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1. 成人における慢性膵炎の病因および発症機序 etiology and pathogenesis of chronic pancreatitis in adults
2. 慢性膵炎における超音波内視鏡検査 endoscopic ultrasound in chronic pancreatitis
3. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
4. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
5. 進行性多巣性白質脳症：疫学、臨床症状、および診断 progressive multifocal leukoencephalopathy epidemiology clinical manifestations and diagnosis

Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.

Hendrix A, Sormunen R, Westbroek W, Lambein K, Denys H, Sys G, Braems G, Van den Broecke R, Cocquyt V, Gespach C, Bracke M, De Wever O.SourceLaboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium; Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Aug 15;133(4):843-54. doi: 10.1002/ijc.28079. Epub 2013 Mar 7.
The secretory Rab27B small GTPase promotes invasive growth and metastasis in estrogen receptor (ER) α-positive breast cancer cells by orchestrating the peripheral targeting of vesicles secreting proinvasive growth regulators. Increased Rab27B expression is associated with poor prognosis in breast c
PMID 23390068

Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria.

Bentz J, O'Connor MP, Bednarczyk D, Coleman J, Lee C, Palm J, Pak YA, Perloff ES, Reyner E, Balimane P, Brännström M, Chu X, Funk C, Guo A, Hanna I, Herédi-Szabó K, Hillgren K, Li L, Hollnack-Pusch E, Jamei M, Lin X, Mason AK, Neuhoff S, Patel A, Podila L, Plise E, Rajaraman G, Salphati L, Sands E, Taub ME, Taur JS, Weitz D, Wortelboer HM, Xia CQ, Xiao G, Yabut J, Yamagata T, Zhang L, Ellens H.SourceGlaxoSmithKline Pharmaceuticals, Drug Metabolism and Pharmacokinetics, 709 Swedeland Road, King of Prussia, PA 19406-0939. harma.m.ellens@gsk.com.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2013 Jul;41(7):1347-66. doi: 10.1124/dmd.112.050500. Epub 2013 Apr 25.
A P-glycoprotein (P-gp) IC50 working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC50 determinations. Each laboratory followed its in-house protocol to determine in vitro IC50
PMID 23620485

Redundant function of two Arabidopsis COPII components, AtSec24B and AtSec24C, is essential for male and female gametogenesis.

Tanaka Y, Nishimura K, Kawamukai M, Oshima A, Nakagawa T.SourceDepartment of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane University, Nishikawatsu 1060, Matsue, 690-8504, Japan.
Planta.Planta.2013 Jun 19. [Epub ahead of print]
Anterograde vesicle transport from the endoplasmic reticulum to the Golgi apparatus is the start of protein transport through the secretory pathway, in which the transport is mediated by coat protein complex II (COPII)-coated vesicles. Therefore, most proteins synthesized on the endoplasmic reticulu
PMID 23779001

Cytosolic PLA_2 in Zymogen Granule Fusion and Amylase Release : Inhibition of GTP-induced Fusion by Arachidonyl Trifluoromethyl Ketone Points to cPLA_2 in G-Protein-mediated Secretory Vesicle Fusion

Establishment and characterization of amylase-producing lung adenocarcinoma cell line, IMEC-2.

Yokouchi Hiroshi,Yamazaki Koichi,Asahina Hajime,Shigemura Masahiko,Moriyama Takanori,Takaoka Kazuo,Moriya Jun,Itoh Tomoo,Kinoshita Ichiro,Dosaka-Akita Hirotoshi,Tsutsumi Yutaka,Nishimura Masaharu
26(4B), 2821-2827, 2006-07
… Electron microscopy revealed zymogen granule-like structures. …
NAID 120000963023