WordNet
- relating to or characteristic of the western parts of the world or the West as opposed to the eastern or oriental parts; "the Western world"; "Western thought"; "Western thought"
- a sandwich made from a western omelet (同)western sandwich
- lying toward or situated in the west; "our companys western office"
- of or characteristic of regions of the United States west of the Mississippi River; "a Western ranch"
- resembling a horse
- hoofed mammals having slender legs and a flat coat with a narrow mane along the back of the neck (同)equid
- of or belonging to the family Equidae
- inflammation of the brain usually caused by a virus; symptoms include headache and neck pain and drowsiness and nausea and fever (`phrenitis is no longer in scientific use) (同)cephalitis, phrenitis
- a film about life in the western United States during the period of exploration and development (同)horse_opera
PrepTutorEJDIC
- 『西の』;西へ向かう;(風などが)西からの / 《しばしば Western》『西洋の』 / 《しばしば Western》西部の,(特に)米国西部の / 《通例 Western》(共産圏に対して)西側の / 西部劇;米国の開拓時代を描いた小説
- 馬の;馬のような
- 脳炎
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/26 11:35:46」(JST)
[Wiki en表示]
| Western equine encephalitis virus |
|
| CryoEM model of western equine encephalitis virus, 12Å resolution. EMDB entry EMD-5210[1] |
| Virus classification |
| Group: |
Group IV ((+)ssRNA) |
| Family: |
Togaviridae |
| Genus: |
Alphavirus |
| Western equine encephalitis virus |
| Classification and external resources |
| ICD-10 |
A83.1 |
| ICD-9 |
062.1 |
| MeSH |
D020241 |
The Western equine encephalomyelitis virus is the causative agent of relatively uncommon viral disease Western equine encephalomyelitis (WEE). An Alphavirus of the family Togaviridae, the WEE virus is an arbovirus (arthropod-borne virus) transmitted by mosquitoes of the genera Culex and Culiseta.[2] WEE is a recombinant virus between two other alphaviruses, an ancestral Sindbis virus-like virus, and an ancestral Eastern equine encephalitis virus-like virus. There have been under 700 confirmed cases in the U.S. since 1964.
In the U.S. WEE is seen primarily in states west of the Mississippi River. The disease is also seen in countries of South America. WEE is commonly a subclinical infection; symptomatic infections are uncommon. However, the disease can cause serious sequelae in infants and children. Unlike Eastern equine encephalitis, the overall mortality of WEE is low (approximately 4%) and is associated mostly with infection in the elderly. There is no vaccine for WEE and there are no licensed therapeutic drugs in the U.S. for this infection.
Contents
- 1 History
- 2 Use as a biological weapon
- 3 See also
- 4 References
- 5 External links
History
WEE was discovered in 1930 when a number of horses in the San Joaquin Valley of California, USA died of a mysterious encephalitis. Karl Friedrich Meyer investigated but was not able to isolate the pathogen from necropsies of horses that had been dead for some time and needed samples from an animal in the earlier stages of disease. When the team heard of a horse that appeared to have encephalitis, its owner threatened to shoot the scientists. However Meyer was able to convince the farmer's wife that the horse was dying anyway, and to secretly signal him when the farmer was asleep in exchange for $20 (as this was during the Great Depression, this was a substantial amount of money). Meyer and his colleagues hid in the bushes until the signal, euthanized the horse and stole its head. They successfully isolated WEEV from the brain tissue.[3]
Use as a biological weapon
Western equine encephalitis virus was one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program.[4]
See also
- Eastern equine encephalitis virus
References
- ^ Sherman, M. B.; Weaver, S. C. (2010). "Structure of the Recombinant Alphavirus Western Equine Encephalitis Virus Revealed by Cryoelectron Microscopy". Journal of Virology 84 (19): 9775–9782. doi:10.1128/JVI.00876-10. PMC 2937749. PMID 20631130. edit
- ^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
- ^ Sabin, Albert (1980), "Karl Friedrich Meyer: 1884—1974", Washington, D.C.: National Academy of Sciences, pp. 295–296
- ^ "Chemical and Biological Weapons: Possession and Programs Past and Present", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed 31 March 2010.
External links
- United States Centers for Disease Control and Prevention (CDC) Fact Sheet
|
Zoonotic viral diseases (A80–B34, 042–079)
|
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| Arthropod-borne |
| Mosquito-borne |
| Bunyaviridae |
- Arbovirus encephalitides: La Crosse encephalitis
- California encephalitis
- Viral hemorrhagic fevers: Rift Valley fever
|
|
| Flaviviridae |
- Arbovirus encephalitides: Japanese encephalitis
- Australian encephalitis
- Saint Louis encephalitis
- West Nile fever
- Viral hemorrhagic fevers: Dengue fever
- Yellow fever
- ZIKV
|
|
| Togaviridae |
- Arbovirus encephalitides: Eastern equine encephalomyelitis
- Western equine encephalomyelitis
- Venezuelan equine encephalomyelitis
- Chikungunya
- O'Nyong-nyong fever
- Ross River fever
- Semliki Forest virus
- Sindbis fever
|
|
| Reoviridae |
|
|
|
| Tick-borne |
| Bunyaviridae |
- Viral hemorrhagic fevers: Crimean–Congo hemorrhagic fever
|
|
| Flaviviridae |
- Arbovirus encephalitides: Tick-borne encephalitis
- Powassan encephalitis
- Viral hemorrhagic fevers: Omsk hemorrhagic fever
- Kyasanur forest disease
- Langat virus (LGTV)
|
|
| Reoviridae |
- Colorado tick fever
- Kemerovo tickborne viral fever
|
|
|
|
| Mammal-borne |
| Rodent-borne |
| Arenaviridae |
- Viral hemorrhagic fevers: Lassa fever
- Venezuelan hemorrhagic fever
- Argentine hemorrhagic fever
- Brazilian hemorrhagic fever
- Bolivian hemorrhagic fever
- LUJV
- CHPV
|
|
| Bunyaviridae |
- Hemorrhagic fever with renal syndrome
- Hantavirus pulmonary syndrome
|
|
|
| Bat-borne |
| Filoviridae |
- Viral hemorrhagic fevers: Ebola virus disease
- BDBV
- EBOV
- SUDV
- TAFV
- Marburg virus disease
- MARV
- RAVV
|
|
| Rhabdoviridae |
|
|
| Paramyxoviridae |
|
|
|
| Primate-borne |
| Herpesviridae |
|
|
| Retroviridae |
- Simian foamy virus
- HTLV-1
- HTLV-2
|
|
| Poxviridae |
- Tanapox
- Yaba monkey tumor virus
|
|
|
| Multiple vectors |
| Rhabdoviridae |
|
|
| Poxviridae |
Monkeypox
|
|
|
|
|
|
|
| Description |
|
|
| Disease |
- Systemic
- Cutaneous
- Zoster
- Human papillomavirus
- Zoonotic
- Symptoms and signs
|
|
| Treatment |
|
|
|
UpToDate Contents
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English Journal
- Inhibition of Dengue Virus by Targeting Viral NS4B Protein.
- Xie X, Wang QY, Xu HY, Qing M, Kramer L, Yuan Z, Shi PY.SourceNovartis Institute for Tropical Diseases, 10 Biopolis Road, Chromos Building, Singapore 138670. pei_yong.shi@novartis.com.
- Journal of virology.J Virol.2011 Nov;85(21):11183-95. Epub 2011 Aug 24.
- We report a novel inhibitor that selectively suppresses dengue virus (DENV) by targeting viral NS4B protein. The inhibitor was identified by screening a 1.8-million-compound library using a luciferase replicon of DENV serotype 2 (DENV-2). The compound specifically inhibits all four serotypes of DENV
- PMID 21865382
Japanese Journal
- Inhibition by Agaricus blazei Murill Fractions of Cytopathic Effect Induced by Western Equine Encephalitis (WEE) Virus on VERO Cells in Vitro(Biochemistry & Molecular Biology)
- SORIMACHI Kenji,IKEHARA Yukari,MAEZATO Genzo,OKUBO Akira,YAMAZAKI Sunao,AKIMOTO Kazumi,NIWA Akira
- Bioscience, biotechnology, and biochemistry 65(7), 1645-1647, 2001-07-23
- … Strong inhibition of CPE induced by western equine encephalitis (WEE) virus was observed in the mycelial fractions but not those of fruiting bodies. …
- NAID 110002693388
Related Links
- Fact Sheet: Western Equine Encephalitis. CLINICAL FEATURES. Symptoms range from mild flu-like illness to frank encephalitis, coma and death. ETIOLOGIC AGENT. Western equine encephalitis virus, member of the family Togaviridae, ...
Related Pictures
![Familie: Togaviridae]](https://1mg.info/0/a/9/2642.jpg)
★リンクテーブル★
[★]
西部ウマ脳脊髄炎
- 関
- western equine encephalitis
[★]
- 西の、西部の、ウエスタン、ウェスタンの、(Wを大文字で用いる例が多数である)エスタンブロットの
- 関
- west、Western blot、Western immunoblot
[★]
ウマの
- 関
- domestic horse、equine、Equus caballus、horse
[★]
- 関
- domestic horse、equi、Equus caballus、horse