CD161

同

NKRP1, NKRP-1

発現細胞

• NK細胞、T細胞

分子量

• 44kDa

機能

• NK細胞の細胞障害性を制御

ファミリー

• C-type lectin

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/13 17:51:54」(JST)

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[Wiki en表示]

Killer cell lectin-like receptor subfamily B, member 1
Identifiers
Symbols	KLRB1; CD161; CLEC5B; NKR; NKR-P1; NKR-P1A; NKRP1A; hNKR-P1A
External IDs	OMIM: 602890 MGI: 107539 HomoloGene: 84369 GeneCards: KLRB1 Gene
Gene Ontology Molecular function • transmembrane signaling receptor activity • carbohydrate binding Cellular component • plasma membrane • integral to membrane Biological process • cell surface receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3820	100043861
Ensembl	ENSG00000111796	ENSMUSG00000079299
UniProt	Q12918	Q0ZUP1
RefSeq (mRNA)	NM_002258	NM_001099918
RefSeq (protein)	NP_002249	NP_001093388
Location (UCSC)	Chr 12: 9.75 – 9.76 Mb	Chr 6: 128.71 – 128.72 Mb
PubMed search	[1]	[2]

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.

Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus. NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand.

References

Further reading

• Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res. 112 (4): 209–16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913. 
• Lanier LL, Chang C, Phillips JH (1994). "Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes.". J. Immunol. 153 (6): 2417–28. PMID 8077657. 
• Poggi A, Costa P, Morelli L, et al. (1996). "Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity.". Eur. J. Immunol. 26 (6): 1266–72. doi:10.1002/eji.1830260613. PMID 8647203. 
• Renedo M, Arce I, Rodríguez A, et al. (1997). "The human natural killer gene complex is located on chromosome 12p12-p13.". Immunogenetics 46 (4): 307–11. doi:10.1007/s002510050276. PMID 9218532. 
• Poggi A, Costa P, Zocchi MR, Moretta L (1997). "Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration.". Eur. J. Immunol. 27 (9): 2345–50. doi:10.1002/eji.1830270932. PMID 9341779. 
• Poggi A, Rubartelli A, Moretta L, Zocchi MR (1998). "Expression and function of NKRP1A molecule on human monocytes and dendritic cells.". Eur. J. Immunol. 27 (11): 2965–70. doi:10.1002/eji.1830271132. PMID 9394825. 
• Poggi A, Costa P, Tomasello E, Moretta L (1998). "IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A-mediated down-regulation of NK cell activation.". Eur. J. Immunol. 28 (5): 1611–6. doi:10.1002/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6. PMID 9603467. 
• Carlyle JR, Martin A, Mehra A, et al. (1999). "Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function.". J. Immunol. 162 (10): 5917–23. PMID 10229828. 
• Ishihara S, Nieda M, Kitayama J, et al. (1999). "CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver.". Eur. J. Immunol. 29 (8): 2406–13. doi:10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-F. PMID 10458753. 
• Iiai T, Watanabe H, Suda T, et al. (2002). "CD161+ T (NT) cells exist predominantly in human intestinal epithelium as well as in liver.". Clin. Exp. Immunol. 129 (1): 92–8. doi:10.1046/j.1365-2249.2002.01886.x. PMC 1906419. PMID 12100027. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors.". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173. 
• Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. doi:10.1073/pnas.0308304101. PMC 373496. PMID 14990792. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
• Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor.". J. Immunol. 175 (12): 7791–5. PMID 16339512. 
• Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.". J. Immunol. 175 (12): 7796–9. PMID 16339513. 
• Pozo D, Valés-Gómez M, Mavaddat N, et al. (2006). "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase.". J. Immunol. 176 (4): 2397–406. PMID 16455998. 
• Christiansen D, Mouhtouris E, Milland J, et al. (2007). "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161).". Xenotransplantation 13 (5): 440–6. doi:10.1111/j.1399-3089.2006.00332.x. PMID 16925668. 
• Rosen, DB, Cao W, et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells.". J. Immunol. 180 (10): 6508–6517. PMC 2577150. PMID 18453569. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

English Journal

• Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease.

• Hinks TS1,2,3.
• Immunology.Immunology.2016 May;148(1):1-12. doi: 10.1111/imm.12582. Epub 2016 Feb 9.
• Mucosal-associated invariant T (MAIT) cells are a novel class of innate-like T cells, expressing a semi-invariant T-cell receptor (TCR) and able to recognize small molecules presented on the non-polymorphic MHC-related protein 1. Their intrinsic effector-memory phenotype, enabling secretion of pro-i
• PMID 26778581

• Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency.

• Cols M1, Rahman A2, Maglione PJ1, Garcia-Carmona Y1, Simchoni N1, Ko HB3, Radigan L1, Cerutti A1, Blankenship D4, Pascual V4, Cunningham-Rundles C5.
• The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2016 Apr;137(4):1206-1215.e6. doi: 10.1016/j.jaci.2015.09.013. Epub 2015 Nov 2.
• BACKGROUND: Common variable immunodeficiency (CVID) is an antibody deficiency treated with immunoglobulin; however, patients can have noninfectious inflammatory conditions that lead to heightened morbidity and mortality.OBJECTIVES: Modular analyses of RNA transcripts in whole blood previously identi
• PMID 26542033

• The Impact of Sex Work Interruption on Blood-Derived T Cells in Sex Workers from Nairobi, Kenya.

• Omollo K1, Boily-Larouche G2, Lajoie J1,2, Kimani M3, Cheruiyot J3, Kimani J1,3, Oyugi J1,3, Fowke KR1,2,4.
• AIDS research and human retroviruses.AIDS Res Hum Retroviruses.2016 Mar 16. [Epub ahead of print]
• BACKGROUND: Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead to recruitment of activated T cells to the FGT, thereby increasing risk of HI
• PMID 26879184

Japanese Journal

• SF-088-3 大腸癌患者における末梢血CD4+CD161+細胞分画とCD4+細胞のIL-10産生能の比較検討(発癌)(SF-088 サージカルフォーラム(88)大腸 基礎-1,第112回日本外科学会定期学術集会)

• 土屋 和代,池田 拓人,佛坂 正幸,石崎 秀信,千々岩 一男
• 日本外科学会雑誌 113(臨時増刊号_2), 404, 2012-03-05
• NAID 110009548362

• P2-068  IL-6阻害剤とTNF阻害剤はRA患者末梢血中のCD4+CD45RO+CCR6+CD161+細胞に異なった影響を及ぼす

• 菊池 潤,椎名 雅史,橋詰 美里,吉本 桂子,亀田 秀人,竹内 勤
• 日本臨床免疫学会会誌 35(4), 360b-360b, 2012
• … イプレクチン様受容体であるCD161が報告された．【目的と方法】RA患者末梢血全血をFACSで解析し，CD4+CD45RO+CCR6+CD161+細胞（以下CD161+細胞とする）のRA病態および治療の影響を探索的に検討した．【結果】RA患者81名（未治療7名，DMARDs治療19名，TNF阻害治療29名，トシリズマブ治療26名），健康成人17名を対象とした．CD4+細胞に占めるCD161+細胞比率はRA無治療群で他の …
• NAID 130003364103

• P1-012  間質性肺炎合併膠原病患者におけるCD161+ Vδ1+ γδT細胞の解析

• 瀬川 誠司,後藤 大輔,堀越 正信,松本 功,住田 孝之
• 日本臨床免疫学会会誌 35(4), 332b-332b, 2012
• … 間質性肺炎合併膠原病患者におけるCD161+ Vδ1+ γδT細胞の機能解析を行う． … ・健常人（HC, n=22），関節リウマチ（RA, n=17），多発性筋炎/皮膚筋炎（PM/DM, n=14），全身性強皮症（SSc, n=35）由来末梢血単核球中のCD161+ Vδ1+ γδT細胞の割合をフローサイトメトリーで解析した． …
• NAID 130003364049

Related Links

• 抗CD161抗体 | サイトメトリードットコム/ベックマン・コールター

CD161抗原は、NKRP1分子とも呼ばれています。分子量44kDaのモノマーもしくは80kDaのジスルフィド結合ホモダイマーとして発現する、 Ⅱ型膜タンパクです。カルボキシル基側末端にあたる細胞外ドメインは、Ca2 + 依存性（C型 ...

• CD161-Expressing Human T Cells - National Center for ...

CD161 as a marker IL-17 producing cells The identity of these CD161-expressing T subsets remained elusive until CD161 was identified as being significantly upregulated in T helper (Th) 17 clones compared to those of ...

Related Pictures

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★リンクテーブル★

リンク元	「ナチュラルキラー細胞」
関連記事	「CD16」「CD1」

「ナチュラルキラー細胞」

　　[★]

英

natural killer cell, NK cell

同

NK細胞

関

単球、自然免疫、LAK細胞、ナチュラルキラー細胞活性、natural killer

概念

• 自然免疫

• リンパ球の5-10%を占めるらしい。

Large granular lymphocytes(LGLs) or NK cells account for 5-10% of periphral blood plymphocytes.(HAR.2024)

• 大型のアズール好性顆粒を有する(SMB.41)

• 単球と共に自然免疫に関与
• ウイルス感染細胞やガン細胞を傷害する細胞で、T細胞に特異的なマーカをもたずに直接標的細胞を攻撃する (人間の正常構造と機能 VIIA血管・免疫 p.29)

• 抗体依存性細胞毒性(ADCC)

II型アレルギーにかかわる

分子細胞学的な定義

• 大顆粒リンパ球の形状(15μm以上の大リンパ球。アズール顆粒を3つ以上有する)
• CD56(+), sCD3(-), TCR再構成(-), 胚細胞型
• MHC非拘束性のキラー活性を有する

機能

自然免疫

• activation signalにより、IFN-γの放出や顆粒(パーフォリン、グランザイム)を放出する(IMM.96)

ADCC

• IgGのFc部を結合し、顆粒を放出する(IMM.96)

分子マーカー

• CD16：IgGのFc部に対するレセプター
• CD56：NCAM-I
• NK1.1(NKRP-1 = CD161)

~

• CD8：IL-2に反応してNK細胞が増殖
• CD57：多くの細胞表面で発現

ケモカイン

リガンド	作用	産生
IL-12	NK細胞活性化	INF-γ
IL-18	Th1分化促進

• IL-12,IL-18により活性化され、IFN-γを産生

• IL-2により活性化し、細胞障害能が高まる (SPU.65)

受容体

• NIR

MHC class Iを認識して攻撃を抑制。MHC class Iが少ないと抑制が外れる(IMM.96)

• NKR

「CD16」

　　[★]

同

FcγRIII、低親和性Fcγ受容体 lowaffinity Fcγ receptor

• FcγRIII
• NK細胞の抗体依存性細胞介在性細胞傷害(ADCC)に重要

発現細胞

• 好中球、NK細胞、マクロファージ

機能

• Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity ADCC

「CD1」

　　[★]

同

leucine-6, CD1A through E

種類

• CD1a, CD1b, CD1c, CD1d

発現組織

• 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

• 43-49

機能

• MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens