関: triprolidine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/30 11:47:57」(JST)

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Triprolidine (Actidil, Myidil, Actifed[In combination with pseudoephedrine, and either dextromethorphan or guaifenesin] in addition in liquids) is an over-the-counter antihistamine with anticholinergic properties.^[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.^[2] Like many antihistamines, the most common side effect is drowsiness.^[1] Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes.^{[citation needed]}

References

^ ^a ^b Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics 11 (1): 87–95. PMID 8094649. edit
^ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy 3 (6): 638–643. PMID 6509877. edit

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1. アレルギー性鼻炎の薬物療法 pharmacotherapy of allergic rhinitis

English Journal

A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

Rainville PD1, Simeone JL, Root DS, Mallet CR, Wilson ID, Plumb RS.
The Analyst.Analyst.2015 Mar 21;140(6):1921-31. doi: 10.1039/c4an02090a.
The emergence of micro sampling techniques holds great potential to improve pharmacokinetic data quality, reduce animal usage, and save costs in safety assessment studies. The analysis of these samples presents new challenges for bioanalytical scientists, both in terms of sample processing and analy
PMID 25655051

Effect of premedications in a murine model of asparaginase hypersensitivity.

Fernandez CA1, Smith C1, Karol SE1, Ramsey LB1, Liu C1, Pui CH1, Jeha S1, Evans WE1, Finkelman FD1, Relling MV2.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Mar;352(3):541-51. doi: 10.1124/jpet.114.220780. Epub 2015 Jan 8.
A murine model was developed that recapitulates key features of clinical hypersensitivity to Escherichia coli asparaginase. Sensitized mice developed high levels of anti-asparaginase IgG antibodies and had immediate hypersensitivity reactions to asparaginase upon challenge. Sensitized mice had compl
PMID 25573198

Effects of antihistamines on the function of human α7-nicotinic acetylcholine receptors.

Sadek B1, Khanian SS1, Ashoor A1, Prytkova T2, Ghattas MA3, Atatreh N3, Nurulain SM1, Yang KH2, Howarth FC4, Oz M5.
European journal of pharmacology.Eur J Pharmacol.2015 Jan 5;746:308-16. doi: 10.1016/j.ejphar.2014.10.046. Epub 2014 Nov 8.
Effects of the histamine H₁ receptor (H1R) antagonists (antihistamines), promethazine (PMZ), orphenadrine (ORP), chlorpheniramine (CLP), pyrilamine (PYR), diphenhydramine (DPH), citerizine (CTZ), and triprolidine (TRP) on the functional properties of the cloned α7 subunit of the human nicotinic a
PMID 25445036

Japanese Journal

Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry

SHAKYA Ashok K.,ARAFAT Tawfiq A.,ABUAWWAD Ahmad N.,MELHIM Munther,AL-GHANI Jafar,YACOUB Mahmoud J.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(32), 4071-4078, 2009-12-15
NAID 10028029879

New Plastic Membrane and Carbon Paste Ion Selective Electrodes for the Determination of Triprolidine

Zayed S. I. M.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20(7), 1043-1048, 2004-07-10
NAID 10013285707

New Plastic Membrane and Carbon Paste Ion Selective Electrodes for the Determination of Triprolidine

ZAYED S. I. M.
Analytical Sciences 20(7), 1043-1048, 2004
… Triprolidine (Trip) ion selective electrodes of three types: the conventional polymer membrane (I), graphite coated electrode (II) and carbon paste electrode (III), have been prepared, based on the ion pair of triprolidine hydrochloride with sodium tetraphenylborate. …
NAID 130004440980

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リンク元	「トリプロリジン」
拡張検索	「triprolidine hydrochloride」

「トリプロリジン」

Triprolidine
Systematic (IUPAC) name
	2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-; prop-1-enyl]pyridine
Clinical data
AHFS/Drugs.com	monograph
Pregnancy cat.	C (US)
Legal status	OTC (US)
Routes	Oral
Pharmacokinetic data
Bioavailability	4% oral
Protein binding	90%
Metabolism	Hepatic (CYP2D6)
Half-life	4-6 hours
Excretion	Renal
Identifiers
CAS number	486-12-4
ATC code	R06AX07
PubChem	CID 5282443
IUPHAR ligand	1228
DrugBank	DB00427
ChemSpider	4445597
UNII	2L8T9S52QM
KEGG	D01782
ChEMBL	CHEMBL855
Chemical data
Formula	C19H22N2
Mol. mass	278.391 g/mol
	SMILES n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3;
	InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ ; Key:CBEQULMOCCWAQT-WOJGMQOQSA-N ;
Physical data
Melt. point	60 °C (140 °F)
Solubility in water	500 mg/mL (20 °C)
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