尿中アルブミン

WordNet

a book of blank pages with pockets or envelopes; for organizing photographs or stamp collections etc
one or more recordings issued together; originally released on 12-inch phonograph records (usually with attractive record covers) and later on cassette audiotape and compact disc (同)record album
of or relating to the urinary system of the body
of or relating to the function or production or secretion of urine
a simple water-soluble protein found in many animal tissues and liquids (同)albumen

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(写真・切手・切り抜きなどを貼る)『アルバム』 / (いくつかの曲・劇などを収録した)組レコード,アルバム / 画帳
尿の;泌尿(ひにょう)[器]の
アルブミン(蛋白質の一種)

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1. 2型糖尿病における、中等度に増加したアルブミン尿（微量アルブミン尿） moderately increased albuminuria microalbuminuria in type 2 diabetes mellitus
2. 微量アルブミン尿および心血管疾患 moderately increased albuminuria microalbuminuria and cardiovascular disease
3. 1型糖尿病における尿中アルブミンの中等度の上昇（微量アルブミン尿） moderately increased albuminuria microalbuminuria in type 1 diabetes mellitus
4. 成人における尿蛋白排泄量の評価および非ネフローゼ域蛋白尿のみの評価 assessment of urinary protein excretion and evaluation of isolated non nephrotic proteinuria in adults
5. 成人における糖尿病に対する治療の概要 overview of medical care in adults with diabetes mellitus

English Journal

The effects of rhodium on the renal function of female Wistar rats.

Iavicoli I1, Leso V2, Fontana L3, Marinaccio A4, Bergamaschi A5, Calabrese EJ6.Author information 1Institute of Public Health, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: iavicoli.ivo@rm.unicatt.it.2Institute of Public Health, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: veruscka@email.it.3Institute of Public Health, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: lfontana73@yahoo.it.4Epidemiology Unit, Occupational Medicine Department, Research Division, Italian Workers' Compensation Authority (INAIL), Via Alessandria, 220/E, 00198 Rome, Italy. Electronic address: a.marinaccio@inail.it.5Institute of Public Health, Catholic University of Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: bergamaschi@rm.unicatt.it.6Department of Public Health, Environmental Health Sciences, University of Massachusetts, Morrill I, N344, Amherst, MA 01003, USA. Electronic address: edwardc@schoolph.umass.edu.AbstractIn recent years, the increased use of rhodium (Rh) as an active catalyst material in modern three-way automobile catalytic converters has led to a parallel rise in environmental levels of this metal. In spite of this, the literature contains few studies of the effects of Rh on human health. The aim of this study is to assess the effects of Rh on the renal function of female Wistar rats. Our findings show that sub-acute exposure to six increasing concentrations, ranging from 0.001 to 1mgL(-1), of Rh (III) chloride hydrate in drinking water does not induce alterations in urinary albumin levels, while, at concentrations from 0.1 to 1mgL(-1), a significant rise in urinary levels of Retinol Binding Protein is evident and an increasing trend in urinary β2-microglobulin, which becomes significant at 1mgL(-1), is observed. These results therefore demonstrate a nephrotoxic action of Rh at tubular level in a wide range of doses. Interestingly, because of the recent increase in environmental Rh levels, these findings may have relevant implications both for occupationally exposed subjects and for the general population, especially children.
Chemosphere.Chemosphere.2014 Jun;104:120-5. doi: 10.1016/j.chemosphere.2013.10.077. Epub 2013 Dec 8.
In recent years, the increased use of rhodium (Rh) as an active catalyst material in modern three-way automobile catalytic converters has led to a parallel rise in environmental levels of this metal. In spite of this, the literature contains few studies of the effects of Rh on human health. The aim
PMID 24321336

Lymphopenia and poor performance status as major predictors for infections among residents in long-term care facilities (LTCFs): A prospective cohort study.

Chang CJ1, Chen LY2, Liu LK3, Lin MH3, Peng LN4, Chen LK5.Author information 1Department of Family Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, No. 100, An-Kan Road, Feng-Yuan District, Taichung City 420, Taiwan.2Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; Aging and Health Research Center, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan; Institute of Public Health, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan.3Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; Aging and Health Research Center, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan.4Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; Aging and Health Research Center, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan; Institute of Public Health, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan. Electronic address: lining.peng@gmail.com.5Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan; Aging and Health Research Center, National Yang Ming University, No. 155, Sec. 2, Li-Nong Street, Taipei 116, Taiwan. Electronic address: lkchen2@vghtpe.gov.tw.AbstractThe main aim of this study was to investigate the risk factors and consequence of LTCFs-acquired infections in Taiwan through a 16-month follow-up. This prospective cohort study invited residents of 10 private LTCFs in Taipei for study. For each participant, Karnofsky Performance Scale (KPS), use of feeding tube and/or urinary catheters, serum levels of albumin, total cholesterol, complete blood count, occurrence of LTCF-acquired infections, all-cause mortality were recorded. Overall, a total of 198 LTCF residents entered the study for a total of 67,395 resident-days, and 156 participants (79.8±9.7 years, 51.3% males) complete the follow-up with a total of 67,395 resident-days. During the study period, 360 LTCF-acquired infections occurred, and the incidence was estimated to be 5.34 episodes per 1000 resident-days. Subjects with LTCF-acquired infections were more likely to die than those without infections. Besides, subjects with lymphopenia and long-term use of feeding tube and/or urinary catheters were significant risk factors for LTCF-acquired infections. However, poorer functional status and occurrence of lower respiratory tract infections were significant predictive factors for all-cause mortality. In conclusion, the period prevalence of LTCF-acquired infections was higher in Taiwan than previous reports, but the incidence was similar. In addition to traditional risk factors, lymphopenia, a surrogate indicator for immunosenescence, was a significant risk factor for LTCF-acquired infections.
Archives of gerontology and geriatrics.Arch Gerontol Geriatr.2014 May-Jun;58(3):440-5. doi: 10.1016/j.archger.2013.12.001. Epub 2013 Dec 16.
The main aim of this study was to investigate the risk factors and consequence of LTCFs-acquired infections in Taiwan through a 16-month follow-up. This prospective cohort study invited residents of 10 private LTCFs in Taipei for study. For each participant, Karnofsky Performance Scale (KPS), use of
PMID 24438878

C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.

Tang Y, Huang XR, Lv J1, Chung AC, Zhang Y2, Chen JZ1, Szalai AJ3, Xu A1, Lan HY.Author information 1*Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.2†Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong.3§Division of Clinical Immunology and Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, U.S.A.AbstractCRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and urea levels (P<0.01) in patients with AKI, which then fell after recovery from AKI. To determine the role of CRP in AKI, an ischaemia/reperfusion mouse model of AKI was developed using Tg (transgenic) mice that express human CRP. Compared with the WT (wild-type) mice, CRP Tg mice developed more severe renal injury at 24 h after ischaemia as determined by significantly increased serum creatinine and tubular necrosis. This was associated with an impaired TEC (tubular epithelium cell) regeneration as shown by an over 60% reduction in PCNA+ (proliferating-cell nuclear antigen) and BrdU+ (bromodeoxyuridine) TECs in CRP Tg mice with AKI. In vitro, the addition of CRP to a human TEC line (HK-2) also largely suppressed the proliferation of TECs. The functional role of CRP in AKI was demonstrated further by the blocking of CRP binding to the FcγRII (Fcγ receptor II) with a neutralizing anti-CD32 antibody, which restored TEC proliferation and prevented AKI in CRP Tg mice. Moreover, we found that impaired G1/S transition by suppression of the phosphorylation of CDK2 (cyclin-dependent kinase 2) and expression of cyclin E may be a key mechanism by which CRP inhibits TEC regeneration during the AKI repair process. In conclusion, CRP plays a pathogenic role in AKI by inhibiting G1/S-dependent TEC regeneration. The results of the present study suggest that targeting CRP signalling may offer a new therapeutic potential for AKI.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 May;126(9):645-59. doi: 10.1042/CS20130471.
CRP (C-reactive protein) is regarded as an inflammatory biomarker in AKI (acute kidney injury), but its exact role in AKI remains unclear. Thus we sought to investigate the role of CRP in AKI. Clinically, elevated serum CRP levels were found to associate closely with increased serum creatinine and u
PMID 24206243

Japanese Journal

S-III-2 Exercise therapy for patients with diabetic nephropathy(The Proceedings of the 21st Annual Meetings of Japan Society of Exercise and Sports Physiology July 27 ・ 28, (Saitama))

SUZUKI Masato
Advances in exercise and sports physiology 19(4), 98, 2013-12
NAID 110009687745

慢性腎臓病と心不全 (特集心腎貧血連関)

大瀧陽一郎,渡邉哲
循環器内科 74(5), 473-478, 2013-11
NAID 40019881636

Effects of the Combination of an Antihypertensive Drug and Exercise on Glucose-lipid Metabolism and Diabetic Nephropathy in Otsuka Long Evans Tokushima Fatty Rats