出典: meddic

[[]] extracellular-signal-regulated kinase
  • MAPKファミリーに含まれるERKファミリーを構成
  • キナーゼサブドメインVIIIの活性化ループに存在するリン酸化部位の配列がTEY
  • セリンスレオニンキナーゼ
  • MAPKKであるMEK1,MEK2によってスレオニンとチロシン残基がリン酸化され、活性化される。
  • ERK1/2の基質

extracellular-signal-regulated kinase

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/19 19:43:32」(JST)

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  • Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance.
  • Liu D, Shi M, Duan C, Chen H, Hu Y, Yang Z, Duan H, Guo N.SourceDepartment of Pathology, Hebei Medical University, Shijiazhuang 050017, PR China.
  • Molecular immunology.Mol Immunol.2013 Nov;56(1-2):104-12. doi: 10.1016/j.molimm.2013.04.007. Epub 2013 May 24.
  • Erbin is ubiquitously expressed in normal epithelial tissues and constitutively associates with Her2 at the basolateral membranes in epithelial cells. The inhibitory role of Erbin in ERK signaling has been demonstrated. However, whether the expression of Erbin is altered in Her2-overexpressing breas
  • PMID 23711387
  • Integrin binding and MAPK signal pathways in primary cell responses to surface chemistry of calcium silicate cements.
  • Shie MY, Ding SJ.SourceInstitute of Oral Science, Chung Shan Medical University, Taichung City 402, Taiwan, ROC.
  • Biomaterials.Biomaterials.2013 Sep;34(28):6589-6606. doi: 10.1016/j.biomaterials.2013.05.075. Epub 2013 Jun 14.
  • Cell attachment, proliferation and differentiation on different materials depend largely on the surface properties of the materials. This study sheds light on the mechanism by which the modulation of the chemical composition of calcium silicate cements with different Si/Ca molar ratios could produce
  • PMID 23768900
  • Cell proliferation is promoted by compressive stress during early stage of chondrogenic differentiation of rat BMSCs.
  • Wang Y, Wang J, Bai D, Song J, Ye R, Zhao Z, Lei L, Hao J, Jiang C, Fang S, An S, Cheng Q, Li J.SourceDepartment of Orthodontics, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Journal of cellular physiology.J Cell Physiol.2013 Sep;228(9):1935-42. doi: 10.1002/jcp.24359.
  • The presence of an appropriate number of viable cells is prerequisite for successive differentiation during chondrogenesis. Chondrogenic differentiation has been reported to be influenced by mechanical stimuli. This research aimed to study the effects of cyclic compressive stress on cell viability o
  • PMID 23629830


  • Isoleucine, an Essential Amino Acid, Induces the Expression of Human β Defensin 2 through the Activation of the G-Protein Coupled Receptor-ERK Pathway in the Intestinal Epithelia
  • 金野陽高,Ashida Toshifumi,Inaba Yuhei,Ito Takahiro,Tanabe Hiroki,Maemoto Atsuo,Ayabe Tokiyoshi,Mizukami Yusuke,Fujiya Mikihiro,Kohgo Yutaka
  • Food and Nutrition Sciences 3(4), 548-555, 2012-04
  • … An inhibitor of either ERK or Gi, a subunit of G-proteins, reduced the in- duction of HBD2 mRNA by Ile. … The treatment with Ile also increased the intracellular calcium ion concentration, thus suggesting that the GPCR and ERK signaling pathway mediate the effects of Ile. … These results indicate that an essential amino acid, Ile, enhances the expression of an inducible β-defensin, namely HBD2, by IL-1α through the activation of GPCRs and ERK signaling pathway. …
  • NAID 120004079258
  • Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes
  • Shimada Kohei,Ohno Yuta,Okamatsu-Ogura Yuko,Suzuki Masahiro,Kamikawa Akihiro,Terao Akira,Kimura Kazuhiro
  • Peptides 34(2), 336-342, 2012-04
  • … Treatment with NPY also failed to induce ERK (Thr202/Tyr204) phosphorylation in the brown adipocytes. … In contrast, treatment with NPY increased ERK phosphorylation in cultured stromal vascular cells from the BAT that express Y1 receptor mRNA. … These results suggest that NPY mainly acts on stromal vascular cells in BAT and plays roles in the regulation of their gene transcription through ERK and STAT3 pathways, while NPY does not affect the thermogenic function of brown adipocytes. …
  • NAID 120004066090
  • Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway
  • Shinomiya Misae,Kawamura Kenji,Tanida Emiko,Nagoshi Megumi,Motoda Hirotoshi,Kasanami Yoshiko,Hiragami Fukumi,Kano Yoshio
  • Acta Medica Okayama 66(2), 111-118, 2012-04
  • … Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. … We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. … After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. …
  • NAID 120004040526


米国CST社の日本法人CSTジャパン株式会社【公式サイト】Erk Signalingページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
ヒト細胞にはERK/p38/JNKという、少なくとも3種類のMAPK経路が存在するが、これら複数の経路間でシグナルの誤った混線は起こらない。MAPK経路の正確なシグナル伝達を保証する機構は、細胞機能の制御に極めて重要であると ...
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Erk1/Erk2 Mapk Signaling pathwayCoordinating ERK/MAPK signalling through ERK signaling pathway PMID 19186160NFkB Pathway Reporter Assay KitModulation of signalling by Sprouty: a AKT TargetsCoordinating ERK/MAPK signalling through

リンク元細胞外シグナル制御キナーゼ」「extracellular signal-regulated kinase」「ERK1」「細胞外シグナル調節キナーゼ
拡張検索MAPK-ERK kinase」「MAPK-ERK kinase 1」「ERK3」「ERK cascade



細胞膜 Grb2
MAPKKK Raf-1/A-Raf
基質 ERK1/ERK2, p90rsk, MNK1/MNK2, Sos, cPLA2, EGFR, Elk-1, Ets1, Sap1a, STAT, Map2, Tau



extracellular signal-regulated kinaseERK

extracellular signal-regulated kinase」



ERKextracellular signal-regulated MAP kinase



細胞外シグナル制御キナーゼ1, extracellular signal-regulated kinase 1




MAPK-ERK kinase」



MAP kinase kinaseMAPK kinaseMAPKKMEKmitogen-activated protein kinase kinase

MAPK-ERK kinase 1」


MAP kinase kinase 1MEK1



extracellular signal-regulated kinase 3

ERK cascade」

  [★] 細胞外シグナル制御キナーゼカスケード





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