LDL-receptor related protein 1

出典: meddic


alpha 2-macroglobulin receptorapoE receptorapolipoprotein E receptor

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  • ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation.
  • Sen A1, Nelson TJ2, Alkon DL2.
  • The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2015 May 13;35(19):7538-51. doi: 10.1523/JNEUROSCI.0260-15.2015.
  • Apolipoprotein E4 (ApoE4) is a major genetic risk factor for several neurodegenerative disorders, including Alzheimer's disease (AD). Epigenetic dysregulation, including aberrations in histone acetylation, is also associated with AD. We show here for the first time that ApoE4 increases nuclear trans
  • PMID 25972179
  • Antisense RNA Controls LRP1 Sense Transcript Expression through Interaction with a Chromatin-Associated Protein, HMGB2.
  • Yamanaka Y1, Faghihi MA1, Magistri M1, Alvarez-Garcia O2, Lotz M2, Wahlestedt C3.
  • Cell reports.Cell Rep.2015 May 12;11(6):967-76. doi: 10.1016/j.celrep.2015.04.011. Epub 2015 Apr 30.
  • Long non-coding RNAs (lncRNAs), including natural antisense transcripts (NATs), are expressed more extensively than previously anticipated and have widespread roles in regulating gene expression. Nevertheless, the molecular mechanisms of action of the majority of NATs remain largely unknown. Here, w
  • PMID 25937287
  • Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes.
  • Revuelta-López E1, Cal R1, Herraiz-Martínez A1, de Gonzalo-Calvo D1, Nasarre L1, Roura S2, Gálvez-Montón CC2, Bayes-Genis A2, Badimon L1, Hove-Madsen L1, Llorente-Cortés V3.
  • Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 May 9. pii: S0022-2828(15)00145-5. doi: 10.1016/j.yjmcc.2015.04.028. [Epub ahead of print]
  • The maintenance of sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activity is crucial for cardiac function and SERCA2 is dramatically reduced in the heart exposed to hypoxic/ischemic conditions. Previous work from our group showed that hypoxia upregulates the phosphorylated form of the Ca2+-dependent n
  • PMID 25968337


  • Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor
  • Moritou Yuki,Ikeda Fusao,Iwasaki Yoshiaki,Baba Nobuyuki,Takaguchi Kouichi,Senoh Tomonori,Nagano Takuya,Takeuchi Yasuto,Yasunaka Tetsuya,Ohnishi Hideki,Miyake Yasuhiro,Takaki Akinobu,Nouso Kazuhiro,Yamamoto Kazuhide
  • Acta Medica Okayama 68(1), 17-22, 2014-02
  • … The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. …
  • NAID 120005372642
  • Rapid Development of Atherosclerosis in the World's Smallest Microminipig Fed a High-Fat/High-Cholesterol Diet:A Useful Animal Model Due to its Size and Similarity to Human Pathophysiology
  • , , , , , , , , ,
  • Journal of Atherosclerosis and Thrombosis 21(3), 186-203, 2014
  • … We found that the administration of a high-fat/high-cholesterol diet containing at least 0.2% cholesterol without cholic acid for as little as eight weeks induces hypercholesterolemia and subsequent atherosclerosis in these animals.Results: The serum levels of low-density lipoprotein cholesterol(LDL-C) and the percent distribution of cholesterol in the LDL fractions were markedly increased. …
  • NAID 130004444717
  • Therapeutic Approaches to Vascular Protection in Ischemic Stroke
  • Acta Medica Okayama 65(4), 219-223, 2011-08
  • … In the ischemic brain, free radicals and exogenous tPA itself can trigger MMP-9 activation through several signaling pathways containing LDL receptor-related protein (LRP) and proteinase-activated receptor 1 (PAR1). … Therapeutic targeting of free radicals and MMP-9/t-PA related signaling pathways might be promising approaches to minimizing catastrophic HT in acute stroke patients. …
  • NAID 80021895203


1. Physiol Rev. 2008 Jul;88(3):887-918. doi: 10.1152/physrev.00033.2007. LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Lillis AP(1), Van Duyn LB, Murphy-Ullrich JE ...
Early studies suggested the existence of an hepatic receptor that is involved in the clearance of serpin:enzyme complexes. Subsequent work has identified this receptor as the LDL receptor-related protein 1 (LRP1). LRP1 is a ...
The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in ...


LDL_and_LDL_receptor.giflow - density - lipoproteinLdl-Receptor Related Protein 1LDL Receptor-Related Protein 1: Unique Ldl-Receptor Related Protein 1 related protein associated protein 1

リンク元apoE receptor」「apolipoprotein E receptor」「alpha 2-macroglobulin receptor」「LDL受容体関連タンパク質1」「LDLレセプター関連タンパク質1

apoE receptor」


  • ア・リ・タンパク質E受容体、ア・リ・タンパク質Eレセプター、ア・リ・蛋白E受容体、ア・リ・蛋白Eレセプター、ア・E受容体、ア・Eレセプター、apoE受容体apoEレセプター
alpha 2-macroglobulin receptorapolipoprotein E receptorLDL-receptor related protein 1

apolipoprotein E receptor」


  • ア・リ・タンパク質E受容体、ア・リ・タンパク質Eレセプター、ア・リ・蛋白E受容体、ア・リ・蛋白Eレセプター
alpha 2-macroglobulin receptorapoE receptorLDL-receptor related protein 1

alpha 2-macroglobulin receptor」


apoE receptorapolipoprotein E receptorLDL-receptor related protein 1



LDL-receptor related protein 1



LDL-receptor related protein 1



  • v.
  • 関連する、関係する

WordNet   license wordnet

「have or establish a relationship to; "She relates well to her peers"」

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「be in a relationship with; "How are these two observations related?"」

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「give an account of; "The witness related the events"」

PrepTutorEJDIC   license prepejdic

「(…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》」



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「connected by kinship, common origin, or marriage」

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「being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces"」
related to

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  [★] 蛋白質

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「any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"」

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low density lipoprotein
  • VLDLより由来し、これに含まれるTGがLPLにより分解されて比較的密度の高いLDLが生じる
  • 60%コレステロール、5%トリグリセロール、主要なアポリポ蛋白はapoE


  [★] 受容体

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「a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response」

PrepTutorEJDIC   license prepejdic

「=sense organ / 受信装置」