尿細管機能
WordNet
- perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
- (mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
- a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
- the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
- what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
- a formal or official social gathering or ceremony; "it was a black-tie function"
- constituting a tube; having hollow tubes (as for the passage of fluids) (同)cannular, tubelike, tube-shaped, vasiform
- performing or able to perform its regular function; "a functioning flashlight"
PrepTutorEJDIC
- (人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》
- 管状の,管から成る
UpToDate Contents
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English Journal
- Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.
- Yamamoto Y1, Yoshida A1, Miyazaki N2, Iwasaki K2, Sakisaka T1.Author information 1*Division of Membrane Dynamics, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.2†Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, Suita 565-0871, Japan.AbstractThe ER (endoplasmic reticulum) consists of the nuclear envelope and a peripheral network of membrane sheets and tubules. Two classes of the evolutionarily conserved ER membrane proteins, reticulons and REEPs (receptor expression-enhancing proteins)/DP1 (deleted in polyposis locus 1)/Yop1 (YIP 1 partner), shape high-curvature ER tubules. In mammals, four members of the reticulon family and six members of the REEP family have been identified so far. In the present paper we report that Arl6IP1(ADP-ribosylation factor-like 6 interacting protein 1), an anti-apoptotic protein specific to multicellular organisms, is a potential player in shaping the ER tubules in mammalian cells. Arl6IP1, which does not share an overall primary sequence homology with reticulons, harbours reticulon-like short hairpin transmembrane domains and binds to atlastin, a GTPase that mediates the formation of the tubular ER network. Overexpression of Arl6IP1 induced extensive tubular structures of the ER and excluded a luminal protein. Furthermore, overexpression of Arl6IP1 stabilized the ER tubules, allowing the cells to maintain the ER tubules even in the absence of microtubules. Arl6IP1 constricted liposomes into tubules. The short hairpin structures of the transmembrane domains were required for the membrane-shaping activity of Arl6IP1. The results of the present study indicate that Arl6IP1 has the ability to shape high-curvature ER tubules in a reticulon-like fashion.
- The Biochemical journal.Biochem J.2014 Feb 15;458(1):69-79. doi: 10.1042/BJ20131186.
- The ER (endoplasmic reticulum) consists of the nuclear envelope and a peripheral network of membrane sheets and tubules. Two classes of the evolutionarily conserved ER membrane proteins, reticulons and REEPs (receptor expression-enhancing proteins)/DP1 (deleted in polyposis locus 1)/Yop1 (YIP 1 part
- PMID 24262037
- Markers of and risk factors for the development and progression of diabetic kidney disease.
- Macisaac RJ1, Ekinci EI2, Jerums G3.Author information 1Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, Victoria, Australia; University of Melbourne, Victoria, Australia. Electronic address: r.macisaac@unimelb.edu.au.2University of Melbourne, Victoria, Australia; Endocrine Centre & Department of Medicine, Austin Health, Darwin, Australia; Menzies School of Health Research, Darwin, Australia.3University of Melbourne, Victoria, Australia; Endocrine Centre & Department of Medicine, Austin Health, Darwin, Australia.AbstractDiabetic kidney disease (DKD) occurs in 25%-40% of patients with diabetes. Given the dual problems of a significant risk of progression from DKD to end-stage renal disease (ESRD) and increased cardiovascular morbidity and mortality, it is important to identify patients at risk of DKD and ESRD and initiate protective renal and cardiovascular therapies. The importance of preventive therapy is emphasized further by worldwide increases in the incidence of diabetes. This review summarizes the evidence regarding the prognostic value and benefits of targeting established and novel risk markers for DKD development and progression. Family history of DKD, smoking history, and glycemic, blood pressure, and plasma lipid level control are established factors for identifying people at greatest risk of DKD development and progression. Absolute albumin excretion rate (AER) and glomerular filtration rate (GFR) measurements also are important, although AER categorization generally lacks the necessary specificity and sensitivity, and estimates of declining GFR are compromised by methodological limitations for GFRs in the normal-to-high range. Emerging risk markers for progressive loss of kidney function include markers of oxidation and inflammation, profibrotic cytokines, uric acid, advanced glycation end products, functional and structural markers of vascular dysfunction, kidney structural changes, and tubular biomarkers. Among these, the most promising are serum uric acid and soluble tumor necrosis factor receptor (type 1 and type 2) levels, especially in relation to GFR changes. At present, these can only be considered as risk markers because they only identify an individual at increased risk of progressive DKD and not necessarily related to the causal pathway promoting kidney damage. Further work is needed to establish whether modulating these factors improves the prognosis in DKD. Although change in urinary peptidome levels also is a promising marker, there currently is neither a clinical assay nor adequate studies defining its prognostic value. Until these or other novel markers become available for clinical use, predictive accuracy often may be increased with greater attention to established markers.
- American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2014 Feb;63(2 Suppl 2):S39-62. doi: 10.1053/j.ajkd.2013.10.048.
- Diabetic kidney disease (DKD) occurs in 25%-40% of patients with diabetes. Given the dual problems of a significant risk of progression from DKD to end-stage renal disease (ESRD) and increased cardiovascular morbidity and mortality, it is important to identify patients at risk of DKD and ESRD and in
- PMID 24461729
- Histopathologic and Clinical Predictors of Kidney Outcomes in ANCA-Associated Vasculitis.
- Ford SL1, Polkinghorne KR2, Longano A3, Dowling J3, Dayan S3, Kerr PG4, Holdsworth SR1, Kitching AR1, Summers SA5.Author information 1Center for Inflammatory Diseases, Department of Medicine, Monash Medical Center, Clayton, VIC, Australia; Department of Nephrology, Monash Medical Center, Clayton, VIC, Australia; Southern Clinical School, Monash Medical Center, Clayton, VIC, Australia.2Department of Nephrology, Monash Medical Center, Clayton, VIC, Australia; Southern Clinical School, Monash Medical Center, Clayton, VIC, Australia; Department of Epidemiology and Preventative Medicine, Monash University, Prahran, VIC, Australia.3Department of Anatomical Pathology, Monash Medical Center, Clayton, VIC, Australia.4Department of Nephrology, Monash Medical Center, Clayton, VIC, Australia; Southern Clinical School, Monash Medical Center, Clayton, VIC, Australia.5Center for Inflammatory Diseases, Department of Medicine, Monash Medical Center, Clayton, VIC, Australia; Department of Nephrology, Monash Medical Center, Clayton, VIC, Australia; Southern Clinical School, Monash Medical Center, Clayton, VIC, Australia. Electronic address: sharon.ford@monash.edu.AbstractBACKGROUND: A predictive histologic classification recently was proposed to determine the prognostic value of kidney biopsy in patients with antineutrophil cytoplasmic antibody-associated renal vasculitis (AAV).
- American journal of kidney diseases : the official journal of the National Kidney Foundation.Am J Kidney Dis.2014 Feb;63(2):227-35. doi: 10.1053/j.ajkd.2013.08.025. Epub 2013 Oct 30.
- BACKGROUND: A predictive histologic classification recently was proposed to determine the prognostic value of kidney biopsy in patients with antineutrophil cytoplasmic antibody-associated renal vasculitis (AAV).STUDY DESIGN: A dual-purpose retrospective observational cohort study to assess the repro
- PMID 24183110
Japanese Journal
- Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells
- A Case of Quetiapine-related Acute Kidney Injury Requiring Transient Continuous Hemodiafiltration
- Evidence for the hook supercoiling mechanism of the bacterial flagellum
Related Links
- This filtrate then flows along the length of the nephron, which is a tubular structure lined by a single layer of specialized cells and surrounded by capillaries . The major functions of these lining cells are the reabsorption of water and small ...
★リンクテーブル★
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- 英
- tubular function
- 関
- 尿細管
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- survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）
- Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)
- 関
- functional、functional group、functionalise、functionalize、operate
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- 関
- canalicular、kidney tubule、renal tubular、renal tubule、tracheary、tubule、uriniferous tubule