B-cell development and differentiation

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英文文献

  • Notch and its ligands in alloimmunity and rejection.
  • Magee CN1, Riella LV.
  • Current opinion in organ transplantation.Curr Opin Organ Transplant.2016 Feb;21(1):15-21. doi: 10.1097/MOT.0000000000000266.
  • PURPOSE OF REVIEW: The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides an overview of the mechanisms of Notch signaling, focusing on new insights into its diverse fu
  • PMID 26626420
  • Biological effects of IL-21 on different immune cells and its role in autoimmune diseases.
  • Gharibi T1, Majidi J2, Kazemi T2, Dehghanzadeh R2, Motallebnezhad M2, Babaloo Z3.
  • Immunobiology.Immunobiology.2016 Feb;221(2):357-67. doi: 10.1016/j.imbio.2015.09.021. Epub 2015 Oct 1.
  • Interleukin-21 (IL-21) is a member of the common γ-chain cytokines with broad pleiotropic actions that affects different immune and nonimmune cells. IL-21 can affect differentiation, proliferation and function of T and B cells; it can also induce the maturation and enhance the cytotoxicity of CD8+
  • PMID 26466984
  • The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection.
  • Wikenheiser DJ1, Ghosh D1, Kennedy B1, Stumhofer JS2.
  • Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Jan 15;196(2):778-91. doi: 10.4049/jimmunol.1403206. Epub 2015 Dec 14.
  • Blood-stage Plasmodium chabaudi chabaudi AS infection requires cell- and Ab-mediated immunity to control acute and persistent infection, respectively. ICOS regulates CD4(+) T cell activation and promotes the induction of follicular Th (TFH) cells, CD4(+) T cells that support B cell affinity maturati
  • PMID 26667167

和文文献

  • 制御性B細胞の分化誘導因子と作用機序に関する検討
  • 吉崎 歩,TEDDER Thomas F.
  • 日本臨床免疫学会会誌 38(1), 57-64, 2015
  • …   近年,B細胞の働きは単に抗体を産生するのみではなく,抗原提示や炎症性サイトカインの産生,T細胞をはじめとする免疫細胞の活性化誘導など,炎症反応において中心的な役割を果たすことが知られるようになってきた.B細胞は炎症反応を誘導するだけでなく,活性化した炎症細胞に作用することで,免疫抑制作用をも発揮することが知られているが,著者らのグループでは,この中でも特にin …
  • NAID 130004875952
  • The Association of nm23-H1 Expression with a Poor Prognosis in Patients with Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Journal of Clinical and
  • … The nm23 genes play critical roles in cellular proliferation, differentiation, oncogenesis, and tumor metastasis. … Peripheral T-cell lymphoma (PTCL) is relatively rare, accounting for only 10% to 15% of non-Hodgkins lymphomas. … We examined whether nm23-H1 is a prognostic factor of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). …
  • NAID 130004705263

関連リンク

B cell development and differentiation Peter D Burrows, Max D Cooper Division of Developmental and Clinical Immunology, Department of Medicine, Pediatrics and Microbiology, and the Howard Hughes Medical Institute, University of ...
Research Topics B Cell Development and Differentiation B cell development and differentiation occurs in multiple phases. The initial, antigen-independent phase generates mature, immunocompetent B cells that can bind to a unique ...

関連画像

cell anergy: from transgenic models to  in B cell activation and differentiationIII. Regulation of B cell developmentFigure 5 - B cell differentiationcell differentiationcell+differentiation


★リンクテーブル★
関連記事development」「and」「cell」「B」「differentiation

development」

  [★]

  • n.
buildupdeploymentdevelopdevelopmentalemergenceengenderevolutionexpandexploitexploitationgenerategenerationgrowthoccuroccurrenceonsettranspireunfold
growth and development


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「processing a photosensitive material in order to make an image visible; "the development and printing of his pictures took only two hours"」
developing

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「a process in which something passes by degrees to a different stage (especially a more advanced or mature stage); "the development of his ideas took many years"; "the evolution of Greek civilization"; "the slow development of her skill as a writer"」
evolution

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「a state in which things are improving; the result of developing (as in the early part of a game of chess); "after he saw the latest development he changed his mind and became a supporter"; "in chess your should take care of your development before moving your queen"」

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「act of improving by expanding or enlarging or refining; "he congratulated them on their development of a plan to meet the emergency"; "they funded research and development"」

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「(music) the section of a composition or movement (especially in sonata form) where the major musical themes are developed and elaborated」

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「a district that has been developed to serve some purpose; "such land is practical for small park developments"」

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「a recent event that has some relevance for the present situation; "recent developments in Iraq"; "what a revolting development!"」

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「〈U〉〈C〉『発達』,発展,発育,成長;『開発』;進化 / 〈U〉(写真の)現像 / 〈C〉発達(発展)の結果できたもの / 〈C〉開発した土地(地区);(特に)住宅団地(housing development) / 〈C〉(最近の)でき事,新事実」


and」

  [★]

PrepTutorEJDIC   license prepejdic

「《語・句・節を対等に結んで》…『と』…,…や…,および / 《数詞を結合して》…『足す』…,…に加えて / …『しかも』…,…して,同時に… / 《時間的に》『そして』,それから,すると(and then) / 《当然の帰結として》…『ので』,…だから(and so) / 《おもに話》《命令文などの後で》『そうすれば』,そうしたら / 《追加・強調して》それに,しかも / 《対照的な内容を導いて》ところが,しかし(but) / 《譲歩的に》それなのに,それでいながら / 《A and Bで一体の関係を表して》《単数扱い》 / 《同一語を反復して多数・継続などを表して》 / 《同一の複数名詞を結合して変化・種類などを表して》 / 《話》《「形容詞+and+形容詞」の形で前の形容詞が後に副詞的に働く》 / 《話》《「動詞come, goなど+and+動詞」の形でandとその後の動詞が不定詞の働きをして》 / 《「動詞+and+動詞」の形で後の動詞が現在分詞の意を表して》 / 《話》《文頭において前の質問・意見などに同意を示して》そうとも,そして(Yes!and) / 《話》《文頭に置いて驚き・疑念・非難などを表して》ほんとうに;…なのに」


cell」

  [★] 細胞

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「small room in which a monk or nun lives」
cubicle

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「a device that delivers an electric current as the result of a chemical reaction」
electric cell

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「a room where a prisoner is kept」
jail cell, prison cell

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「(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals」

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「any small compartment; "the cells of a honeycomb"」

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「a small unit serving as part of or as the nucleus of a larger political movement」
cadre

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「(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞」


B」

  [★]

  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

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「the 2nd letter of the Roman alphabet」
b

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「the blood group whose red cells carry the B antigen」
type B, group B


differentiation」

  [★]

  • n.
differentiatedifferentiativespecialization

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「the mathematical process of obtaining the derivative of a function」

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「a discrimination between things as different and distinct; "it is necessary to make a distinction between love and infatuation"」
distinction




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