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1. カテコラミン誘発多形性心室頻拍および他のQT間隔正常の多形性心室頻拍 catecholaminergic polymorphic ventricular tachycardia and other polymorphic ventricular tachycardias with a normal qt interval
2. 明らかな器質的心疾患のない患者の単形性心室頻脈 monomorphic ventricular tachycardia in the absence of apparent structural heart disease
3. 心室性期外収縮 ventricular premature beats
4. 不整脈原性右室心筋症の臨床症状および診断 clinical manifestations and diagnosis of arrhythmogenic right ventricular cardiomyopathy
5. QRS幅の広い頻脈の診断および治療のアプローチ approach to the diagnosis and treatment of wide qrs complex tachycardias

Electrophysiological effect and the gating mechanism of astragaloside IV on l-type Ca(2+) channels of guinea-pig ventricular myocytes.

Zhao M1, Shao D2, Yu L2, Sun X2, Wang Y2, Hu H2, Feng R2, Gao Q2, Guo F2, Hao L3.
European journal of pharmacology.Eur J Pharmacol.2015 Aug 5;760:27-35. doi: 10.1016/j.ejphar.2015.03.082. Epub 2015 Apr 16.
Astragaloside IV (AS-IV) is one of the main active ingredients of Astragalus membranaceus. This study is aimed to investigate AS-IV׳s effects on Ca(2+) channel activity of single cardiomyocytes and single Ca(2+) channels. Whole-cell Ca(2+) currents in freshly dissociated cardiomyocytes were measure
PMID 25891370

Urocortin2 prolongs action potential duration and modulates potassium currents in guinea pig myocytes and HEK293 cells.

Yang LZ1, Zhu YC2.
European journal of pharmacology.Eur J Pharmacol.2015 Jul 5;758:97-106. doi: 10.1016/j.ejphar.2015.03.078. Epub 2015 Apr 9.
We previously reported that activation of corticotropin releasing factor receptor type 2 by urocortin2 up-regulates both L-type Ca(2+) channels and intracellular Ca(2+) concentration in ventricular myocytes and plays an important role in cardiac contractility and arrhythmogenesis. This study goal wa
PMID 25863256

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.

Kecskés M1, Jacobs G, Kerselaers S, Syam N, Menigoz A, Vangheluwe P, Freichel M, Flockerzi V, Voets T, Vennekens R.
Basic research in cardiology.Basic Res Cardiol.2015 Jul;110(4):501. doi: 10.1007/s00395-015-0501-x. Epub 2015 Jun 5.
Cardiac muscle adapts to hemodynamic stress by altering myocyte size and function, resulting in cardiac hypertrophy. Alteration in myocyte calcium homeostasis is known to be an initial signal in cardiac hypertrophy signaling. Transient receptor potential melastatin 4 protein (TRPM4) is a calcium-act
PMID 26043922

八巻通安,ヤマキミチヤス,Yamaki Michiyasu
山形保健医療研究 = Yamagata Journal of Health Sciences 16, 1-8, 2013-00-00
… 心不全に伴う不整脈の発生機序はいまだ解明されていない．そこで動物心不全モデルを用い，心室の電気的異常と心室不整脈発生との関係を検討した．不全心では1）心尖部における伝導障害とactivation-recovery interval（ARI）の延長を認め，2）再分極のばらつきが増大していた．また心尖部で，3）ARI estitution の急峻化を認めた．不全心におけるこれらの電気的異常は，心室不整脈発生の基質であることが示唆された．そこ …
NAID 120005263108

Activation of Natural Killer T Cells Ameliorates Postinfarct Cardiac Remodeling and Failure in Mice

Sobirin Mochamad Ali,Kinugawa Shintaro,Takahashi Masashige,Fukushima Arata,Homma Tsuneaki,Ono Taisuke,Hirabayashi Kagami,Suga Tadashi,Azalia Putri,Takada Shingo,Taniguchi Masaru,Nakayama Toshinori,Ishimori Naoki,Iwabuchi Kazuya,Tsutsui Hiroyuki
Circulation Research 111(8), 1037-1047, 2012-09-28
… Rationale: Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). … Objective: The purpose of this study was to examine whether the activation of iNKT cells might affect the development of LV remodeling and failure. …
NAID 120005228375

Prognostic Significance of Long-Period Heart Rate Rhythms in Chronic Heart Failure

PASTOR-PEREZ Francisco J.,MANZANO-FERNANDEZ Sergio,GOYA-ESTEBAN Rebeca,PASCUAL-FIGAL Domingo A.,BARQUERO-PEREZ Oscar,ROJO-ALVAREZ Jose Luis,EVERSS Estrella,MARTINEZ-ESPEJO Maria Dolores Martinez,CHAVARRI Mariano Valdes,GARCIA-ALBEROLA Arcadi
Circulation journal : official journal of the Japanese Circulation Society 76(9), 2124-2129, 2012-08-25
… Background: Abnormalities in autonomic control are a feature of neuroendocrine activation in HF and are responsible for dysregulation of biological rhythms. … Methods and Results: In the study, 92 HF patients were enrolled (age 53±14 years and left ventricular ejection fraction [LVEF] 37±10%). …
NAID 10030696480