WordNet

undergo a test; "She doesnt test well"
any standardized procedure for measuring sensitivity or memory or intelligence or aptitude or personality etc; "the test was standardized on a large sample of students" (同)mental test, mental testing, psychometric test
the act of undergoing testing; "he survived the great test of battle"; "candidates must compete in a trial of skill" (同)trial
the act of testing something; "in the experimental trials the amount of carbon was measured separately"; "he called each flip of the coin a new trial" (同)trial, run
a hard outer covering as of some amoebas and sea urchins
put to the test, as for its quality, or give experimental use to; "This approach has been tried with good results"; "Test this recipe" (同)prove, try, try out, examine, essay
achieve a certain score or rating on a test; "She tested high on the LSAT and was admitted to all the good law schools"
determine the presence or properties of (a substance)
show a certain characteristic when tested; "He tested positive for HIV"
an examination of the characteristics of something; "there are laboratories for commercial testing"; "it involved testing thousands of children for smallpox"
the act of subjecting to experimental test in order to determine how well something works; "they agreed to end the testing of atomic weapons"
the 9th letter of the Roman alphabet (同)i
tested and proved useful or correct; "a tested method" (同)tried, well-tried
tested and proved to be reliable (同)time-tested, tried, tried and true

PrepTutorEJDIC

(人の能力などの)『試験』,考査,テスト / (物事の)『試験』,検済,試錬,実験《+of+名》 / 化学分析;試薬 / =test match / …‘を'『試験する』,検査する / …‘を'化学分析する / (…の)試験を受ける,試験をする《+for+名》
『私は』私が
iodineの化学記号

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 肝臓の有機アニオン輸送能および薬物代謝能の検査 tests of the livers capacity to transport organic anions and metabolize drugs
2. 切除可能肝細胞の外科的マネージメント surgical management of potentially resectable hepatocellular carcinoma
3. 肝細胞障害を検出するための肝臓生化学検査 liver biochemical tests that detect injury to hepatocytes
4. Pulmonary artery catheterization: Indications, contraindications, and complications in adults
5. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-グルタミルトランスペプチダーゼなど） enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase

English Journal

Prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhosis with fasting plasma glucose level of <126 mg/dL.

Matsumoto N, Arase Y, Seko Y, Imai N, Kawamura Y, Sezaki H, Hosaka T, Akuta N, Kobayashi M, Kobayashi M, Suzuki Y, Saito S, Suzuki F, Ikeda K, Kumada H, Aida K, Kobayashi T.SourceDepartment of Hepatology and Okinaka Memorial Institute for Medical Research Department of Health Management Center, Toranomon Hospital, Tokyo Department of Third Internal Medicine (Metabolism), University of Yamanashi, Yamanashi, Japan.
Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2012 Jan 11. doi: 10.1111/j.1872-034X.2011.00957.x. [Epub ahead of print]
Aim: The aim of this study was to evaluate the prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhotic patients with fasting plasma glucose (FPG) level of <126 mg/dL. Methods: A total of 263 patients with hepatitis C virus (HCV) or hepatitis B virus (HBV)
PMID 22236146

Quantitative assessment of liver function after ischemia-reperfusion injury and partial hepatectomy in rats.

de Graaf W, Heger M, Spruijt O, Maas A, de Bruin K, Hoekstra R, Bennink RJ, van Gulik TM.SourceDepartment of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
The Journal of surgical research.J Surg Res.2012 Jan;172(1):85-94. Epub 2010 Jul 21.
BACKGROUND: Liver function after hepatic ischemia-reperfusion (I/R) injury and partial liver resection (PHx) is influenced by the extent of PHx, hepatocellular damage, and liver regeneration. This study investigates the effect of minor PHx with increasing degrees of I/R-induced damage on postoperati
PMID 20869070

Advanced Hemodynamic Monitoring before and after Transjugular Intrahepatic Portosystemic Shunt: Implications for Selection of Patients--A Prospective Study.

Saugel B, Phillip V, Gaa J, Berger H, Lersch C, Schultheiss C, Thies P, Schneider H, Höllthaler J, Herrmann A, Schmid RM, Huber W.Source2nd Medical Department, Department of Interventional Radiology, Institute of Radiology, and Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany.
Radiology.Radiology.2012 Jan;262(1):343-52. Epub 2011 Oct 24.
Purpose: To investigate immediate and short-term effects of transjugular intrahepatic portosystemic shunt (TIPS) on cardiocirculatory, hepatic, and renal function and characterize predictors for TIPS outcome in terms of organ function after TIPS. Materials and Methods: This prospective study was ap
PMID 22025732

Japanese Journal

A Custom-Made, Low-Cost Intraoperative Fluorescence Navigation System with Indocyanine Green for Sentinel Lymph Node Biopsy in Skin Cancer

Fujisawa Yasuhiro,Nakamura Yasuhiro,Kawachi Yasuhiro,Otsuka Fujio,藤澤康弘,中村泰大,川内康弘,大塚藤男
Dermatology 222(3), 261-268, 2011-06
… Background: Recently, indocyanine green (ICG) fluorescence imaging has been reported as new method to detect sentinel lymph nodes (SLNs). … Objective: The purpose of this study was to test an ICG fluorescence detection system constructed with parts commonly available on the market and to compare the SLN detection rate with that of the conventional combined dye and RI methods. …
NAID 120003221459

Relationship between Indocyanine Green Clearance Test and Feed Intake and Impaired Hepatic Function in Dairy Cows

ONO Mamiko,OHTAKI Tadatoshi,TANEMURA Kouichi,ISHII Mitsuo,TSUMAGARI Shigehisa
Journal of Veterinary Medical Science advpub(0), 1106210556, 2011
… The purposes of this study were 1) to examine changes in the indocyanine green (ICG) clearance by feeding and 4-day fasting in dry cows, and (2) to investigate the relationship between ICG clearance and blood chemistry profile in postpartum cows. … In three dry cows, post-feeding ICG half-life (T1/2) was shorter than the pre-feeding value, and post-fasting T1/2 was longer than pre-feeding and post-feeding values. …
NAID 130000861826

「インドシアニングリーン試験」

　　[★]

英: indocyanine green test, ICG test
同: インドシアニングリーン負荷試験、インドシアニングリーン排泄試験。(国)ICG試験 ICG test、ICG負荷試験
関: インドシアニングリーン、ブロムスルファレイン試験、肝予備能評価

[show details]

ICG試験 : 約 1,410 件
ICG負荷試験 : 92 件
インドシアニングリーン試験 : 69 件
インドシアニングリーン負荷試験 : 24 件

概念

暗緑色の色素であるインドシアニングリーンを用いた肝機能検査の一つであり、肝の異物排泄機能検査である。
色素の血中消失率(fractional disappearance rate)と血中停滞率(retention rate)(15分停滞率, R15)を算出する。
肝血流と肝細胞の色素摂取機能を反映し、肝硬変の診断や肝予備能の評価などに用いられる。

肝血流 : 肝細胞ICG摂取能力: ICGの胆汁への排泄能力 = 3 : 1 : 1 (QB.B-268)

肝外排泄がほとんどなく、肝臓の初回通過効果が大きいので、R15、KICGは有効肝血流量の良い指標となる
肝硬変の診断や肝予備能の評価などに用いられ、肝切除術の術前検査としては必須である。
BSPと比べて、色素の肝外処理の比率、測定誤差、副作用が少ないなどの利点を有する(LAB.LAB.1357)

動態

血液中ではアルブミン(LAB.1357)・α1-リポ蛋白(医学事典)と結合する。
ICGの90%以上が肝細胞に摂取され、抱合などの代謝を受けずに胆汁中へ排泄される。

判定

基準範囲

LAB.1358

15分血中停滞率(R)：0-10%
血中消失率(K)：0.168-0.206
最大除去率ICG Rmax：3.18±1.62 mg/kg/分

10-30%(中等度上昇)

[高頻度]慢性肝炎　
[可能性]肝硬変

30%以上(高度上昇)

[高頻度・可能性]肝硬変　　→　　80%以上では黄疸、腹水をしたきた重篤な肝不全状態が想定される

疾患・病態との関連

心不全：肝血流を反映するので、異常値を示しうる
高ビリルビン血症：異常値(ビリルビンとICGの処理が競合するため)
ローター症候群
体質性ICG排泄異常症

まとめ

	ICG試験		BSP試験	その他
	血中消失率 (K)	15分血中停滞率 (R15)	血中停滞率 45分値	その他
健常者	0.168-0.206	0-10%	正常
ジルベール症候群	正常⁽¹⁾
デュビン・ジョンソン症候群	正常～軽度異常⁽²⁾		低下後再上昇
ローター症候群		＞70% 70-80⁽³⁾	異常値 45-50%⁽³⁾	黄疸
ICG排泄異常症		＞70%		肝機能検査正常
慢性肝炎	0.1-0.15	10-30%
肝硬変	0.077	＞30%, 平均35%

肝臓での処理	代謝されない		グルタチオン抱合

(1) 正常のことが多い(QB.B-267)、正常か時に中等度の異常(LAB.1358)
(2)(QB.B-267)、正常(LAB.1358)