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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/15 19:41:19」(JST)

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Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.

Fetal trimethadione syndrome

If administered during pregnancy, fetal trimethadione syndrome may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects, intrauterine growth restriction (IUGR), and mental retardation. The fetal loss rate while using trimethadione has been reported to be as high as 87%.^[1]

References

^ Teratology and Drug Use During Pregnancy Retrieved January 2007

External links

MedlinePlus DrugInfo medmaster-a601127
DDB 30479

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English Journal

Noninvasive high-resolution ultrasound reveals structural and functional deficits in dimethadione-exposed fetal rat hearts in utero.

Purssell E, Weston AD, Thomson JJ, Swanson TA, Brown NA, Ozolinš TR.SourceDepartment of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada.
Birth defects research. Part B, Developmental and reproductive toxicology.Birth Defects Res B Dev Reprod Toxicol.2011 Nov 29. doi: 10.1002/bdrb.20339. [Epub ahead of print]
BACKGROUND: We previously showed dimethadione (DMO), the N-demethylated metabolite of the anticonvulsant trimethadione, induces ventricular septation defects (VSD) and other heart anomalies in rat (Weston et al., 2011). Because of the relationship between cardiac structure and function, we hypothesi
PMID 22127902

Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.

Weston AD, Brown NA, Ozolinš TR.SourceDepartment of Developmental and Reprodutive Toxicology, Pfizer Global Research and Development, Groton, Connecticut, USA.
Birth defects research. Part B, Developmental and reproductive toxicology.Birth Defects Res B Dev Reprod Toxicol.2011 Jun;92(3):206-15. doi: 10.1002/bdrb.20302. Epub 2011 Jun 2.
BACKGROUND: The anticonvulsant trimethadione is a potent inducer of ventricular septation defects, both clinically and in rodents. Teratogenicity requires its N-demethylation to dimethadione, the proximate teratogen. It was previously demonstrated trimethadione only induced membranous ventricular se
PMID 21638752

Japanese Journal

<原著>石灰化膵石症および蛋白栓や粘稠膵液に対する経口膵石溶解療法の効果

山本真紀子,野田愛司,伊吹恵里,泉順子,太田美樹子,大竹円
愛知医科大学医学会雑誌 30(4), 209-221, 2002-12-15
… In the present study, trimethadione was given orally as a precursor of dimethadione to 37 patients with calcific pancreatitis. … The 37 patients not treated with trimethadione were selected as a control. … In conclusion, we believe that the OLT by trimethadione or bromhexine-hydro-chloride becomes a useful tool for chemical dissolution of calcific pancreatic stones or for recurrent pain relief by eliminating protein plugs and viscous pancreatic juice. …
NAID 110000042321

Embryonic Arrhythmia by Inhibition of HERG Channels: A Common Hypoxia-related Teratogenic Mechanism for Antiepileptic Drugs?

AZARBAYJANI Faranak,DANIELSSON Bengt R.
Epilepsia : journal of the International League against Epilepsy 43(5), 457-468, 2002-05-01
NAID 10010875436

Effect of the Macrolide Antibiotic Clarithromycin on the Metabolism of Trimethadione and Antipyrine: Strain Difference in SD and Wistar Rats

KITASHIRO Reiji,KURATA Norimitsu,NISHIMURA Yuki,UCHIDA Eiji,YASUHARA Hajime
The Showa University Journal of Medical Sciences 11(1), 7-15, 1999
… Effects of both antibiotics on hepatic microsomal drugmetabolizing enzymes were estimated by antipyrine pharmacokinetics and the formation rates of 3-hydroxymethyl antipyrine (HMA), 4-hydroxyantipyrine (OHA) and norantipyrine (NORA), and by the serum ratio of dimethadione to trimethadione (DMO/TMO) . …
NAID 130004189968

Related Pictures

★リンクテーブル★

リンク元	「トリメタジオン」「TMO」

「トリメタジオン」

Trimethadione
Systematic (IUPAC) name
	3,5,5-trimethyl-1,3-oxazolidine-2,4-dione
Clinical data
Trade names	Tridione
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	X;
Routes of; administration	Oral
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	High
Metabolism	Demethylated to dimethadione
Biological half-life	12–24 hours (trimethadione); 6–13 days (dimethadione)
Excretion	Renal
Identifiers
CAS Number	127-48-0
ATC code	N03AC02 (WHO)
PubChem	CID 5576
IUPHAR/BPS	7316
DrugBank	DB00347
ChemSpider	5374
UNII	R7GV3H6FQ4
KEGG	D00392
ChEMBL	CHEMBL695
Chemical data
Formula	C6H9NO3
Molar mass	143.141 g/mol
	SMILES O=C1N(C(=O)OC1(C)C)C ;
	InChI InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3 ; Key:IRYJRGCIQBGHIV-UHFFFAOYSA-N ;
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