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1. Cystic fibrosis: Carrier screening
2. 小児および思春期における慢性膵炎の原因 causes of chronic pancreatitis in children and adolescents
3. 嚢胞性線維症：臨床症状および診断 cystic fibrosis clinical manifestations and diagnosis
4. 成人における慢性膵炎の病因および発症機序 etiology and pathogenesis of chronic pancreatitis in adults
5. 原発性硬化性胆管炎：疫学および病因 primary sclerosing cholangitis epidemiology and pathogenesis

English Journal

μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.

Convertino M1, Samoshkin A2, Gauthier J3, Gold MS4, Maixner W5, Dokholyan NV6, Diatchenko L7.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2015 Oct 1;62:61-7. doi: 10.1016/j.pnpbp.2014.11.009. Epub 2014 Dec 6.
The μ-opioid receptor (MOR) is the primary target for opioid analgesics. MOR induces analgesia through the inhibition of second messenger pathways and the modulation of ion channels activity. Nevertheless, cellular excitation has also been demonstrated, and proposed to mediate reduction of therapeu
PMID 25485963

Nicotinic acetylcholine receptor-lipid interactions: Mechanistic insight and biological function.

Baenziger JE1, Hénault CM2, Therien JP2, Sun J2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1848(9):1806-17. doi: 10.1016/j.bbamem.2015.03.010. Epub 2015 Mar 16.
Membrane lipids are potent modulators of the nicotinic acetylcholine receptor (nAChR) from Torpedo. Lipids influence nAChR function by both conformational selection and kinetic mechanisms, stabilizing varying proportions of activatable versus non-activatable conformations, as well as influencing the
PMID 25791350

Functional competition within a membrane: Lipid recognition vs. transmembrane helix oligomerization.

Stangl M1, Schneider D2.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Sep;1848(9):1886-96. doi: 10.1016/j.bbamem.2015.03.011. Epub 2015 Mar 16.
Binding of specific lipids to large, polytopic membrane proteins is well described, and it is clear that such lipids are crucial for protein stability and activity. In contrast, binding of defined lipid species to individual transmembrane helices and regulation of transmembrane helix monomer-oligome
PMID 25791349

Hemolytic Lectin CEL-III Heptamerizes via a Large Structural Transition from α-Helices to a β-Barrel during the Transmembrane Pore Formation Process

Unno Hideaki,Goda Shuichiro,Hatakeyama Tomomitsu
Journal of Biological Chemistry 289(18), 12805-12812, 2014-05-02
… After binding to the cell surface carbohydrate chains through domains 1 and 2, domain 3 self-associates to form transmembrane pores, leading to cell lysis or death, which resembles other pore-forming toxins of diverse organisms. … The CEL-III oligomer has a heptameric structure with a long β-barrel as a transmembrane pore. …
NAID 120005438987

1P037 Roles of two coupling helices between transmembrane and cytosolic domains in ABC transporter(01B. Protein:Structure & Function,Poster)

Roles of conserved Arg⁷² and Tyr⁷¹ in the ascorbate-specific transmembrane electron transfer catalyzed by Zea mays cytochrome b₅₆₁

Rahman Motiur Md.,Nakanishi Nobuyuki,Sakamoto Yoichi [他],Hori Hiroshi,Hase Toshiharu,Park Sam-Yong,Tsubaki Motonari
Journal of bioscience and bioengineering 115(5), 497-506, 2013-05
… Cytochromes b_<561>, novel transmembrane electron transport proteins residing in eukaryotic cells, have a number of common features including six transmembrane α-helices and two heme ligation sites. …
NAID 110009611452