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Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function.

Amiri S1, Amini-Khoei H1, Haj-Mirzaian A1, Rahimi-Balaei M2, Naserzadeh P3, Dehpour A1, Mehr SE4, Hosseini MJ5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep 11. pii: S0304-4165(15)00241-X. doi: 10.1016/j.bbagen.2015.09.009. [Epub ahead of print]
BACKGROUND: Early social isolation stress (SIS) is associated with the occurrence of anxiety behaviors. It seems interaction between the nitrergic system and mitochondrial function plays a role in mediating the anxiety-like behaviors. In this study, we aimed to investigate the anxiolytic effects of
PMID 26367080

Spinal 5-HT3 receptor mediates nociceptive effect on central neuropathic pain; possible therapeutic role for tropisetron.

Nasirinezhad F, Hosseini M, Karami Z, Yousefifard M, Janzadeh A.
The journal of spinal cord medicine.J Spinal Cord Med.2015 Sep 4. [Epub ahead of print]
Objectives To test the analgesic effect of 5-HT-3 receptor antagonist, tropisetron, in a clip compression injury model of spinal cord pain in rats. Methods Four weeks post compression of the spinal cord at lumbar level, tropisetron was administered intrathecally at 100 μg and 150 μg dosages. Beh
PMID 26338446

Beyond the 5-HT3 receptors: A role for α7nACh receptors in neuroprotective aspects of tropisetron.

Khalifeh S1, Fakhfouri G2, Mehr SE3, Mousavizadeh K4, Dehpour AR3, Khodagholi F5, Kazmi S6, Rahimian R7.
Human & experimental toxicology.Hum Exp Toxicol.2015 Sep;34(9):922-31. doi: 10.1177/0960327114562034.
Accumulation of reactive oxygen species, such as hydrogen peroxide (H2O2), generated by inflammatory cells or other pathological conditions, leads to oxidative stress, which may contribute to the neuronal degeneration observed in a wide variety of neurodegenerative disorders such as Alzheimer's dise
PMID 26286524

熊谷章子,酒向淳,大塚友乃,村岡渡,内山公男
歯科薬物療法 19(2), 51-61, 2000-08-01
… Tropisetron hydrochrolide, an oral anti-emetic reported to be as effective as parenteral anti-emetics, was launched Japan in 1998. …
NAID 10016241306