CD106

出典: meddic

intracellular adhesion molecule 3, ICAM-3:CD50


intracellular adhesion molecule 3, ICAM-3:CD50

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/22 11:52:40」(JST)

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英文文献

  • Lipopolysaccharide induces the interactions of breast cancer and endothelial cells via activated monocytes.
  • Chen C1, Khismatullin DB2.Author information 1Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA.2Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118, USA. Electronic address: damir@tulane.edu.AbstractThe adhesion of circulating cancer cells to vascular endothelium is a key step in hematogenous metastasis. Cancer cell-endothelium interactions are mediated by cell adhesion molecules that can also be involved in the arrest of monocytes and other circulating leukocytes on endothelium in inflammation. Static and microfluidic flow adhesion assays as well as flow cytometry were conducted in this study to elucidate the role of monocytes, bacterial lipopolysaccharide (LPS), and histamine in breast cancer cell adhesion to vascular endothelial cells. Tumor necrosis factor-α (TNF-α) released from LPS-treated monocytes triggered the expression of intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells. Histamine augmented the TNF-α effect, leading to a high number of arrested breast cancer cells under both static and shear flow conditions. LPS-treated monocytes were shown to enhance the arrest of breast cancer cells by anchoring the cancer cells to activated endothelial cells. This anchorage was achieved by binding cancer cell ICAM-1 to monocyte β2 integrins and binding endothelial ICAM-1 and VCAM-1 to monocyte β1 and β2 integrins. The results of this study imply that LPS is an important risk factor for cancer metastasis and that the elevated serum level of histamine further increases the risk of LPS-induced cancer metastasis. Preventing bacterial infections is essential in cancer treatment, and it is particularly vital for cancer patients affected by allergy.
  • Cancer letters.Cancer Lett.2014 Apr 1;345(1):75-84. doi: 10.1016/j.canlet.2013.11.022. Epub 2013 Dec 11.
  • The adhesion of circulating cancer cells to vascular endothelium is a key step in hematogenous metastasis. Cancer cell-endothelium interactions are mediated by cell adhesion molecules that can also be involved in the arrest of monocytes and other circulating leukocytes on endothelium in inflammation
  • PMID 24333719
  • Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRβ in a ligand-independent manner in mesenchymal stem cells.
  • Aomatsu E1, Chosa N1, Nishihira S1, Sugiyama Y2, Miura H3, Ishisaki A1.Author information 1Division of Cellular Biosignal Sciences, Department of Biochemistry, Iwate Medical University, Yahaba, Iwate 028-3694, Japan.2Division of Oral Surgery, Department of Oral and Maxillofacial Surgery, Iwate Medical University School of Dentistry, Morioka, Iwate 020-8505, Japan.3Division of Orthodontics, Department of Developmental Oral Health Science, Iwate Medical University School of Dentistry, Morioka, Iwate 020-8505, Japan.AbstractCell-cell adhesions induce various intracellular signals through hierarchical and synergistic molecular interactions. Recently, we demonstrated that a high cell density induces the expression of vascular cell adhesion molecule-1 (VCAM-1) through the nuclear factor-κB (NF-κB) pathway in human bone marrow-derived mesenchymal stem cells (MSCs). However, the specific molecules that activated the NF-κB pathway were not determined. In the present study, in experiments with receptor tyrosine kinase inhibitors, VCAM-1 expression was completely suppressed by platelet-derived growth factor (PDGF) receptor (PDGFR) inhibitors. In addition, VCAM-1 expression was significantly suppressed by knockdown with PDGFRβ siRNA, but not with PDGFRα siRNA. However, VCAM-1 expression did not increase following treatment with PDGF. The overexpression of N-cadherin, a structural molecule in adherence junctions in MSCs, promoted VCAM-1 expression and induced the marked phosphorylation of the intracellular signaling factor, Src. In addition, VCAM-1 expression and Src phosphorylation were reduced by the overexpression of a dominant negative mutant of N-cadherin. These results suggest that cell-cell adhesion, through N-cadherin, enhances the expression of VCAM-1 via PDGFRβ and the activation of Src in a ligand-independent manner in MSCs.
  • International journal of molecular medicine.Int J Mol Med.2014 Mar;33(3):565-72. doi: 10.3892/ijmm.2013.1607. Epub 2013 Dec 27.
  • Cell-cell adhesions induce various intracellular signals through hierarchical and synergistic molecular interactions. Recently, we demonstrated that a high cell density induces the expression of vascular cell adhesion molecule-1 (VCAM-1) through the nuclear factor-κB (NF-κB) pathway in human bone
  • PMID 24378362
  • Improved adhesion and differentiation of endothelial cells on surface-attached fibrin structures containing extracellular matrix proteins.
  • Filová E, Brynda E, Riedel T, Chlupáč J, Vandrovcová M, Svindrych Z, Lisá V, Houska M, Pirk J, Bačáková L.Author information Department of Biomaterials and Tissue Engineering, Institute of Physiology, Academy of Sciences of the Czech Republic, v.v.i., 142 20 Prague 4, Czech Republic.AbstractCurrently used vascular prostheses are hydrophobic and do not allow endothelial cell (EC) adhesion and growth. The aim of this study was to prepare fibrin (Fb)-based two-dimensional (2D) and three-dimensional (3D) assemblies coated with extracellular matrix (ECM) proteins and to evaluate the EC adhesion, proliferation and differentiation on these assemblies in vitro. Coating of Fb with collagen, laminin (LM), and fibronectin (FN) was proved using the surface plasmon resonance technique. On all Fb assemblies, ECs reached higher cell densities than on polystyrene after 3 and 7 days of culture. Immunoflurescence staining showed better assembly of talin and vinculin into focal adhesion plaques, and also more apparent staining of vascular endothelial cadherin on surface-attached 3D Fb and protein-coated Fb assemblies. On these samples, ECs also contained a lower concentration of intercellular adhesion molecule-1, measured by enzyme-linked immunosorbent assay. Higher concentrations of CD31 (platelet-endothelial cell adhesion molecule-1) were found on 3D Fb coated with LM, and higher concentrations of von Willebrand factor were found on 3D Fb coated with type I collagen or LM in comparison to 2D Fb layers. The results indicate that ECM protein-coated 2D and 3D Fb assemblies can be used for versatile applications in various tissue replacements where endothelialization is desirable, for example, vascular prostheses and heart valves. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 698-712, 2014.
  • Journal of biomedical materials research. Part A.J Biomed Mater Res A.2014 Mar;102(3):698-712. doi: 10.1002/jbm.a.34733. Epub 2013 May 30.
  • Currently used vascular prostheses are hydrophobic and do not allow endothelial cell (EC) adhesion and growth. The aim of this study was to prepare fibrin (Fb)-based two-dimensional (2D) and three-dimensional (3D) assemblies coated with extracellular matrix (ECM) proteins and to evaluate the EC adhe
  • PMID 23723042

和文文献

  • Changes in the expression of CD106, osteogenic genes, and transcription factors involved in the osteogenic differentiation of human bone marrow mesenchymal stem cells
  • LIU Feng,AKIYAMA Yasuto,TAI Sachiko,MARUYAMA Kouji,KAWAGUCHI Yoshihiro,MURAMATSU Kouji,YAMAGUCHI Ken
  • Journal of bone and mineral metabolism 26(4), 312-320, 2008-07-30
  • NAID 10024458551
  • Increased expression of soluble form of vascular cell adhesion molecule-1 aggravates autoimmune arthritis in MRL-Fas^<Ipr> mice
  • OISHI Hisashi,MIZUKI Shinichi,TERADA Miho,KUDO Megumi,ARAKI Kimi,ARAKI Masatake,NOSE Masato,TAKAHASHI Satoru
  • Pathology international 57(11), 734-740, 2007-11-01
  • NAID 10021234200

関連リンク

CD106抗原、VCAM-1(Vascular cell adhesion molecule-1)は、リンパ球のインテグリンα4/β1(VLA-4)およびインテグリンα4/β7に結合する接着分子です。110kDaの膜タンパクで、活性化した内皮細胞や組織マクロファージ、樹状細胞および ...
【発明の詳細な説明】 【技術分野】 【0001】 本発明は、間葉系幹細胞の分化能マーカーとしてのCD106の使用に関する。詳細には、本発明は、CD106発現を指標として用いる、骨分化能又は脂肪分化能を有する間葉系幹細胞の製造 ...

関連画像

CD106 Bren Universal Carriers (x2)Church Websites CD106CD106 Kız Kulesi Kanvas Tablo (CD106CD106Excalibur CD106 CD Bingo Traffic Signs


★リンクテーブル★
リンク元接着分子」「T細胞」「VCAM-1
関連記事CD1」「CD10

接着分子」

  [★]

adhesion molecule
接着因子

接着分子のファミリー

白血球の相互作用に関与している接着分子 (IMM.87)

グループ名 機能 名称 別名 組織分布 リガンド
セレクチン 炭化水素鎖に結合。
白血球-内皮細胞の反応を開始
P-selectin PADGEN CD62P 活性化した内皮細胞、活性化した血小板 PSGL-1, sialyl-Lewisx
E-selectin ELAM-1 CD62E 活性化した内皮細胞 sialyl-Lewisx
インテグリン CAMや細胞外マトリックスに結合。
強い結合
LFA-1 αL:β2 CD11a:CD18 単球、T細胞、マクロファージ、好中球、樹状細胞 ICAMs
CR3, Mac-1 αM:β2 CD11b:CD18 好中球、単球、マクロファージ ICAM-1, iC3b, fibrinogen
CR4, p150.95 αX:β2 CD11c:CD18 樹状細胞、マクロファージ、好中球 iC3b
VLA-5 α5:β1 CD49d:CD29 単球、マクロファージ fibronectin
免疫グロブリンスーパーファミリー 細胞結合で様々に働く。
インテグリンの基質
ICAM-1   CD54 活性化した内皮細胞 LFA-1, MAC1
ICAM-2   CD102 非活性化状態の内皮細胞、樹状細胞 LFA-1
VCAM-1   CD106 活性化した内皮細胞 VLA-4
PECAM   CD31 活性化した白血球、内皮細胞間の結合 CD31

白血球の相互作用に関与している免疫グロブリンスーパーファミリーの接着分子 (IMM.329)

名称 分布組織 リガンド
CD2 LFA-2 T細胞 LFA-1 CD53
ICAM-1 CD54 活性化した血管、リンパ球、樹状細胞 LFA-1, Mac-1  
ICAM-2 CD102 非活性化状態の血管 LFA-1  
ICAM-3 CD50 Naive T cells DC-SIGN, LFA-1  
LFA-3 CD58 リンパ球、APC CD2  
VCAM-1 CD106 活性化した内皮細胞 VLA-4  
-接着分子
-細胞接着分子
-カドヘリン


T細胞」

  [★]

T cell
Tリンパ球T lymphocyte
TCRB細胞MHC
  • 図:IMM.315(T細胞の成熟)
  • 胸腺で成熟したT細胞は血流によって移動し、リンパ節の傍皮質白脾髄のリンパ性動脈周囲鞘、パイエル板の傍濾胞域に集まる(人間の正常構造と機能 VIIA血管・免疫 p.28)

種類

  1. ヘルパーT細胞(Th細胞)
  2. キラーT細胞(Tc細胞)
  3. サプレッサーT細胞(Treg細胞)

T細胞の抗原認識 (SP.248)

  CD TCRが抗原と共に認識する分子 認識する細胞
Tc細胞 CD8 MHCクラスI 感染細胞
Th細胞 CD4 MHCクラスII 抗原提示細胞

CD4+ T細胞のサイトカイン放出とその原因

DCが認識する外来異物 DCが分泌する物質 DCに反応する細胞 この細胞が分泌する
サイトカイン
NK系の細胞が放出した
サイトカインに反応するTh細胞
Th細胞が分泌するサイトカイン
ウイルス、一部の細菌 IL-12 NK細胞(IL-12による) INF-γ Th1 IL-2, IFN-γ, TNF-β
原虫など   NKT細胞 IL-4 Th2 IL-4, IL-13, IL-5

Th細胞活性化と接着分子

  抗原提示細胞 Th細胞
主シグナル MHC classII TCR, CD3
CD4
副シグナル B7{B7-1(CD80)/B7-2(CD86)} CD28
VCAM-1(CD106) VLA-4
ICAM-1 LFA-1
LFA-3(CD58) CD2


VCAM-1」

  [★]

vascular cell adhesion molecule 1
CD106
  • インテグリン(VLA-1 integlin)と接着
CD106
vascular cell adhesion molecule 1


CD1」

  [★]

leucine-6, CD1A through E

種類

  • CD1a, CD1b, CD1c, CD1d

発現組織

  • 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

  • 43-49

機能

  • MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens


CD10」

  [★]

common acute lymphoid leukemia antigen, nephrilysin

発現細胞

  • B細胞T細胞前駆体。骨髄間質細胞(bone marrow stromal cell)

分子量

  • 100kDa

機能

  • Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL)

別名

  • Neutral endopeptidase, common acute lymphocytic leukemia antigen(CALLA)



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