WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/01 19:24:31」(JST)

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Triprolidine (Actidil, Myidil, Actifed[In combination with pseudoephedrine, and either dextromethorphan or guaifenesin] in addition in liquids) is an antihistamine thats often sold over-the-counter that has anticholinergic properties.^[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.^[2] Like many antihistamines, the most common side effect is drowsiness.^[1] Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes.^{[citation needed]}

References

^ ^a ^b Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics 11 (1): 87–95. PMID 8094649. edit
^ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy 3 (6): 638–643. PMID 6509877. edit

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1. アレルギー性鼻炎の薬物療法 pharmacotherapy of allergic rhinitis

English Journal

Histaminergic H1 and H2 Receptors Mediate the Effects of Propofol on the Noradrenalin-Inhibited Neurons in Rat Ventrolateral Preoptic Nucleus.

Liu Y1, Zhang Y2, Qian K1, Zhang L2, Yu T3,4.
Neurochemical research.Neurochem Res.2017 May;42(5):1387-1393. doi: 10.1007/s11064-017-2187-y. Epub 2017 Feb 9.
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Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.

Parmentier R1, Zhao Y2, Perier M1, Akaoka H1, Lintunen M3, Hou Y4, Panula P3, Watanabe T5, Franco P1, Lin JS6.
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PMID 26723880

A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

Rainville PD1, Simeone JL, Root DS, Mallet CR, Wilson ID, Plumb RS.
The Analyst.Analyst.2015 Mar 21;140(6):1921-31. doi: 10.1039/c4an02090a.
PMID 25655051

Japanese Journal

New Plastic Membrane and Carbon Paste Ion Selective Electrodes for the Determination of Triprolidine

ZAYED S. I. M.
Analytical Sciences 20(7), 1043-1048, 2004
… Triprolidine (Trip) ion selective electrodes of three types: the conventional polymer membrane (I), graphite coated electrode (II) and carbon paste electrode (III), have been prepared, based on the ion pair of triprolidine hydrochloride with sodium tetraphenylborate. …
NAID 130004440980

（±）‐１‐（３，４，５‐トリメトキシベンジル）‐６‐ヒドロキシ‐１，２，３，４‐テトラヒドロイソキノリン塩酸（ＣＶ‐７０５）の麻酔犬における血管拡張作用

池沢一郎 [他],長尾拓,佐藤匡徳,中島宏通,清本昭夫
日本薬理学雑誌 73(7), 735-742, 1977
… 麻酔犬における(±)-1-(3, 4, 5-trimethoxybenzyl)-6-hydroxy-1, 2, 3, 4-tetrahydroiso-quinline hydrochloride(CV-705)の血管拡張作用を電磁流量計を用いて調べた．CV-705の静脈内投与による血流量増加作用は，椎骨動脈，総頸動脈ならびに内頸動脈で最も強く，次いで，大腿動脈，大動脈および冠血管の順で，上腸間膜動脈および門脈での作用は極めて弱かった．また，腎血流量は，動脈内投与で軽度に増加したが，静脈内投与でわずかに減少した …
NAID 130000758833

プロエントラの慢性蕁麻疹にたいする効果:—2重盲検·クロスオーバーによる検討—

宮本正光 [他],石橋康正,滝沢清宏,斉田俊明
西日本皮膚科 36(2), 219-223, 1974
NAID 130004830348

Related Pictures

★リンクテーブル★

リンク元	「トリプロリジン」
関連記事	「triprolidine」「hydrochloride」

「トリプロリジン」

Triprolidine
Systematic (IUPAC) name
	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-; prop-1-enyl]pyridine
Clinical data
AHFS/Drugs.com	monograph
Pregnancy; category	C (US);
Legal status	OTC (US);
Routes of; administration	Oral
Pharmacokinetic data
Bioavailability	4% oral
Protein binding	90%
Metabolism	Hepatic (CYP2D6)
Half-life	4-6 hours
Excretion	Renal
Identifiers
CAS Registry Number	486-12-4
ATC code	R06AX07
PubChem	CID 5282443
IUPHAR ligand	1228
DrugBank	DB00427
ChemSpider	4445597
UNII	2L8T9S52QM
KEGG	D01782
ChEBI	CHEBI:84116
ChEMBL	CHEMBL855
Chemical data
Formula	C19H22N2
Molecular mass	278.391 g/mol
	SMILES n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3;
	InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ ; Key:CBEQULMOCCWAQT-WOJGMQOQSA-N ;
Physical data
Melting point	60 °C (140 °F)
Solubility in water	500 mg/mL (20 °C)
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