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Besifloxacin Ophthalmic Suspension, 0.6%: a Novel Topical Fluoroquinolone for Bacterial Conjunctivitis.

O'Brien TP.SourceOcular Microbiology Laboratory, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Palm Beach Gardens, Miami, Florida, USA, tobrien@med.miami.edu.
Advances in therapy.Adv Ther.2012 Jun 20. [Epub ahead of print]
Acute bacterial conjunctivitis, the most common cause of conjunctivitis, is responsible for approximately 1% of all primary-care consultations. Of the topical ophthalmic antibiotics used to treat acute bacterial conjunctivitis, fluoroquinolones are especially useful because they possess a broad anti
PMID 22729919

Design and synthesis of peptides from bacterial ParE toxin as inhibitors of topoisomerases.

Barbosa LC, Garrido SS, Garcia A, Delfino DB, Santos LD, Marchetto R.SourceUNESP - Institute of Chemistry, Department of Biochemistry and Technological Chemistry, Caixa Postal 355, 14800-900 Araraquara, São Paulo, Brazil.
European journal of medicinal chemistry.Eur J Med Chem.2012 Jun 15. [Epub ahead of print]
Toxin-antitoxin (TA) proteic systems encode a toxin and an antitoxin that regulate the growth and death of bacterial cells under various stress conditions. The ParE protein is a toxin that inhibits DNA gyrase activity and thereby blocks DNA replication. Based on the Escherichiacoli ParE structure, a
PMID 22749642

Contribution of the AcrAB-TolC Efflux Pump to High-Level Fluoroquinolone Resistance in Escherichia coli Isolated from Dogs and Humans

SATO Toyotaka,YOKOTA Shin-ichi,OKUBO Torahiko,ISHIHARA Kanako,UENO Hiroshi,MURAMATSU Yasukazu,FUJII Nobuhiro,TAMURA Yutaka
Journal of Veterinary Medical Science 75(4), 407-414, 2013
… Fluoroquinolone resistance is mainly caused by mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV in Escherichia coli. …
NAID 130002502179

Experimental and Clinical Studies on Fluoroquinolone-insusceptible Escherichia coli Isolated from Patients with Urinary Tract Infections from 1994 to 2007

Wada Koichiro,Kariyama Reiko,Mitsuhata Ritsuko,Uehara Shinya,Watanabe Toyohiko,Monden Koichi,Kumon Hiromi
Acta Medica Okayama 63(5), 263-272, 2009-10
… We analyzed the mutations in quinolone resistance-determining regions of DNA gyrase (gyrA) and topoisomerase IV (parC). …
NAID 120002313204

Molecular characterizations of carbapenem and ciprofloxacin resistance in clinical isolates of Pseudomonas putida

KUMITA Wakako,SAITO Ryoichi,SATO Kenya,ODE Takashi,MORIYA Kyoji,KOIKE Kazuhiko,CHIDA Toshio,OKAMURA Noboru
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 15(1), 6-12, 2009-02-01
NAID 10025128068