WordNet

lacking stability or fixity or firmness; "unstable political conditions"; "the tower proved to be unstable in the high wind"; "an unstable world economy"
disposed to psychological variability; "his rather unstable religious convictions"
highly or violently reactive; "sensitive and highly unstable compounds"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency
2. 大腸癌の分子遺伝学 molecular genetics of colorectal cancer
3. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
4. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing
5. 肥満への遺伝的影響と病態生理 genetic contribution and pathophysiology of obesity

Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus.

Pleskovič A1, Šantl Letonja M2, Cokan Vujkovac A3, Makuc J3, Nikolajević Starčević J4,5, Petrovič D6.
International angiology : a journal of the International Union of Angiology.Int Angiol.2018 Feb;37(1):64-70. doi: 10.23736/S0392-9590.17.03853-6. Epub 2017 Oct 9.
PMID 28990744

The potential inhibitory effects of miR‑19b on vulnerable plaque formation via the suppression of STAT3 transcriptional activity.

Li S1, Geng Q2, Chen H1, Zhang J1, Cao C1, Zhang F1, Song J1, Liu C1, Liang W1.
International journal of molecular medicine.Int J Mol Med.2018 Feb;41(2):859-867. doi: 10.3892/ijmm.2017.3263. Epub 2017 Nov 17.
PMID 29207010

Bifunctional activity of fused Plasmodium falciparum orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase.

Paojinda P1, Imprasittichai W2, Krungkrai SR3, Palacpac NMQ4, Horii T4, Krungkrai J5.
Parasitology international.Parasitol Int.2018 Feb;67(1):79-84. doi: 10.1016/j.parint.2017.04.003. Epub 2017 Apr 4.
PMID 28389349

Panel‑based next‑generation sequencing facilitates the characterization of childhood acute myeloid leukemia in clinical settings

Ishida Hisashi,Iguchi Akihiro,Aoe Michinori,Nishiuchi Ritsuo,Matsubara Takehiro,Keino Dai,Sanada Masashi,Shimada Akira
Biomedical Reports 13(5), 46, 2020-11
… These newer drugs selectively target AML cells with specific gene alterations. … This panel‑based, targeted sequencing approach may be useful in determining the genetic background of pediatric AML and improving the prediction of treatment response and detection of potentially targetable gene alterations. … RAS pathway mutations were highly unstable at relapse; …
NAID 120006956811

GENETIC AND MOLECULAR ANALYSES OF P53 IN A JAPANESE FAMILY WITH LI-FRAUMENI SYNDROME

Kodama Koya,Yano Michihiro,Noguchi Atsuko,Uehara Tomoko,Kosaki Kenjiro,Takahashi Tsutomu
秋田医学 = AKITA JOURNAL OF MEDICINE(AKITA IGAKU) 46(3), 91-98, 2020-03-30
… associated with a broad spectrum of early-onset tumors including bone and soft-tissue sarcoma,central nervous system tumors,leukemia,adrenocortical carcinoma,and breast cancer.This syndrome is associated with the P53 gene in 80% of families that fulfill the clinical criteria.Exome sequencing analysis of the P53 gene was performed on a Japanese family with LFS that includes a 2.5-year-old boy with rhabdomyosarcoma, his mother with osteosarcoma and lung cancer at 11 and 37 years old, respectively, and his maternal grandfather with …
NAID 120006871389

Characterization of a novel nicotinamide adenine dinucleotide-cytochrome b5 reductase mutation associated with canine hereditary methemoglobinemia

OTSUKA-YAMASAKI Yayoi,INANAMI Osamu,SHINO Haruka,SATO Reeko,YAMASAKI Masahiro
Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ, 2020
… Recently, nonsynonymous b5R gene (<i>CYB5R3</i>) variants have been reported to be associated with canine and feline hereditary methemoglobinemia. … We conclude from these results that unstable mutant enzyme properties with normal enzymatic activity would be associated with hereditary methemoglobinemia in the Pomeranian dog family.</p> …
NAID 130007958646