medica Okayama 66(2), 111-118, 2012-04
• … Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. … We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. … After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. …
• NAID 120004040526

• Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells

• Seki Sayaka,Aoki Miho,Hosokawa Toshiyuki,Saito Takeshi,Masuma Runa,Komori Miyako,Kurasaki Masaaki
• Chemico-Biological Interactions 194(1), 23-30, 2011-10-15
• … As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK. …
• NAID 120003483496

Related Links

• MAPK経路とは - WWW3 関西医大学術サーバ

MAPK経路とは MAP kinase（mitogen-activated protein kinase、以下MAPK）は、酵母から植物・高等動物に至るまで広く真核生物に保存されたセリン／スレオニンキナーゼであり、活性化にともなって核内へと移行することから、細胞外の ...

• MAPK カスケード (Mitogen-Activated Protein Kinase Cascades)

米国CST社の日本法人CSTジャパン株式会社【公式サイト】MAPK カスケード (Mitogen-Activated Protein Kinase Cascades)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。

Related Pictures

---

★リンクテーブル★

リンク元	「mitogen-activated protein kinase kinase」「MAPK-ERK kinase」
関連記事	「MAP」「MA」「kinase」

「mitogen-activated protein kinase kinase」

　　[★]

MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ

関

MAP kinase kinase、MAPK kinase、MAPK-ERK kinase、MAPKK、MEK

「MAPK-ERK kinase」

　　[★]

MAPK-ERKキナーゼ

関

MAP kinase kinase、MAPK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

「MAP」

　　[★]

• 僧帽弁輪形成術 mitral annuloplasty
• Miller assessment for Pre-schoolers
• 平均動脈圧 mean arterial pressure
• 平均気道内圧 mean airway pressure
• mannitol adenine phosphate
• リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「MA」

　　[★]

• 僧帽弁閉鎖症 僧帽弁閉鎖 mitral atresia
• 僧帽弁輪 mitral annulus

　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase