WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
capable of or tending to change in form or quality or nature; "a mutable substance"; "the mutable ways of fortune"; "mutable weather patterns"; "a mutable foreign policy" (同)changeable
informal term for information; "give me the gen on your new line of computers"

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Solar-UV-signature mutation prefers TCG to CCG: extrapolative consideration from UVA1-induced mutation spectra in mouse skin.

Ikehata H, Kumagai J, Ono T, Morita A.SourceDepartment of Cell Biology, Tohoku University Graduate School of Medicine, Sendai, Japan. ikehata@med.tohoku.ac.jp.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.Photochem Photobiol Sci.2013 Jul 30;12(8):1319-27. doi: 10.1039/c3pp25444e.
UVA1 exerts its genotoxicity on mammalian skin by producing cyclobutane pyrimidine dimers (CPDs) in DNA and preferentially inducing solar-UV-signature mutations, C → T base substitution mutations at methylated CpG-associated dipyrimidine (Py-mCpG) sites, as demonstrated previously using a 364 nm l
PMID 23471200

Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations.

Toh ST, Jin Y, Liu L, Wang J, Babrzadeh F, Gharizadeh B, Ronaghi M, Toh HC, Chow PK, Chung AY, Ooi LL, Lee CG.SourceDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Carcinogenesis.Carcinogenesis.2013 Apr;34(4):787-98. doi: 10.1093/carcin/bgs406. Epub 2012 Dec 30.
Chronic hepatitis B virus (HBV) infection is epidemiologically associated with hepatocellular carcinoma (HCC), but its role in HCC remains poorly understood due to technological limitations. In this study, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC pa
PMID 23276797

Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man.

Wright BE, Schmidt KH, Minnick MF.SourceDivision of Biological Sciences, The University of Montana, Missoula, MT 59812, United States. Electronic address: barbara.wright@mso.umt.edu.
Mutation research.Mutat Res.2013 Apr-Jun;752(2):129-37. doi: 10.1016/j.mrrev.2012.12.003. Epub 2012 Dec 26.
This review summarizes the evidence indicating that mutagenic mechanisms in vivo are essentially the same in all living cells. Unique metabolic reactions to a particular environmental stress apparently target specific genes for increased rates of transcription and mutation, resulting in higher mutat
PMID 23274173

Epigenetic silencing and unstable inheritance of MuDR activity monitored at four bz2-mu alleles in maize (Zea mays L.)

TAKUMI Shigeo,WALBOT Virginia
Genes & genetic systems 82(5), 387-401, 2007-10-25
… Maize MuDR/Mu elements are one of the most active Class II transposons and are widely used for transposon tagging for gene cloning. … Four independent Mu-induced mutable alleles of the anthocyanin pigment pathway Bronze2 (Bz2) locus have been sequenced; …
NAID 10024394970