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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/03/02 21:40:46」(JST)
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Tonofibrils are cytoplasmic protein structures in epithelial tissues[1] that converge at desmosomes and hemidesmosomes.
Tonofilaments are also associated with desmosomes (macula adherens), anchoring them to the cytoskeleton.
Composition
They are made of keratin (a type of intermediate filament in the cytoskeleton) tonofilaments.[2] Tonofilaments are keratin intermediate filaments that make up tonofibrils in epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes.
The protein filaggrin is believed to have an important role in holding them together as tonofibrils.
References
- ^ "tonofibril" at Dorland's Medical Dictionary
- ^ Yoon KH, Yoon M, Moir RD, Khuon S, Flitney FW, Goldman RD (April 2001). "Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells". J. Cell Biol. 153 (3): 503–16. doi:10.1083/jcb.153.3.503. PMC 2190576. PMID 11331302.
External links
Protein: scleroproteins
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Extracellular matrix |
Collagen |
Fibril forming |
- type I
- type II (COL2A1)
- type III
- type V
- COL24A1
- COL26A1
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Other |
- FACIT: type IX
- type XII (COL12A1)
- COL14A1
- COL16A1
- COL19A1
- COL20A1
- COL21A1
- COL22A1
- basement membrane: type IV
- COL4A1
- COL4A2
- COL4A3
- COL4A4
- COL4A5
- COL4A6
- multiplexin: COL15A1
- type XVIII
- transmembrane: COL13A1
- COL17A1
- COL23A1
- COL25A1
- other: type VI
- COL6A1
- COL6A2
- COL6A3
- COL6A5
- type VII (COL7A1)
- type VIII
- type X (COL10A1)
- type XI
- COL27A1
- COL28A1
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Enzymes |
- Prolyl hydroxylase/Lysyl hydroxylase
- Cartilage associated protein/Leprecan
- ADAMTS2
- Procollagen peptidase
- Lysyl oxidase
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Laminin |
- alpha
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- beta
- gamma
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Other |
- ALCAM
- Elastin
- Vitronectin
- FRAS1
- FREM2
- Decorin
- FAM20C
- ECM1
- Matrix gla protein
- Tectorin
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Other |
- Keratin/Cytokeratin
- Gelatin
- Reticulin
- Cartilage oligomeric matrix protein
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Description |
- Proteins
- Membrane,
- Globular
- antibodies
- Fibrous
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Proteins of the cytoskeleton
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Human |
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Nonhuman |
- Major sperm proteins
- Prokaryotic cytoskeleton
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See also: cytoskeletal defects
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Description |
- strc
- edmb
- skel
- epit
- cili
- mito
- Nucleus
- Template:Chromosome genetics
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Histology: Epithelial proteins (TH H1.00.01.1)
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Lateral/cell-cell |
- Cell adhesion molecules: Adherens junction
- Desmosome
- Ion channels: Gap junction/Connexon
- Cytoskeleton: Desmosome
- Desmoplakin
- Plakoglobin
- Tonofibril
- other membrane proteins: Tight junction
- Claudin
- Occludin
- MARVELD2
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Basal/cell-matrix |
- Basal lamina
- Hemidesmosome/Tonofibril
- Focal adhesion
- Costamere
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Apical |
- Cilia/Kinocilium
- Microvilli/Stereocilia (STRC)
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Description |
- strc
- edmb
- skel
- epit
- cili
- mito
- Nucleus
- Template:Chromosome genetics
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English Journal
- Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner.
- McInroy L, Maatta A.AbstractCo-ordination of cytoskeletal networks and their dynamics is an essential feature of cell migration and cancer cell invasion. Plectin is a large cytolinker protein that influences tissue integrity, organisation of actin and intermediate filaments, and cell migration. Alternatively spliced plectin isoforms are targeted to different subcellular locations. Here, we show that plectin ablation by siRNA impaired migration, invasion and adhesion of SW480 colon carcinoma cells. A previously less well characterised plectin isoform, plectin-1k, co-localised with epithelial integrins, N-WASP, cortactin, and dynamin in podosome-like adhesions in invasive SW480 colon carcinoma cells. Transfection of alternative plectin N-terminal constructs demonstrated that the first exons of isoforms 1k, 1 and 1d can target the actin-binding domain of plectin to podosome-like adhesions. Finally, Plectin-1k N-terminus rescued adhesion site formation in plectin knock-down cells. Thus, plectin participates in actin assembly and invasiveness in carcinoma cells in an isoform-specific manner.
- Experimental cell research.Exp Cell Res.2011 Oct 15;317(17):2468-78. Epub 2011 Jul 29.
- Co-ordination of cytoskeletal networks and their dynamics is an essential feature of cell migration and cancer cell invasion. Plectin is a large cytolinker protein that influences tissue integrity, organisation of actin and intermediate filaments, and cell migration. Alternatively spliced plectin is
- PMID 21821021
Japanese Journal
- Oral Candidiasis: A Histopathological, Ultrastructural and Immunohistochemical Study
- International Journal of Oral-Medical Sciences 12(3), 171-182, 2014
- … Ultrastructually, Candidal hyphe internalized into the epithelial cytoplasmic vacuole resembling endocytosis.Destruction of desmosomal cell junction and deficit of tonofilament was also observed at the tip of the hypha. …
- NAID 130003395899
- Astroblastoma : Immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
- KUBOTA Toshihiko,SATO Kazufumi,ARISHIMA Hidetaka,TAKEUCHI Hiroaki,KITAI Ryuhei,NAKAGAWA Takao
- Neuropathology : official journal the Japanese Society of Neuropathology 26(1), 72-81, 2006-02-01
- … The fine structure revealed divergent types of junctional complexes, some of which were connected with tonofilament bundles. …
- NAID 10020387417
- D-バリン培地法により選択的に初代培養したラット胆管上皮細胞に対する Phospholipase A_2 の細胞増殖促進効果の解析
- 小倉 薫,渡辺 泰宏,平峯 千春,中川 利孝,土岐 彰,徳田 雅明
- 岡山醫學會雜誌 114(3), 289-296, 2003-01-31
- … They were stained with anti-cytokeratin antibody, a marker protein of epithelial cells, were positive with PAS stain, and possessed the architectures of microvilli, tonofilament fibers and desmosomes. …
- NAID 10012337225
Related Links
- 世界大百科事典 第2版 - tonofilamentの用語解説 - 中間繊維の網目状構造は,まず核を取り囲む籠状の構造を形づくり,一方では,細胞膜上の付着点に発し,離れた細胞膜上の付着点に至るかすがい状に走る網目状の構造を形づくっている。
- ton·o·fil·a·ment (ton'ō-fil'ă-ment), A structural cytoplasmic protein, of a class known as intermediate filaments, bundles of which together form a tonofibril; a tonofilament is made up of a variable number of related proteins, keratins, and ...
Related Pictures
★リンクテーブル★
[★]
- 英
- intermediate filament
- 同
- 中間径線維、10nmフィラメント、中間径繊維
- 関
- 細胞
- tonofilament
[★]
- 英
- tonofilament
- 関
- 中間径フィラメント